Prognostic relevance of epidermal growth factor receptor (EGF-R) and c-neu/erbB2 expression in glioblastomas (GBMs)

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Journal of Neuro-Oncology

• Publication date

  1993-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/BF01324695PMID 7507162
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nonparametric Statistics for the Behavioral Sciences

  2022cited by this paper
• Immunohistochemical studies on oncogene products (c-erbB-2, EGFR, c-myc) and estrogen receptor in benign and malignant breast lesions

  2005cited by this paper
• EGF receptor amplification and expression in human brain tumours.

  1992cited by this paper
• Amplification of Epidermal Growth Factor Receptor Gene in Gliomas: Histopathology and Prognosis

  1992cited by this paper
• Radiolabeled antibody targeting of the HER-2/neu oncoprotein.

  1992cited by this paper
• A monoclonal antibody against the c-erbB-2 protein enhances the cytotoxicity of cis-diamminedichloroplatinum against human breast and ovarian tumor cell lines.

  1991cited by this paper
• Expression of Epidermal Growth Factor Receptor (EGF-R) and Erb-B2 (HER 2/NEU) in Glioblastoma (GEM): Prognosttc Relevance

  1991cited by this paper
• Findings of Aberrant Epidermal Growth Factor Receptor in Primary Human Malignant Gliomas

  1991cited by this paper
• Epidermal growth factor receptors in intracranial and breast tumours: their clinical significance.

  1991cited by this paper
• Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo.

  1991cited by this paper
• Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product.

  1990cited by this paper
• Iodine-125-labeled anti-epidermal growth factor receptor-425 in the treatment of glioblastoma multiforme. A pilot study.

  1990cited by this paper
• Cytogenetics and Molecular Genetics of Malignant Gliomas and Medulloblastoma

  1990cited by this paper
• Investigation of the expression of epidermal growth factor receptor and blood group A antigen in 110 human gliomas

  1990influential reference
• High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses

  1990cited by this paper
• Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma.

  1990cited by this paper
• Preparation and characterization of monoclonal antibodies specific for human transforming growth factor alpha.

  1990cited by this paper
• Cancer statistics, 1990

  1990cited by this paper
• Epidermal growth factor receptor in human glioma.

  1989influential reference
• Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer.

  1989cited by this paper
• Immunocytochemical and biochemical analysis of epidermal growth factor receptor expression in human breast cancer tissues: Relationship to estrogen receptor and lymphatic invasion

  1989cited by this paper
• Iodine-125-labeled anti-epidermal growth factor receptor-425 in the treatment of glioblastoma multiforme. A pilot study.

  1989cited by this paper
• Sequential expression and cooperative interaction of c-Ha-ras and c-erbB genes in in vivo chemical carcinogenesis.

  1989cited by this paper
• Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer.

  1989cited by this paper
• Antibody guided diagnosis and therapy of brain gliomas using radiolabeled monoclonal antibodies against epidermal growth factor receptor and placental alkaline phosphatase.

  1989cited by this paper
• Analysis of c-erbB-2 expression in breast carcinomas with clinical follow-up.

  1989cited by this paper
• Amplified gene for the epidermal growth factor receptor in a human glioblastoma cell line encodes an enzymatically inactive protein

  1988cited by this paper
• Localization of immunoreactive epidermal growth factor receptors in human nervous system.

  1988cited by this paper
• Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading.

  1988cited by this paper
• Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts.

  1988cited by this paper
• Interaction between epidermal growth factor and its receptor in progression of human gastric carcinoma

  1988cited by this paper
• Quantitative assays of epidermal growth factor receptor in human breast cancer: Cut‐off points of clinical relevance

  1988cited by this paper
• Occurrence of epidermal growth factor receptors in human adnexal tumors and their prognostic value in advanced ovarian carcinomas.

  1988cited by this paper
• Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer.

  1988influential reference
• Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors

  1988cited by this paper
• Gene Amplification in Malignant Human Gliomas: Clinical and Histopathologic Aspects

  1988influential reference
• The prognostic importance of tumor size in malignant gliomas: a computed tomographic scan study by the Brain Tumor Cooperative Group.

