Immunohistochemical expression of DNA repair proteins in familial breast cancer differentiate BRCA2-associated tumors.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Clinical Oncology

• Publication date

  2005-10-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1200/JCO.2005.01.3698PMID 16234517
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cyclin E expression in breast cancer: predicting germline BRCA1 mutations, prognosis and response to treatment.

  2005cited by this paper
• Correlation of CHEK2 protein expression and c.1100delC mutation status with tumor characteristics among unselected breast cancer patients

  2005cited by this paper
• Comparative genomic hybridization profiles in human BRCA1 and BRCA2 breast tumors highlight differential sets of genomic aberrations.

  2005cited by this paper
• Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers

  2005cited by this paper
• RAD51 localization and activation following DNA damage.

  2004cited by this paper
• BRCA2 mutations in 154 finnish male breast cancer patients.

  2004cited by this paper
• Genetic alterations in hereditary breast cancer.

  2004cited by this paper
• Re: Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer.

  2004cited by this paper
• Re: Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast Cancer

  2004cited by this paper
• Is there still a role for neoadjuvant chemotherapy in head and neck cancer?

  2004cited by this paper
• The variant E233G of the RAD51D gene could be a low‐penetrance allele in high‐risk breast cancer families without BRCA1/2 mutations

  2004cited by this paper
• Breast Cancer Risk and the DNA Double-Strand Break End-Joining Capacity of Nonhomologous End-Joining Genes Are Affected by BRCA1

  2004cited by this paper
• Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer.

  2004cited by this paper
• Re: Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer.

  2004cited by this paper
• Histopathological features of breast tumours in BRCA1, BRCA2 and mutation-negative breast cancer families

  2004cited by this paper
• The CHEK2*1100delC variant acts as a breast cancer risk modifier in non-BRCA1/BRCA2 multiple-case families.

  2003cited by this paper
• BRCA2-dependent and independent formation of RAD51 nuclear foci

  2003cited by this paper
• Mutational analysis of BRCA1 and BRCA2 in Mediterranean Spanish women with early‐onset breast cancer: Identification of three novel pathogenic mutations

  2003cited by this paper
• Analysis of BRCA1 and BRCA2 genes in Spanish breast/ovarian cancer patients: A high proportion of mutations unique to Spain and evidence of founder effects

  2003cited by this paper
• DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

  2003cited by this paper
• Impact of germline BRCA1 mutations and overexpression of p53 on prognosis and response to treatment following breast carcinoma

  2003cited by this paper
• Immunohistochemical characteristics defined by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers.

  2003cited by this paper
• BRCA1 and BRCA2 mutation frequency in women evaluated in a breast cancer risk evaluation clinic.

  2002cited by this paper
• A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer.

  2002cited by this paper
• The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2.

  2002cited by this paper
• Comprehensive analysis of 989 patients with breast or ovarian cancer provides BRCA1 and BRCA2 mutation profiles and frequencies for the German population

  2002cited by this paper
• Linking DNA Damage to Cell Cycle Checkpoints

  2002cited by this paper
• Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts.

  2002cited by this paper
• Cancer susceptibility and the functions of BRCA1 and BRCA2.

  2002cited by this paper
• Review Cancer Susceptibility and the Functions of BRCA1 and BRCA2

  2002cited by this paper
• BRCA2 mutation analysis of 87 Spanish breast/ovarian cancer families.

  2001cited by this paper
• Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.

  2001cited by this paper
• The pathology of familial breast cancer: histological features of cancers in families not attributable to mutations in BRCA1 or BRCA2.

  2000cited by this paper
• Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases

  2000cited by this paper
• Evidence for Simultaneous Protein Interactions between Human Rad51 Paralogs*

  2000cited by this paper
• hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

  2000cited by this paper
• Molecular analysis of the BRCA1 and BRCA2 genes in 32 breast and/or ovarian cancer Spanish families

  2000cited by this paper
• BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

  2000cited by this paper
• Distinct molecular pathogeneses of early-onset breast cancers in BRCA1 and BRCA2 mutation carriers: a population-based study.

  1999cited by this paper
• Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.

  1999cited by this paper
• Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

  1999cited by this paper
• Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.

  1998cited by this paper
• Functions of the BRCA1 and BRCA2 genes.

  1998cited by this paper
• Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.

  1998cited by this paper
• Pathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases

  1997cited by this paper
• Mutations in BRCA1 and BRCA2 in breast cancer families: are there more breast cancer-susceptibility genes?

