Induction of Hepatitis C Virus E1 Envelope Protein-Specific Immune Response Can Be Enhanced by Mutation of N-Glycosylation Sites

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Virology

• Publication date

  2001-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.75.24.12088-12097.2001PMID 11711599PMCID PMC116104
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Epidemiology of hepatitis C].

  2002cited by this paper
• Immunobiology of hepatitis C virus (HCV) infection: the role of CD4 T cells in HCV infection

  2000cited by this paper
• Strategies and prospects for vaccination against the hepatitis C viruses.

  2000cited by this paper
• CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained

  2000cited by this paper
• Antibodies Against Hepatitis C Virus–Like Particles and Viral Clearance in Acute and Chronic Hepatitis C

  2000cited by this paper
• Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

  2000cited by this paper
• Glycosylation of the Hepatitis C Virus Envelope Protein E1 Is Dependent on the Presence of a Downstream Sequence on the Viral Polyprotein*

  2000cited by this paper
• Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C

  2000cited by this paper
• Hepatitis C virus-like particles synthesized in insect cells as a potential vaccine candidate.

  1999cited by this paper
• Analysis of a successful immune response against hepatitis C virus.

  1999cited by this paper
• Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C.

  1999cited by this paper
• T(h)1 but not T(h)0 cell help is efficient to induce cytotoxic T lymphocytes by immunization with short synthetic peptides.

  1999cited by this paper
• Limited humoral immunity in hepatitis C virus infection.

  1999cited by this paper
• DNA immunization: effect of secretion of DNA-expressed hemagglutinins on antibody responses.

  1999cited by this paper
• Analysis of the glycosylation sites of hepatitis C virus (HCV) glycoprotein E1 and the influence of E1 glycans on the formation of the HCV glycoprotein complex.

  1999cited by this paper
• Pathogenesis of chronic hepatitis C: Immunological features of hepatic injury and viral persistence

  1999cited by this paper
• Recurrence of hepatitis C virus after loss of virus specific CD4+ T cell response in acute hepatitis C

  1998cited by this paper
• Hepatitis C Virus Structural Proteins Assemble into Viruslike Particles in Insect Cells

  1998cited by this paper
• A role for carbohydrates in immune evasion in AIDS

  1998cited by this paper
• Intrahepatic hepatitis C virus–specific cytotoxic T lymphocyte activity and response to interferon alfa therapy in chronic hepatitis C

  1998cited by this paper
• Lectins as chaperones in glycoprotein folding.

  1998cited by this paper
• Plasmid DNA Expressing a Secreted or a Nonsecreted Form of Hepatitis C Virus Nucleocapsid: Comparative Studies of Antibody and T-Helper Responses Following Genetic Immunization

  1997cited by this paper
• Characterization of truncated forms of hepatitis C virus glycoproteins.

  1997cited by this paper
• Introduction of a Glycosylation Site into a Secreted Protein Provides Evidence for an Alternative Antigen Processing Pathway: Transport of Precursors of Major Histocompatability Complex Class I–Restricted Peptides from the Endoplasmic Reticulum to the Cytosol

  1997cited by this paper
• Induction of cytotoxic T‐cell response against hepatitis C virus structural antigens using a defective recombinant adenovirus

  1997cited by this paper
• Epitope mapping of antibodies directed against hypervariable region 1 in acute self-limiting and chronic infections due to hepatitis C virus

  1997cited by this paper
• Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection

  1997cited by this paper
• Detection of type 2‐like T‐helper cells in hepatitis C virus infection: Implications for hepatitis C virus chronicity

  1997cited by this paper
• Cytotoxic T lymphocyte response and viral load in hepatitis C virus infection

  1997cited by this paper
• Processing of the E1 glycoprotein of hepatitis C virus expressed in mammalian cells.

  1996cited by this paper
• Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response.

  1996cited by this paper
• A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells.

  1996cited by this paper
• N-linked glycans in the CD4-binding domain of human immunodeficiency virus type 1 envelope glycoprotein gp160 are essential for the in vivo priming of T cells recognizing an epitope located in their vicinity.

  1996cited by this paper
• A hyperimmune serum against a synthetic peptide corresponding to the hypervariable region 1 of hepatitis C virus can prevent viral infection in cell cultures.

  1996cited by this paper
• Epidemiology of hepatitis C.

  1996cited by this paper
• Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response.