  1988cited by this paper
• Astrocyte mitogen inhibitor related to epidermal growth factor receptor.

  1988cited by this paper
• Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.

  1987cited by this paper
• Epidermal growth factor receptors in non-small cell lung cancer.

  1987cited by this paper
• Evaluation of epidermal growth factor receptors in bladder tumours.

  1987cited by this paper
• Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.

  1987cited by this paper
• Epidermal growth factor receptor expression in human lung carcinomas defined by a monoclonal antibody.

  1987cited by this paper
• Expression of the c‐erbB‐2 protein in normal and transformed cells

  1987cited by this paper
• Prognostic significance of the receptor for epidermal growth factor in human mammary carcinomas.

  1987cited by this paper
• Epidermal growth factor receptors in lung tumours

  1987cited by this paper
• Immunohistochemical localization of the epidermal growth factor receptor in normal human tissues.

  1986cited by this paper
• Expression of epidermal growth factor receptors on normal human gastric epithelia and gastric carcinomas.

  1986cited by this paper
• Role of epidermal growth factor in carcinogenesis.

  1986cited by this paper
• Human epidermal growth factor in gastric carcinoma as a biologic marker of high malignancy.

  1986cited by this paper
• Epidermal-growth-factor receptors in human bladder cancer: comparison of invasive and superficial tumours.

  1985cited by this paper
• Activated proto-onc genes: sufficient or necessary for cancer?

  1985cited by this paper
• Glioblastoma multiforme and anaplastic astrocytoma pathologic criteria and prognostic implications

  1985influential reference
• Amplification and Overexpression of the EGF Receptor Gene in Primary Human Glioblastomas

  1985cited by this paper
• Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

  1984cited by this paper
• Cellular oncogenes and retroviruses.

  1983cited by this paper
• Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma.

  1983cited by this paper
• Treatment of primary brain tumors.

  1979cited by this paper
• Epidemiology of primary nervous system neoplasms.

  1978cited by this paper
• Epidemiology of primary nervous system neoplasms.

  1978cited by this paper
• Letter: Vitamin-C-induced hyperoxaluria.

  1976cited by this paper

• Receptor Tyrosine Kinases: Principles and Functions in Glioma Invasion.

  2020cites this paper
• Eradication of glioblastoma by immuno-virotherapy with a retargeted oncolytic HSV in a preclinical model

  2019cites this paper
• The Unwanted Cell Migration in the Brain: Glioma Metastasis

  2017cites this paper
• Lack of HER2/neu Amplification in Melanoma with both IHC and in Situ Hybridization

  2015cites this paper
• Negative HER2/neu amplification using immunohistochemistry and chromogenic in situ hybridization techniques in skin melanoma cases.

  2015cites this paper
• Lack of prognostic significance of C-erbB-2 expression in low- and high- grade astrocytomas.

  2014influential citation
• Die Rolle des EGFR/HER2-Signalwegs in Gehirnmetastasen des Mammakarzinoms

  2014cites this paper
• Dosimetry in brain tumor phantom at 15 MV 3D conformal radiation therapy

  2013cites this paper
• C-erbB2/HER2 in Human Gliomas, Medulloblastomas, and Meningiomas

  2013cites this paper
• Receptor tyrosine kinases: principles and functions in glioma invasion.

  2013cites this paper
• Efficacy of HER2 retargeted herpes simplex virus as therapy for high-grade glioma in immunocompetent mice

  2012cites this paper
• Replication-competent herpes simplex virus retargeted to HER2 as therapy for high-grade glioma.

  2012cites this paper
• Adoptive Immunotherapy Against Malignant Glioma Using Survivin- specific CTLs Expanded by W6/32 Antibody-mediated Artificial Antigen- presenting Cells

  2011cites this paper
• Use of dentritic cells pulsed with HLA-A2-restricted MAGE-A1 peptide to generate cytotoxic T lymphocytes against malignant glioma

  2010cites this paper
• Long-term outcomes in children with glioblastoma.

