Short Lives with Long-Lasting Effects: Filopodia Protrusions in Neuronal Branching Morphogenesis

The branching behaviors of both dendrites and axons are part of a neuronal maturation process initiated by the generation of small and transient membrane protrusions. These are highly dynamic, actin-enriched structures, collectively called filopodia, which can mature in neurons to form stable branches. Consequently, the generation of filopodia protrusions is crucial during the formation of neuronal circuits and involves the precise control of an interplay between the plasma membrane and actin dynamics. In this issue of PLOS Biology, Hou and colleagues identify a Ca2+/CaM-dependent molecular machinery in dendrites that ensures proper targeting of branch formation by activation of the actin nucleator Cobl.

• Publication year

  2015

• Venue

  PLoS Biology

• Publication date

  2015-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1371/journal.pbio.1002241PMID 26334727PMCID 4559444
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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