The Potential Roles of Actin in The Nucleus

Over the past few decades, actin’s presence in the nucleus has been demonstrated. Actin is a key protein necessary for different nuclear processes. Although actin is well known for its functional role in dynamic behavior of the cytoskeleton, emerging studies are now highlighting new roles for actin. At the present time there is no doubt about the presence of actin in the nucleus. A number of studies have uncovered the functional involvement of actin in nuclear processes. Actin as one of the nuclear components has its own structured and functional rules, such as nuclear matrix association, chromatin remodeling, transcription by RNA polymerases I, II, III and mRNA processing. In this historical review, we attempt to provide an overview of our current understanding of the functions of actin in the nucleus.

• Publication year

  2015

• Venue

  Cell journal

• Publication date

  2015-04-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.22074/CELLJ.2015.507PMID 25870830PMCID 4393673
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Active maintenance of nuclear actin by importin 9 supports transcription

  2012cited by this paper
• Nuclear functions of actin.

  2010cited by this paper
• Actin complexes in the cell nucleus: new stones in an old field

  2010cited by this paper
• Nuclear actin and actin‐binding proteins in the regulation of transcription and gene expression

  2009cited by this paper
• Cell and molecular biology of nuclear actin.

  2009influential reference
• AN OVERVIEW TO THE STRUCTURE AND FUNCTION OF NUCLEAR MATRIX

  2009cited by this paper
• Nuclear actin dynamics – From form to function

  2008cited by this paper
• Chromatin remodelling and actin organisation

  2008cited by this paper
• Nuclear actin in plants

  2008cited by this paper
• The HSA domain binds nuclear actin-related proteins to regulate chromatin-remodeling ATPases

  2008cited by this paper
• The regulation of ATP-dependent nucleosome remodelling factors.

  2007cited by this paper
• Regulation of actin filament assembly by Arp2/3 complex and formins.

  2007cited by this paper
• Crossing the Nuclear Envelope: Hierarchical Regulation of Nucleocytoplasmic Transport

  2007cited by this paper
• Identification of nonhistone protein LMG(160) as a ribonucleoprotein of the nuclear matrix with a role in transcription in vitro.

  2007cited by this paper
• Mechanisms of ATP dependent chromatin remodeling.

  2007cited by this paper
• The function of actin in gene transcription.

  2007cited by this paper
• Nuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL

  2007cited by this paper
• Nuclear actin and actin-related proteins in chromatin dynamics.

  2007cited by this paper
• Actin and myosin as transcription factors.

  2006cited by this paper
• Molecular functions of nuclear actin in transcription

  2006cited by this paper
• Actin in transcription and transcription regulation.

  2006influential reference
• Nucleoplasmic β-actin exists in a dynamic equilibrium between low-mobility polymeric species and rapidly diffusing populations

  2006cited by this paper
• A selective block of nuclear actin export stabilizes the giant nuclei of Xenopus oocytes

  2006influential reference
• Exporting actin

  2006cited by this paper
• The growing pre-mRNA recruits actin and chromatin-modifying factors to transcriptionally active genes.

  2005cited by this paper
• Conformation-specific antibodies reveal distinct actin structures in the nucleus and the cytoplasm.

  2005cited by this paper
• A simple model for the cooperative stabilisation of actin filaments by phalloidin and jasplakinolide

  2005cited by this paper
• Nuclear distribution of actin and myosin I depends on transcriptional activity of the cell

  2005cited by this paper
• An actin-myosin complex on actively transcribing genes.

  2004cited by this paper
• Actin- and protein-4.1-containing filaments link nuclear pore complexes to subnuclear organelles in Xenopus oocyte nuclei

  2004cited by this paper
• Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II

  2004cited by this paper
• Nuclear actin and myosin I are required for RNA polymerase I transcription

  2004cited by this paper
• A role for beta-actin in RNA polymerase III transcription.