  2010cites this paper
• A Role For Lipid Rafts In Egfr Tki Resistance In Breast Cancer

  2010cites this paper
• ErbB receptor signaling in astrocytes: a mediator of neuron-glia communication in the mature central nervous system.

  2010cites this paper
• Human glioma cell culture: two FCS-free media could be recommended for clinical use in immunotherapy

  2009cites this paper
• Isolation and partial characterization of a new human glioblastoma cell line.

  2009cites this paper
• The DNA demethylating agent 5‐aza‐2′‐deoxycytidine activates NY‐ESO‐1 antigenicity in orthotopic human glioma

  2008cites this paper
• Induction of an antigen specific humoral immune response by immunization with the aggregate‐free human TGFα‐P64k fusion protein

  2008cites this paper
• Molekularzytogenetische Charakterisierung von Glioblastomen mit einer oligodendroglialen Komponente als Beitrag zur Einführung einer individuellen Diagnostik

  2008cites this paper
• Long-term survival with glioblastoma multiforme.

  2007cites this paper
• In vitro responsiveness of glioma cell lines to multimodality treatment with radiotherapy, temozolomide, and epidermal growth factor receptor inhibition with cetuximab.

  2007cites this paper
• Prognosis factors of survival time in patients with glioblastoma multiforme: a multivariate analysis of 340 patients

  2007cites this paper
• Higher glioblastoma tumour burden reduces efficacy of chemotherapeutic agents: in vitro evidence.

  2007cites this paper
• Coexpression of c-erbB 1-4 receptor proteins in human glioblastomas. An immunohistochemical study.

  2007cites this paper
• The enlargement of the hormone immune deprivation concept to the blocking of TGFα-autocrine loop: EGFR signaling inhibition

  2006cites this paper
• The enlargement of the hormone immune deprivation concept to the blocking of TGFalpha-autocrine loop: EGFR signaling inhibition.

  2006cites this paper
• Increasing of HER2 Membranar Density in Human Glioblastoma U251MG Cell Line Established in a New Nude Mice Model

  2006cites this paper
• Epidermal growth factor receptor (EGFR) expression in childhood brain tumors.

  2005cites this paper
• Molecular Diagnostics in Central Nervous System Tumors

  2005cites this paper
• Experimental studies in brain tumours : with special regard to multidrug resistance and the ErbB-family

  2005cites this paper
• Experimental studies in brain tumours - with special regard to multidrug resistance and the ErbB - family

  2005cites this paper
• Epidermal growth factor receptor family (EGFR, ErbB2–4) in gliomas and meningiomas

  2004cites this paper
• Immunohistochemical determination of HER-2/neu, c-Kit (CD117), and vascular endothelial growth factor (VEGF) overexpression in malignant melanoma

  2004cites this paper
• The influence of sex and the presence of giant cells on postoperative long-term survival in adult patients with supratentorial glioblastoma multiforme.

  2004cites this paper
• [Radioimmunolocalization of head and neck tumors with a new monoclonal antibody against the EGF receptor. Preliminary results].

  2004cites this paper
• HER-2, gp100, and MAGE-1 Are Expressed in Human Glioblastoma and Recognized by Cytotoxic T Cells

  2004cites this paper
• Recombinant humanised anti-HER2/neu antibody (Herceptin®) induces cellular death of glioblastomas

  2004cites this paper
• Radioinmunolocalización de tumores de cabeza y cuello con un nuevo anticuerpo monoclonal contra el receptor del EGF. Resultados preliminares

  2004cites this paper
• Untersuchungen zum Einsatz von small interfering RNAs gegen epidermal growth factor receptor in humanen Gliomzellen

  2004cites this paper
• Epidermal growth factor receptor amplification does not have prognostic significance in patients with glioblastoma multiforme.

  2004cites this paper
• Targeted therapy for malignant gliomas.

