Cancer Chemopreventive Activity and Metabolism of Isoliquiritigenin, a Compound Found in Licorice

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cancer Prevention Research

• Publication date

  2010-01-12

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1158/1940-6207.CAPR-09-0049PMID 20068129PMCID PMC2818593
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Biotransformation of the Chemopreventive Agent 2′,4′,4-Trihydroxychalcone (Isoliquiritigenin) by UDP-Glucuronosyltransferases

  2008cited by this paper
• Biotransformation of the chemopreventive agent isoliquiritigenin by UDP-glucuronosyltransferases

  2008influential reference
• In Vitro Metabolism of Isoliquiritigenin by Human Liver Microsomes

  2008cited by this paper
• Quinone reductase induction as a biomarker for cancer chemoprevention.

  2006influential reference
• Cancer chemopreventive activity of sulforamate derivatives.

  2006cited by this paper
• Binding of Phytoestrogens to Rat Uterine Estrogen Receptors and Human Sex Hormone-binding Globulins

  2005cited by this paper
• Determination of liquiritigenin and isoliquiritigenin in Glycyrrhiza uralensis and its medicinal preparations by capillary electrophoresis with electrochemical detection.

  2004cited by this paper
• Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin.

  2004cited by this paper
• Chalcones as potent tyrosinase inhibitors: the effect of hydroxyl positions and numbers.

  2004cited by this paper
• In vitro assessment of intestinal permeability and hepatic metabolism of 4′-bromoflavone, a promising cancer chemopreventive agent

  2004cited by this paper
• Molecular cytotoxic mechanisms of anticancer hydroxychalcones.

  2004cited by this paper
• Induction of quinone reductase as a primary screen for natural product anticarcinogens.

  2004cited by this paper
• Cloning, characterization and regulation of a family of phi class glutathione transferases from wheat

  2003cited by this paper
• Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean).

  2003cited by this paper
• Estrogenic and antiproliferative activities of isoliquiritigenin in MCF7 breast cancer cells.

  2002influential reference
• Isoliquiritigenin suppresses pulmonary metastasis of mouse renal cell carcinoma.

  2002cited by this paper
• Studies on cancer chemoprevention by traditional folk medicines XXV. Inhibitory effect of isoliquiritigenin on azoxymethane-induced murine colon aberrant crypt focus formation and carcinogenesis.

  2002cited by this paper
• Apoptosis Induced by Isoliquiritigenin in Human Gastric Cancer MGC-803 Cells

  2001cited by this paper
• Apoptosis induced by isoliquiritigenin in human gastric cancer MGC-803 cells.

  2001cited by this paper
• Estrogen-like activity of glabrene and other constituents isolated from licorice root.

  2001cited by this paper
• Inhibition of xanthine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis

  2000cited by this paper
• In vitro inhibition of rat monoamine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis.

  2000cited by this paper
• Minor phenolics from Crinum bulbispermum bulbs.

  2000cited by this paper
• Screening for xenobiotic electrophilic metabolites using pulsed ultrafiltration-mass spectrometry.

  1999cited by this paper
• Cancer chemopreventive activity mediated by 4'-bromoflavone, a potent inducer of phase II detoxification enzymes.

  1999cited by this paper
• Three new flavonoids and antiallergic, anti-inflammatory constituents from the heartwood of Dalbergia odorifera.

  1998cited by this paper
• Cardiac effects of isoliquiritigenin.

  1997cited by this paper
• Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation.

  1997cited by this paper
• Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes.

  1997cited by this paper
• Isoliquiritigenin, a strong nod gene- and glyceollin resistance-inducing flavonoid from soybean root exudate

  1992influential reference

• Phytosynthesis of silver nanoparticles using Pterocarpus marsupium L. leaf extract and their antidiabetic, antioxidant, and antimicrobial activities

  2025cites this paper
• Biological insights and therapeutic potential of Glycyrrhiza uralensis and its bioactive compounds: an updated review

  2024cites this paper
• Unveiling the Essence of Isoliquiritigenin: Exploring Its Chemistry, Pharmacokinetics, and Pharmacological Potential

  2024influential citation
• Discovery of Natural Products for Cancer Prevention

  2024cites this paper
• Breast cancer prevention with liquiritigenin from licorice through the inhibition of aromatase and protein biosynthesis in high-risk women’s breast tissue

  2023cites this paper
• Estrogenic flavonoids and their molecular mechanisms of action.