  1996cited by this paper
• Antibodies in human sera specific to hypervariable region 1 of hepatitis C virus can block viral attachment.

  1995cited by this paper
• Induction of HIV‐1 envelope (gp120)‐specific cytotoxic T lymphocyte responses in mice by recombinant CHO cell‐derived gp120 is enhanced by enzymatic removal of N‐linked glycans

  1994cited by this paper
• The complement- but not mannose receptor-mediated phagocytosis is involved in the hepatic uptake of cetylmannoside-modified liposomes in situ.

  1994cited by this paper
• Processing of E1 and E2 glycoproteins of hepatitis C virus expressed in mammalian and insect cells.

  1994cited by this paper
• Complex processing and protein:protein interactions in the E2:NS2 region of HCV.

  1994cited by this paper
• Formation and intracellular localization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia and Sindbis viruses

  1994cited by this paper
• Characterization and mapping of a B-cell immunogenic domain in hepatitis C virus E2 glycoprotein using a yeast peptide library.

  1994cited by this paper
• An N-glycan within the human immunodeficiency virus type 1 gp120 V3 loop affects virus neutralization.

  1994cited by this paper
• Specificity of antibodies produced against native or desialylated human immunodeficiency virus type 1 recombinant gp160

  1993cited by this paper
• Concepts and principles of glycobiology

  1993cited by this paper
• Hepatitis C virus-specific CTL responses in the liver of chimpanzees with acute and chronic hepatitis C.

  1993cited by this paper
• Immunity in hepatitis C infection.

  1992cited by this paper
• Effects of mutations in glycosylation sites and disulphide bonds on processing, CD4-binding and fusion activity of human immunodeficiency virus envelope glycoproteins.

  1991cited by this paper
• Absence of asparagine-linked oligosaccharides from glycoprotein D of herpes simplex virus type 1 results in a structurally altered but biologically active protein

  1991cited by this paper
• New mammalian expression vectors

  1990cited by this paper
• Product review. New mammalian expression vectors.

  1990cited by this paper
• Glycobiology.

  1988cited by this paper
• Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.

  1986cited by this paper
• Expression of rabies virus glycoprotein from a recombinant vaccinia virus

  1984cited by this paper
• Epidemiology of hepatitis.

  1965cited by this paper

• Comparative Efficacy of Mayaro Virus-Like Particle Vaccines Produced in Insect or Mammalian Cells

  2023cites this paper
• Egg-Derived Anti-SARS-CoV-2 Immunoglobulin Y (IgY) With Broad Variant Activity as Intranasal Prophylaxis Against COVID-19

  2022cites this paper
• Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies

  2021cites this paper
• Enterovirus A71 Vaccines

  2021cites this paper
• Evaluation of Japanese encephalitis virus E and NS1 proteins immunogenicity using a recombinant Newcastle disease virus in mice.

  2020cites this paper
• Hepatitis C virus vaccine design: focus on the humoral immune response

  2020cites this paper
• Impact of Protein Glycosylation on the Design of Viral Vaccines.

  2020cites this paper
• Evaluation of surface glycoproteins of classical swine fever virus as immunogens and reagents for serological diagnosis of infections in pigs: a recombinant Newcastle disease virus approach

  2019cites this paper
• A Hepatitis C Virus DNA Vaccine Encoding a Secreted, Oligomerized Form of Envelope Proteins Is Highly Immunogenic and Elicits Neutralizing Antibodies in Vaccinated Mice

  2019cites this paper
• Function of the HCV E1 envelope glycoprotein in viral entry and assembly

  2019cites this paper
• Influenza Hemagglutinin Structures and Antibody Recognition.

  2019cites this paper
• Current Progress and Challenges in the Development of a Hepatitis C Virus Vaccine

  2019cites this paper
• Structural and Epitope Analysis (T- and B-Cell Epitopes) of Hepatitis C Virus (HCV) Glycoproteins: An in silico Approach.