  2004cited by this paper
• Increased importin-β-dependent nuclear import of the actin modulating protein CapG promotes cell invasion

  2004cited by this paper
• Latrunculin B or ATP Depletion Induces Cofilin-dependent Translocation of Actin into Nuclei of Mast Cells* 210

  2003cited by this paper
• Exportin 6: a novel nuclear export receptor that is specific for profilin·actin complexes

  2003influential reference
• Messenger-RNA-binding proteins and the messages they carry

  2002cited by this paper
• Regulating the mammalian genome: the role of nuclear architecture.

  2002cited by this paper
• Genomics, the cytoskeleton and motility

  2001cited by this paper
• The p400 complex is an essential E1A transformation target.

  2001cited by this paper
• Recovery of gel-separated proteins for in-solution digestion and mass spectrometry.

  2001cited by this paper
• Actin Bound to the Heterogeneous Nuclear Ribonucleoprotein Hrp36 Is Associated with Balbiani Ring mRNA from the Gene to Polysomes

  2001cited by this paper
• Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis.

  2000cited by this paper
• Cytochemical Evidence for the Presence of Actin in the Nucleus of the Voodoo Lily Appendix

  2000cited by this paper
• A chromatin remodelling complex involved in transcription and DNA processing

  2000cited by this paper
• A new look at the nuclear matrix

  2000cited by this paper
• Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription.

  2000cited by this paper
• Peripheral nuclear matrix actin forms perinuclear shells

  1998cited by this paper
• Nuclear export of actin: a novel mechanism regulating the subcellular localization of a major cytoskeletal protein

  1998cited by this paper
• Immunofluorescent localization of actin in relation to transcription sites in mouse pronuclei

  1998cited by this paper
• Crystal structure of the nucleosome core particle at 2.8 Å resolution

  1997cited by this paper
• Connecting nuclear architecture and genomic function

  1996cited by this paper
• Nuclear and cytoplasmic actin in dinoflagellates.

  1996cited by this paper
• Nuclear actin filaments and their topological changes in frog oocytes.

  1995cited by this paper
• An actin infrastructure is associated with eukaryotic chromosomes: structural and functional significance.

  1994cited by this paper
• hnRNP proteins and the biogenesis of mRNA.

  1993cited by this paper
• Distribution of snRNPs, splicing factor SC-35 and actin in interphase nuclei: immunocytochemical evidence for differential distribution during changes in functional states.

  1993cited by this paper
• The KKRKK sequence is involved in heat shock-induced nuclear translocation of the 18-kDa actin-binding protein, cofilin.

  1992cited by this paper
• Autographa californica MNPV nucleocapsid assembly: inhibition by cytochalasin D.

  1988cited by this paper
• Does the interchromatin compartment contain actin?

  1987cited by this paper
• Is actin a transcription initiation factor for RNA polymerase B?

  1984cited by this paper
• Microinjection of actin-binding proteins and actin antibodies demonstrates involvement of nuclear actin in transcription of lampbrush chromosomes.

  1984cited by this paper
• In vivo identification of Tetrahymena actin probed by DMSO induction nuclear bundles.

  1982cited by this paper
• Involvement of contractile proteins in the changes in consistency of oocyte nucleoplasm of the newt Pleurodeles waltlii

  1981cited by this paper
• Characterization of pre-messenger-RNA-containing nuclear ribonucleoprotein particles from avian erythroblasts.

  1979cited by this paper
• Two-dimensional analysis of proteins associated with heterogenous nuclear RNA in various animal cell lines.

  1979cited by this paper
• Actin co-purifies with RNA polymerase II.

  1979cited by this paper
• At least six different actins are expressed in a higher mammal: an analysis based on the amino acid sequence of the amino-terminal tryptic peptide.

  1978cited by this paper
• Diffusible and bound actin nuclei of Xenopus laevis oocytes.

  1977cited by this paper
• Isolation and characterization of chromatin from the cellular slime mold, Dictyostelium discoideum.

  1977cited by this paper
• Comparative protein patterns in chromatins from mouse teratocarcinoma cells.