  2004cites this paper
• AIM-2: A Novel Tumor Antigen is Expressed and Presented by Human Glioma Cells

  2004cites this paper
• De novo cerebellar medulloblastoma in a 26-year recurrence-free case of temporal glioblastoma multiforme. Case report.

  2003cites this paper
• Prognostic relevance of MAPK expression in glioblastoma multiforme.

  2003cites this paper
• The role of growth factors in central nervous system tumours.

  2003cites this paper
• MIB-1 and DNA topoisomerase II alpha could be helpful for predicting long-term survival of patients with glioblastoma.

  2003cites this paper
• Immunohistochemical determination of HER-2/neu overexpression in malignant melanoma reveals no prognostic value, while c-Kit (CD117) overexpression exhibits potential therapeutic implications

  2003cites this paper
• Growth Factor Expression in Central Nervous System Tumours

  2003cites this paper
• Immunohistochemical determination of HER-2/neu in malignant melanoma.

  2003cites this paper
• MIB-1 and DNA Topoisomerase IIα Could Be Helpful for Predicting Long-Term Survival of Patients With Glioblastoma

  2003cites this paper
• The significance of immunohistochemistry in the diagnosis and therapy of neoplasms

  2002cites this paper
• Immunohistochemical Markers for Prognosis of Cerebral Glioblastomas

  2002cites this paper
• EGFR overexpression and radiation response in glioblastoma multiforme.

  2001cites this paper
• Perspectives in the treatment of malignant gliomas in adults.

  2001cites this paper
• Cytogenetic and molecular abnormalities in astrocytic gliomas (Review).

  2000cites this paper
• Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells.

  2000cites this paper
• Amplification and overexpression of HER-2/neu are uncommon in advanced stage melanoma.

  2000cites this paper
• Growth Factors in Gliomas Revisited

  2000cites this paper
• Genetic alterations in adult diffuse glioma: occurrence, significance, and prognostic implications.

  2000cites this paper
• Bcl-2 Expression in Higher-grade Human Glioma: A Clinical and Experimental Study

  2000cites this paper
• Radioiodinated antibody targeting of the HER-2/neu oncoprotein: effects of labeling method on cellular processing and tissue distribution.

  1999cites this paper
• Epidermal growth factor receptor expression and gene amplification in high-grade non-brainstem gliomas of childhood.

  1999cites this paper
• Long-Term Survival in Cerebral Glioblastoma. Case Report and Critical Review of the Literature

  1998cites this paper
• Comparative analysis of proliferating cell nuclear antigen and epidermal growth factor receptor expression in glial tumours: correlation with histological grading.

  1998cites this paper
• Protein tyrosine kinases and cancer.

  1997cites this paper
• Inhibition of epidermal growth factor receptor-associated tyrosine kinase blocks glioblastoma invasion of the brain.

  1997cites this paper
• Clinical and prognostic significance of the expression of the c-erbB-2 and c-erbB-3 oncoproteins in primary and metastatic malignant melanomas and breast carcinomas.

  1997cites this paper
• Epidermal growth factor and laminin receptors contribute to migratory and invasive properties of gliomas.

  1997cites this paper
• Monoclonal antibodies to growth factors and growth factor receptors: their diagnostic and therapeutic potential in brain tumors

  1997influential citation
• Prognostic factors in malignant glioma: Influence of the overexpression of oncogene and tumor-suppressor gene products on survival

  1997cites this paper
• bcl-2 protein expression in astrocytomas in relation to patient survival and p53 gene status

  1997cites this paper
• Long-term survivors of glioblastoma multiforme: clinical and molecular characteristics

  1996cites this paper
• Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas.

  1996cites this paper
• The molecular biology of brain tumors.

  1995cites this paper
• Epidermal growth factor-related peptides and their receptors in human malignancies.

  1995cites this paper
• RESEARCH ARTICLE Lack of Prognostic Significance of C-erbB-2 Expression in Low-and High-grade Astrocytomas

  year unknowninfluential citation