  2018cites this paper
• Role of Hepatitis C Virus Envelope Glycoprotein E1 in Virus Entry and Assembly

  2018cites this paper
• Glycan Shielding and Modulation of Hepatitis C Virus Neutralizing Antibodies

  2018cites this paper
• Structural and [27_TD$DIFF] Epitope Analysis (T- and B-Cell Epitopes) of Hepatitis C Virus (HCV) [28_TD$DIFF] Glycoproteins: An in silico Approach

  2018cites this paper
• Global aspects of viral glycosylation

  2018influential citation
• Viral glycoproteomes: technologies for characterization and outlook for vaccine design

  2018cites this paper
• Role of Endoplasmic Reticulum Stress in Hepatic Injury

  2017cites this paper
• Identification of human IgG1 variant with enhanced FcRn binding and without increased binding to rheumatoid factor autoantibody

  2017cites this paper
• In silico structure analysis and epitope prediction of E3 CR1-beta protein of Human Adenovirus E for vaccine design

  2016cites this paper
• N-glycosylation-mutated HCV envelope glycoprotein complex enhances antigen-presenting activity and cellular and neutralizing antibody responses.

  2016cites this paper
• Global Mapping of O-Glycosylation of Varicella Zoster Virus, Human Cytomegalovirus, and Epstein-Barr Virus*

  2016cites this paper
• Developing antibody discovery and recombination technology towards the goal of modulating cation channels

  2016cites this paper
• Structure–function analysis of hepatitis C virus envelope glycoproteins E1 and E2

  2015influential citation
• HBsAg sT123N mutation induces stronger antibody responses to HBsAg and HBcAg and accelerates in vivo HBsAg clearance.

  2015cites this paper
• Characterization of HCV Genotype 5a Envelope Proteins: Implications for Vaccine Development and Therapeutic Entry Target

  2014cites this paper
• Characterization of the enterovirus 71 P1 polyprotein expressed in Pichia pastor as a candidate vaccine

  2014cites this paper
• Fine Mapping of Murine Antibody Responses to Immunization with a Novel Soluble Form of Hepatitis C Virus Envelope Glycoprotein Complex

  2014cites this paper
• Experimental design of a novel target to isolate HCV monoclonal antibodies

  2014cites this paper
• Structural characterization of viral envelope glycoproteins

  2014cites this paper
• Identification of the determinants of efficient Pestivirus replication

  2013cites this paper
• HCV Envelope protein 2 sequence comparison of Pakistani isolate and In-silico prediction of conserved epitopes for vaccine development

  2013cites this paper
• Use of baculovirus expression system for generation of virus-like particles: Successes and challenges

  2013cites this paper
• Structural analysis and epitope prediction of HCV E1 protein isolated in Pakistan: an in-silico approach

  2013cites this paper
• Characterization Of Hcv Genotype 3a Structural Proteins Core, E1, E2 And Development Of Pseudotype Particles (HCVCC) And Intergenotypic Chimera (HCVCC)

  2013cites this paper
• Etude des facteurs viraux et cellulaires impliqués dans l'échappement du virus de l'hépatite C au cours de la transplantation hépatique

  2013cites this paper
• Development of techniques for the isolation and characterisation of human monoclonal antibodies from Hepatitis C virus infected individuals

  2012cites this paper
• Universal peptide vaccines - optimal peptide vaccine design based on viral sequence conservation.

  2011cites this paper
• Effects of glycosylation on antigenicity and immunogenicity of classical swine fever virus envelope proteins.

  2011influential citation
• Glycosylation of minor envelope glycoproteins of porcine reproductive and respiratory syndrome virus in infectious virus recovery, receptor interaction, and immune response.

  2011cites this paper
• The Hepatitis C Virus Glycan Shield and Evasion of the Humoral Immune Response

  2011cites this paper
• The glycoproteins of porcine reproductive and respiratory syndrome virus and their role in infection and immunity

  2010cites this paper
• A reinvestigation provides no evidence for sugar residues on structural proteins of poleroviruses and argues against a role for glycosylation of virus structural proteins in aphid transmission.

  2010cites this paper
• ER Stress Signaling in Hepatic Injury

  2010cites this paper
• The malarial drug target Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR): development of a 3-D model for identification of novel, structural and functional features and for inhibitor screening.

  2010cites this paper
• Influenza A virus in Taiwan, 1980–2006: Phylogenetic and antigenic characteristics of the hemagglutinin gene

  2009cites this paper
• Full-Length Characterization of Hepatitis C Virus Subtype 3a Reveals Novel Hypervariable Regions under Positive Selection during Acute Infection

  2009cites this paper
• 1 Host Neutralizing Responses and Pathogenesis of Hepatitis C Virus Infection

  2009cites this paper
• The role of positive selection in hepatitis C virus.