  1976cited by this paper
• The germinal vesicle nucleus of Xenopus laevis oocytes as a selective storage receptacle for proteins

  1976cited by this paper
• Identification of a nuclear protein matrix.

  1974cited by this paper
• Synthesis and Some Properties of an Actin-Like Nuclear Protein in the Slime Mold Physarum polycephalum

  1971cited by this paper
• [EXTRACTION OF A PROTEIN RESEMBLING ACTIN FROM THE CELL NUCLEUS OF THE CALF THYMUS].

  1963cited by this paper
• Extraktion eines dem Aktin ähnlichen Proteins aus dem Zellkern des Kalbsthymus

  1963cited by this paper
• SMALL GRANULES IN THE AMPHIBIAN OOCYTE NUCLEUS AND THEIR RELATIONSHIP TO RNA

  1956cited by this paper

• RNA Polymerase II Activity and Nuclear Actin: Possible Roles of Nuclear Tropomyosin, Troponin and Ca2+ in Transcription in Striated Muscle Myocyte Nuclei

  2025cites this paper
• Partial Progesterone Deprivation Affects the Expression of Apoptosis-Specific Genes and Proteins in a Zone-Specific Manner in Rat Placenta

  2025cites this paper
• The Protein Encoded by the UL3.5 Gene of the Duck Plague Virus Affects Viral Secondary Envelopment, Release, and Cell-to-Cell Spread

  2025cites this paper
• Anticancer Effect of PtIIPHENSS, PtII5MESS, PtII56MESS and Their Platinum(IV)-Dihydroxy Derivatives against Triple-Negative Breast Cancer and Cisplatin-Resistant Colorectal Cancer

  2024cites this paper
• Tensile Overload Injures Human Alveolar Epithelial Cells through YAP/F-Actin/MAPK Signaling

  2023cites this paper
• Actin polymerization and depolymerization in developing vertebrates

  2023cites this paper
• Special Nuclear Structures in the Germinal Vesicle of the Common Frog with Emphasis on the So-Called Karyosphere Capsule

  2023cites this paper
• TaACTIN7-D regulates plant height and grain shape in bread wheat.

  2023cites this paper
• Effect of the Rho-Kinase/ROCK Signaling Pathway on Cytoskeleton Components

  2023cites this paper
• Actin's C‐terminus coordinates actin structural changes and functions

  2023cites this paper
• Nuclear fascin regulates cancer cell survival

  2022cites this paper
• Transgelin-2: A Double-Edged Sword in Immunity and Cancer Metastasis

  2021cites this paper
• Identification of Actin Filament Interactors in Giardia lamblia

  2021cites this paper
• Identification of Actin Filament-Associated Proteins in Giardia lamblia

  2021cites this paper
• Time for rethinking the different β‐actin transgenic mouse models?

  2020cites this paper
• Regulation of actin isoforms in cellular and developmental processes.

  2020cites this paper
• Immunomodulator Drug (IMODTM) and Exercise Improve Cardiac Oxidative Stress and Antioxidant Balance in Diabetic Rats

  2020cites this paper
• The effect of low doses of doxorubicin on the rat glioma C6 cells in the context of the proteins involved in intercellular interactions.

  2020cites this paper
• Silicon-incorporated nanohydroxyapatite-reinforced poly(ε-caprolactone) film to enhance osteogenesis for bone tissue engineering applications.

  2019cites this paper
• Understanding molecular mechanisms of disease through spatial proteomics.

  2019cites this paper
• The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells

  2019cites this paper
• Expression and function of exportin 6 in full-grown and growing porcine oocytes

  2019cites this paper
• The Extracellular Matrix Receptor Discoidin Domain Receptor 1 Regulates Collagen Transcription by Translocating to the Nucleus.

  2019cites this paper
• Evaluation of the actin binding natural compounds Miuraenamide A and Chivosazole A

  2019cites this paper
• O-GlcNAcylation and Phosphorylation of β-Actin Serine199 in Diabetic Nephropathy.