  1997cited by this paper
• Pathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases. Breast Cancer Linkage Consortium.

  1997cited by this paper
• Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage.

  1997cited by this paper
• Moderate frequency of BRCA1 and BRCA2 germ-line mutations in Scandinavian familial breast cancer.

  1997cited by this paper
• Identification of the breast cancer susceptibility gene BRCA2

  1995cited by this paper
• A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

  1994cited by this paper
• Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

  1993cited by this paper

• Role of MRE11 in DNA damage repair pathway dynamics and its diagnostic and prognostic significance in hereditary breast and ovarian cancer

  2025cites this paper
• Differential impact of cytoplasmic vs. nuclear RAD51 expression on breast cancer progression and patient prognosis

  2023cites this paper
• Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results

  2023cites this paper
• MYBL2-Driven Transcriptional Programs Link Replication Stress and Error-prone DNA Repair With Genomic Instability in Lung Adenocarcinoma

  2021cites this paper
• Predictive and Prognostic Value of DNA Damage Response Associated Kinases in Solid Tumors

  2020cites this paper
• HRness in Breast and Ovarian Cancers

  2020cites this paper
• Association of Cytokeratin 5 and Claudin 3 expression with BRCA1 and BRCA2 germline mutations in women with early breast cancer

  2019cites this paper
• Comprehensive Proteomic Profiling–derived Immunohistochemistry-based Prediction Models for BRCA1 and BRCA2 Germline Mutation-related Breast Carcinomas

  2018cites this paper
• Expression of DNA Damage Response Proteins and Associations with Clinicopathologic Characteristics in Chinese Familial Breast Cancer Patients with BRCA1/2 Mutations

  2018cites this paper
• Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption

  2017cites this paper
• RAD51 as a potential surrogate marker for DNA repair capacity in solid malignancies

  2017cites this paper
• Síndrome de cáncer de mama y ovario hereditario: Estudio in vitro de variantes BRCA1 y BRCA2 de significado biológico desconocido y búsqueda de nuevos genes responsables de este síndrome

  2016cites this paper
• Immunoprofile from tissue microarrays to stratify familial breast cancer patients

  2015cites this paper
• Proper genomic profiling of (BRCA1‐mutated) basal‐like breast carcinomas requires prior removal of tumor infiltrating lymphocytes

  2015cites this paper
• Deletion at 6q24.2–26 predicts longer survival of high‐grade serous epithelial ovarian cancer patients

  2014cites this paper
• Assessment of DNA-damage repair in breast cancer

  2014cites this paper
• MicroRNA expression signatures for the prediction of BRCA1/2 mutation‐associated hereditary breast cancer in paraffin‐embedded formalin‐fixed breast tumors

  2014cites this paper
• Are bilateral breast cancers and breast cancers coexisting with ovarian cancer different from solitary tumors? A pair‐matched immunohistochemical analysis aimed at intrinsic tumor phenotype

  2014cites this paper
• DNA Repair Pathway Gene Expression Score Correlates with Repair Proficiency and Tumor Sensitivity to Chemotherapy

  2014cites this paper
• Are bilateral breast cancers different from breast cancers coexisting with ovarian cancer? An immunohistochemical analysis aimed at intrinsic tumor phenotype.

  2013cites this paper
• MicroRNA-based molecular classification of non-BRCA1/2 hereditary breast tumours

  2013cites this paper
• The complex genetic landscape of familial breast cancer

  2013cites this paper
• Phenotypic characterization of hereditary epithelial ovarian cancer based on a tissue microarray study.

  2013cites this paper
• an Additional Method in the Selection of Patients Familial Breast/Ovarian Cancer and BRCA1/2 Genetic Screening: The Role of Immunohistochemistry as

  2013cites this paper
• A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization

  2013cites this paper
• Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

  2013cites this paper
• Expression pattern of ATM and cyclin D1 in ductal carcinoma, normal adjacent and normal breast tissues of Iranian breast cancer patients

  2012cites this paper
• MicroRNA expression profiles in hereditary breast cancer

  2012cites this paper
• High RAD51 mRNA expression characterize estrogen receptor‐positive/progesteron receptor‐negative breast cancer and is associated with patient's outcome

  2011cites this paper
• The Effect of a DNA Repair Gene on Cellular Invasiveness: Xrcc3 Over-Expression in Breast Cancer Cells

  2011cites this paper
• Rôles des paralogues de RAD51 humains dans la recombinaison homologue et le maintien de la stabilité du génome en mitose

  2011cites this paper
• Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins

  2010cites this paper
• Over-expression of RAD 51 occurs in aggressive prostate cancer

  2010cites this paper
• Pathology of hereditary breast cancer.

