Humoral immunity in the central nervous system of Lewis rats infected with Borna disease virus.

The aim of this study was to investigate the humoral immune response to Borna disease (BD) virus in the brain of experimentally infected Lewis rats. Abundant IgG was detected in BD-rat brain with isotype variation throughout infection. IgG was locally produced as indicated by an intact blood-brain barrier, Ig kappa light chain mRNA-containing cells in brain and accumulation of virus-specific antibodies in cerebrospinal fluid. Treatment with BD-rat serum altered viral gene expression in persistently infected cultured rat glioblastoma cells. These data suggest that antibodies, produced in the brain, may influence viral gene expression.

• Publication year

  1998

• Venue

  Journal of Neuroimmunology

• Publication date

  1998-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0165-5728(98)00066-6PMID 9817440
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The cerebrospinal fluid of rabbits infected with Borna disease virus

  2005cited by this paper
• Determination of immune cells and expression of major histocompatibility complex class II antigen in encephalitic lesions of experimental Borna disease

  2004cited by this paper
• Evolution of the immune response in the central nervous system following infection with Borna disease virus.

  1998cited by this paper
• Immunology Taught by Viruses

  1996cited by this paper
• Expression of C1q, a subcomponent of the rat complement system, is dramatically enhanced in brains of rats with either Borna disease or experimental allergic encephalomyelitis.

  1995cited by this paper
• Neutralizing antibodies in Borna disease virus-infected rats

  1995cited by this paper
• The atypical strategies used for gene expression of Borna disease virus, a nonsegmented, negative-strand RNA virus.

  1995cited by this paper
• Enzyme-linked immunosorbent assay for detecting antibodies to Borna disease virus-specific proteins

  1995cited by this paper
• RNA splicing in Borna disease virus, a nonsegmented, negative-strand RNA virus

  1994cited by this paper
• Quantitative analysis of immunoglobulin G subclasses in the rat.

  1993cited by this paper
• Antibody-mediated clearance of viruses from the mammalian central nervous system

  1993cited by this paper
• Characterization of a glial cell line persistently infected with borna disease virus (BDV): influence of neurotrophic factors on BDV protein and RNA expression

  1993cited by this paper
• Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system.

  1992cited by this paper
• Antibody-dependent transcriptional regulation of measles virus in persistently infected neural cells

  1992cited by this paper
• Changes in physiological parameters of rat cerebrospinal fluid during chronic sampling: evaluation of two sampling methods.

  1991cited by this paper
• Antibody-mediated clearance of alphavirus infection from neurons.

  1991cited by this paper
• Isolation and characterization of Borna disease agent cDNA clones.

  1990cited by this paper
• Antibody-induced restriction of viral gene expression in measles encephalitis in rats

  1990cited by this paper
• Borna disease: a persistent virus infection of the central nervous system.

  1988cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation

  1987cited by this paper
• Murine hepatitis virus-4 (strain JHM)-induced neurologic disease is modulated in Vivo by monoclonal antibody

  1984cited by this paper
• Pathogenesis of Borna disease in rats: immune-mediated viral ophthalmoencephalopathy causing blindness and behavioral abnormalities.

  1983cited by this paper
• Identification and quantitation of T lymphocyte subsets found in the spinal cord of the Lewis rat during acute experimental allergic encephalomyelitis.

  1983cited by this paper
• Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

  1979cited by this paper
• [Comparative studies on the demonstration and formation of serum antibodies against the Borna virus].

  1978cited by this paper
• Demonstration of specific antibodies in the central nervous system of horses naturally infected with Borna disease virus

  1977cited by this paper
• Maturation of the head of bacteriophage T4. III. DNA packaging into preformed heads.

  1974cited by this paper
• Maturation of the head of bacteriophage T4. I. DNA packaging events.

  1973cited by this paper
• Maturation of the head of bacteriophage T4. II. Head-related, aberrant tau-particles.

  1973cited by this paper

• Nature’s defense against emerging neurodegenerative threats: Dynamic simulation, PCA, DCCM identified potential plant-based antiviral lead targeting borna disease virus nucleoprotein

  2024cites this paper
• 18 Cellular Immunotherapy for Malignant Brain Tumors

  2018cites this paper
• Plasma protein, haematologic and blood chemistry changes in African grey parrots (Psittacus erithacus) experimentally infected with bornavirus

  2017cites this paper
• Chapter 22 – Borna Disease

  2014cites this paper
• Characterizing the expression profile of angiogenic proteins after acute spinal cord injury

  2012cites this paper
• Effects of human immunodeficiency virus encephalitis and drug abuse on the B lymphocyte population of the brain

  2011influential citation
• Vascular Disruption and the Role of Angiogenic Proteins After Spinal Cord Injury

  2011cites this paper
• Cellular Immunotherapy for Malignant Brain Tumors

  2011cites this paper
• Borna Disease Virus

  2010cites this paper
• HIV-1 subtype B determinants of neuropathogenesis: viral characteristics associated with dementia

  2010cites this paper
• The nervous system as ectopic germinal center: CXCL13 and IgG in lyme neuroborreliosis

  2005cites this paper
• Long-Term Presence of Virus-Specific Plasma Cells in Sensory Ganglia and Spinal Cord following Intravaginal Inoculation of Herpes Simplex Virus Type 2

  2005cites this paper
• Long-Term Presence of Virus-Specific Plasma Cells in Sensory Ganglia and Spinal Cord following Intravaginal Inoculation of Herpes Simplex Virus Type 2 cytokines secreted by local inflammatory cells

  2005cites this paper
• Inhibition of Borna Disease Virus-Mediated Cell Fusion by Monoclonal Antibodies Directed against the Viral Glycoprotein

  2004cites this paper
• and by a Novel Orf Virus Recombinant Borna Disease Virus Infection of the Brain Protection against Immunopathology after Prevention of Virus Persistence and

  2004cites this paper
• Microarray- und immungenetische Untersuchungen bei Schizophrenie

  2004cites this paper
• Prevention of Virus Persistence and Protection against Immunopathology after Borna Disease Virus Infection of the Brain by a Novel Orf Virus Recombinant

  2003cites this paper
• Immune responses to RNA-virus infections of the CNS

  2003cites this paper
• Immune-mediated clearance of virus from the central nervous system.

  2003cites this paper
• The immunopathogenesis of Borna disease virus infection.

  2002cites this paper
• Experimental Infection: Pathogenesis of Neurobehavioral Disease

  2002cites this paper
• Humoral immune response against Borna disease virus (BDV) in experimentally and naturally infected cats.

  2002cites this paper
• Borna disease virus infection of adult and neonatal rats: models for neuropsychiatric disease.

  2001cites this paper
• Bornavirus tropism and targeted pathogenesis: virus-host interactions in a neurodevelopmental model.

  2001cites this paper
• Borna disease virus

  2001cites this paper
• High-Dose Borna Disease Virus Infection Induces a Nucleoprotein-Specific Cytotoxic T-Lymphocyte Response and Prevention of Immunopathology

  2001influential citation
• Neutralizing Antibodies in Persistent Borna Disease Virus Infection: Prophylactic Effect of gp94-Specific Monoclonal Antibodies in Preventing Encephalitis

  2001cites this paper
• Planz Preventing Encephalitis of gp 94-Specific Monoclonal Antibodies in Disease Virus Infection : Prophylactic Effect Neutralizing Antibodies in Persistent Borna

  2000cites this paper
• Bornavirus immunopathogenesis in rodents: models for human neurological diseases.

  1999cites this paper
• Immunobiology of the blood-brain barrier.

  1999cites this paper