  2019cites this paper
• Ebola Virus VP40 Modulates Cell Cycle and Biogenesis of Extracellular Vesicles

  2018cites this paper
• The Impact of Cytokines and HSV-1 on Rab5 Protein Expression, F-actin Cytoskeleton Rearrangement, and Cell Viability of Uninfected and Virus-Infected M0, M1, and M2 RAW264.7 Murine Macrophages

  2018cites this paper
• Nuclear actin: ancient clue to evolution in eukaryotes?

  2018cites this paper
• The actin remodeling protein cofilin is crucial for thymic αβ but not γδ T-cell development

  2018cites this paper
• MiR-206 Target Prediction in Breast Cancer Subtypes by Bioinformatics Tools

  2018cites this paper
• The Stress-Inducible Protein DRR1 Exerts Distinct Effects on Actin Dynamics

  2018cites this paper
• THE IMPACT OF CYTOKINES AND HSV-1 ON RAB5 PROTEIN EXPRESSION, F- ACTIN CYTOSKELETON REARRANGEMENT, AND CELL VIABILITY OF UNINFECTED AND VIRUS-INFECTED M0, M1, AND M2 RAW 264.7 MURINE MACROPHAGES

  2018cites this paper
• Posttranscriptional and Posttranslational Regulation of Actin

  2018cites this paper
• The makings of the ‘actin code': regulation of actin's biological function at the amino acid and nucleotide level

  2018cites this paper
• Transcriptional effects of actin-binding compounds: the cytoplasm sets the tone

  2018cites this paper
• Adducin family proteins possess different nuclear export potentials

  2017cites this paper
• Extracellular actin in health and disease

  2017cites this paper
• Control of nuclear organization by F-actin binding proteins

  2017cites this paper
• Inside the Cell: Integrins as New Governors of Nuclear Alterations?

  2017cites this paper
• Localization of nuclear actin in nuclear lipid microdomains of liver and hepatoma cells: Possible involvement of sphingomyelin metabolism

  2017cites this paper
• Overexpression of lamin B1 induces mitotic catastrophe in colon cancer LoVo cells and is associated with worse clinical outcomes

  2017cites this paper
• Intact Expression of Hypoxia-Inducible Factor 1α (HIF-1α) Gene in HeLa Cell Line Following Treatment with Lactobacilli Supernatants

  2017cites this paper
• Diseases of the Cytoskeleton: The Desminopathies

  2017cites this paper
• Long non-coding RNA GHET1 Is Possibly Involved in the Pathogenesis of a Fraction of Breast Cancers

  2017cites this paper
• Effect of hydrogen peroxide treatment on the proteome profile of Musca domestica larvae / Tan Yong Hao

  2016cites this paper
• The Impact of HSV-1 Infection, SOCS1 peptide, and SOCS3 peptide mimetic on CellViability, Morphology, and Cytoskeleton Proteins of Unpolarized and Cytokine-PolarizedM1 RAW 264.7 Murine Macrophages

  2016cites this paper
• The scope and impact of post-transcriptional gene regulation in plants - microRNAs and the RNA-binding proteome of Arabidopsis

  2016cites this paper
• β-Actin regulates interleukin 6-induced p21 transcription by interacting with the Rpb5 and Rpb7 subunits of RNA polymerase II

  2016cites this paper
• In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings

  2016cites this paper
• Nucleus-associated actin in Amoeba proteus.

  2016cites this paper
• Lactobacilli Differentially Modulate mTOR and Wnt/ β-Catenin Pathways in Different Cancer Cell Lines

  2016cites this paper
• The karyosphere capsule in oocytes of hibernating frogs Rana temporaria contains actin, lamins, and SnRNP

  2016cites this paper
• Actin, actin-binding proteins, and actin-related proteins in the nucleus

  2016cites this paper
• ucleus-associated actin in Amoeba proteus

  2016cites this paper