  2009cites this paper
• Anticorps neutralisants dirigés contre le virus de l’hépatite C

  2008cites this paper
• Impact of glycosylation on antigenicity of simian immunodeficiency virus SIV239: induction of rapid V1/V2-specific non-neutralizing antibody and delayed neutralizing antibody following infection with an attenuated deglycosylated mutant.

  2008cites this paper
• Dissection of endoplasmic reticulum stress signaling in alcoholic and non‐alcoholic liver injury

  2008cites this paper
• [Neutralizing antibodies in hepatitis C virus infection].

  2008cites this paper
• Hepatitis C virus envelope glycoprotein co-evolutionary dynamics during chronic hepatitis C.

  2008cites this paper
• Host neutralizing responses and pathogenesis of hepatitis C virus infection

  2008cites this paper
• Hepatitis C virus entry and neutralization.

  2008cites this paper
• Cross-genotype characterization of genetic diversity and molecular adaptation in hepatitis C virus envelope glycoprotein genes.

  2007cites this paper
• Neutralizing antibodies in hepatitis C virus infection.

  2007cites this paper
• Evolutionary study of hepatitis C virus envelope genes during primary infection.

  2007cites this paper
• The Neutralizing Activity of Anti-Hepatitis C Virus Antibodies Is Modulated by Specific Glycans on the E2 Envelope Protein

  2007cites this paper
• Monosaccharides modulate HCV E2 protein-derived peptide biological properties.

  2007cites this paper
• Engineering of N-glycosylation of hepatitis C virus envelope protein E2 enhances T cell responses for DNA immunization.

  2007cites this paper
• The bioinformatics analysis of hepatitis C virus E2 protein

  2007cites this paper
• Development of a heterologous, multigenotype vaccine against hepatitis C virus infection

  2007cites this paper
• Host Neutralizing Responses in Hepatitis C Virus Infection

  2007cites this paper
• Deletion of N-glycosylation sites of hepatitis C virus envelope protein E1 enhances specific cellular and humoral immune responses.

  2007cites this paper
• Factors that influence VSV‐G pseudotyping and transduction efficiency of lentiviral vectors—in vitro and in vivo implications

  2007cites this paper
• Roles of glycans and glycopeptides in immune system and immune-related diseases.

  2006cites this paper
• Using maximum likelihood method to detect adaptive evolution of HCV envelope protein-coding genes

  2006cites this paper
• Comparison of Antibody- and Cell-Mediated Immune Responses After Intramuscular Hepatitis C Immunizations of BALB/c Mice

  2005cites this paper
• Molecular Epidemiology of Hepatitis C Virus Genotype 4 Isolates in Egypt and Analysis of the Variability of Envelope Proteins E1 and E2 in Patients with Chronic Hepatitis

  2005cites this paper
• Purification and application of C-terminally truncated hepatitis C virus E1 proteins expressed in Escherichia coli.

  2005cites this paper
• Evolutionary dynamics of hepatitis C virus envelope genes during chronic infection.

  2005cites this paper
• Influence of N-linked glycans on intracellular transport of hepatitis C virus E1 chimeric glycoprotein and its role in pseudotype virus infectivity.

  2004cites this paper
• Tracking global patterns of N-linked glycosylation site variation in highly variable viral glycoproteins: HIV, SIV, and HCV envelopes and influenza hemagglutinin.

  2004cites this paper
• Hepatitis vaccines.

  2004cites this paper
• HCV E2 glycoprotein: mutagenesis of N-linked glycosylation sites and its effects on E2 expression and processing.

  2004cites this paper
• High-Resolution Phylogenetic Analysis of Hepatitis C Virus Adaptation and Its Relationship to Disease Progression

  2004cites this paper
• Comparative immunogenicity analysis of modified vaccinia Ankara vectors expressing native or modified forms of hepatitis C virus E1 and E2 glycoproteins.

  2004cites this paper
• Development of a hepatitis C virus vaccine.

  2003cites this paper
• Comparative Vaccine Studies in HLA-A2.1-Transgenic Mice Reveal a Clustered Organization of Epitopes Presented in Hepatitis C Virus Natural Infection

  2002cites this paper
• Variant analysis and immunogenicity prediction of envelope gene of HCV strains from China

  2002cites this paper
• The challenge of developing a vaccine against hepatitis C virus.

  2002cites this paper
• Hepatitis C Virus Envelope Glycoproteins and Potential for Vaccine Development

  2002cites this paper
• PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version

  2001cites this paper