  2010cites this paper
• Subtypes of familial breast tumours revealed by expression and copy number profiling

  2010cites this paper
• DNA repair pathways and the effect of radiotherapy in breast cancer

  2009influential citation
• SELECÇÃO DAS MULHERES COM CRITÉRIOS PARA A PESQUISA DE MUTAÇÃO BRCA1/BRCA2 NO CENTRO HOSPITALAR DO PORTO

  2009cites this paper
• Overexpression of RAD51 occurs in aggressive prostatic cancer

  2009cites this paper
• Rad51 protein expression and survival in patients with glioblastoma multiforme.

  2009cites this paper
• Genome-wide linkage scan reveals three putative breast-cancer-susceptibility loci.

  2009cites this paper
• Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes

  2009cites this paper
• Immunofluorescence imaging of DNA damage response proteins: optimizing protocols for super-resolution microscopy.

  2009cites this paper
• The Molecular Pathology of Hereditary Breast Cancer

  2008cites this paper
• Hereditary breast cancer: from molecular pathology to tailored therapies

  2008cites this paper
• Distinct genomic aberration patterns are found in familial breast cancer associated with different immunohistochemical subtypes

  2008influential citation
• Tumor characteristics as an analytic tool for classifying genetic variants of uncertain clinical significance

  2008cites this paper
• Cyclin D1 expression analysis in familial breast cancers may discriminate BRCAX from BRCA2-linked cases

  2008cites this paper
• Stemming the tide of cancer for BRCA1/2 mutation carriers.

  2008cites this paper
• DNA repair by HDR in experimental tumorigenesis

  2008cites this paper
• ATM, RAD50 and p53 in breast cancer

  2008influential citation
• Genetic Markers in Breast Tumors with Hereditary Predisposition

  2008cites this paper
• Genetic susceptibility for breast cancer: how many more genes to be found?

  2007cites this paper
• Pathology of Breast Tumors in Hereditary Breast Cancer

  2007cites this paper
• CHEK 2 in Breast and Colorectal Cancer

  2007cites this paper
• The BRCA1/BRCA2/Rad51 complex is a prognostic and predictive factor in early breast cancer.

  2007cites this paper
• Bmc Cancer Prospective Study of Outcomes in Sporadic versus Hereditary Breast Cancer (posh): Study Protocol and the Posh Steering Group 3 Uk and 3 Posh Steering Group: See after Acknowledgement Section for Members and Roles

  2007cites this paper
• Hereditary breast cancer: pathobiology, clinical translation, and potential for targeted cancer therapeutics

  2007cites this paper
• Tumour characteristics, survival and prognostic factors of hereditary breast cancer from BRCA2-, BRCA1- and non-BRCA1/2 families as compared to sporadic breast cancer cases.

  2007cites this paper
• CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin?

  2007cites this paper
• Classification of missense variants of unknown significance in BRCA1 based on clinical and tumor information

  2007cites this paper
• Immunohistochemical classification of non-BRCA1/2 tumors identifies different groups that demonstrate the heterogeneity of BRCAX families

  2007cites this paper
• RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors.

  2007cites this paper
• Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH): study protocol

  2007cites this paper
• CHEK2 in Breast and Colorectal Cancer

  2007cites this paper
• Familial Breast/Ovarian Cancer and BRCA1/2 Genetic Screening: The Role of Immunohistochemistry as an Additional Method in the Selection of Patients

  2007cites this paper
• Breast Cancer in Three Dimensions: Revealing Telomere Dysfunction in Breast Cancer

  2006cites this paper
• Basic science (October 2005)

  2006cites this paper
• Risk of second malignant neoplasms among lymphoma patients with a family history of cancer

  2006cites this paper
• The expression of FHIT, PCNA and EGFR in benign and malignant breast lesions

  2006cites this paper
• Basal-like breast cancer and the BRCA1 phenotype

  2006cites this paper
• Pathology and gene expression of hereditary breast tumors associated with BRCA1, BRCA2 and CHEK2 gene mutations

  2006influential citation
• The CHEK2 gene and inherited breast cancer susceptibility

  2006cites this paper
• The Impact of Tumour Characteristics on Hereditary Breast Cancer Screening

  2006cites this paper