Glycogen Synthase Kinase-3β—Actively Inhibiting Hypertrophy

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Trends in Cardiovascular Medicine

• Publication date

  2007-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.TCM.2007.01.004
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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• Structure-function analysis of Frizzleds.

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• Myocardin Induces Cardiomyocyte Hypertrophy

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  1999cited by this paper
• A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.

  1998cited by this paper
• The cellular and molecular response of cardiac myocytes to mechanical stress.

  1997cited by this paper
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  1995cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1981cited by this paper
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