Modeling therapy resistance via the EGFR signaling pathway

Mutations in KRAS are often associated with resistance to EGFR‐targeting antibody therapy. Using comprehensive systems analyses, GNB5 has been identified as a potential target to overcome therapy resistance targeting the EGFR signaling pathways, whereby the AKT signaling pathway (PI3K) rather than the ERK signaling pathway (RAS) might be dominantly affected. Personalized mathematical modeling and simulations of this signaling pathway/network and respective perturbations are of great utility to customize therapy for patients.

• Publication year

  2019

• Venue

  The FEBS Journal

• Publication date

  2019-03-20

• Fields of study

  Biology, Medicine, Mathematics

• Identifiers
  DOI 10.1111/febs.14809PMID 30892828PMCID 6850018
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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