  2022cites this paper
• Effects of 2,2′,4′-trihydroxychalcone on the proliferation, metastasis and apoptosis of A549 human lung cancer cells

  2022cites this paper
• Inhibition of Aromatase by Hops, Licorice Species, and their bioactive compounds in Postmenopausal Breast Tissue

  2022cites this paper
• Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology

  2021cites this paper
• Perspectives on the Role of Isoliquiritigenin in Cancer

  2021cites this paper
• Medicinal Uses of Licorice (Glycyrrhiza glabra L.): A Comprehensive Review

  2021cites this paper
• Dietary Compound Isoliquiritigenin, an Antioxidant from Licorice, Suppresses Triple-Negative Breast Tumor Growth via Apoptotic Death Program Activation in Cell and Xenograft Animal Models

  2020cites this paper
• Characterization and Cytotoxic Activity of Dalbergia latifolia Wood Extract

  2020cites this paper
• Anti-proliferative and cytotoxic activities of the flavonoid isoliquiritigenin in the human neuroblastoma cell line SH-SY5Y.

  2019cites this paper
• Enhancement of Oral Bioavailability and Anti-hyperuricemic Activity of Isoliquiritigenin via Self-Microemulsifying Drug Delivery System

  2019cites this paper
• Simultaneous Determination and Pharmacokinetic Characterization of Glycyrrhizin, Isoliquiritigenin, Liquiritigenin, and Liquiritin in Rat Plasma Following Oral Administration of Glycyrrhizae Radix Extract

  2019cites this paper
• Application of analytical chemistry in the quality evaluation of Glycyrrhiza Spp

  2019cites this paper
• Evidence for Chemopreventive and Resilience Activity of Licorice: Glycyrrhiza Glabra and G. Inflata Extracts Modulate Estrogen Metabolism in ACI Rats

  2018cites this paper
• Suppression of lung cancer progression by isoliquiritigenin through its metabolite 2, 4, 2’, 4’-Tetrahydroxychalcone

  2018cites this paper
• Herbs to support cancer care: Challenges and opportunities

  2018cites this paper
• Mechanistic evaluation of phytochemicals in breast cancer remedy: current understanding and future perspectives

  2018cites this paper
• Isoliquiritigenin inhibits mouse S180 tumors with a new mechanism that regulates autophagy by GSK‐3&bgr;/TNF‐&agr; pathway

  2018cites this paper
• Medicinal Plants as a Potential Source of Chemopreventive Agents

  2018cites this paper
• Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme.

  2017cites this paper
• Antitumor effects and the underlying mechanism of licochalcone A combined with 5-fluorouracil in gastric cancer cells

  2017cites this paper
• iRGD-modified lipid–polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability

  2017cites this paper
• The comparison of neuroprotective effects of isoliquiritigenin and its Phase I metabolites against glutamate-induced HT22 cell death.

  2016cites this paper
• Isoliquiritigenin suppresses human T Lymphocyte activation via covalently binding cysteine 46 of IκB kinase

  2016cites this paper
• Botanicals and Their Bioactive Phytochemicals for Women’s Health

  2016cites this paper
• Naturally occurring chalcones and their biological activities

  2016cites this paper
• Cytoprotective Role of Dietary Phytochemicals Against Cancer Development via Induction of Phase II and Antioxidant Enzymes

  2016cites this paper
• Chalcones as Promising Lead Compounds on Cancer Therapy.

  2015cites this paper
• Detection of reactive metabolites using isotope-labeled glutathione trapping and simultaneous neutral loss and precursor ion scanning with ultra-high-pressure liquid chromatography triple quadruple mass spectrometry.

  2015cites this paper
• Development of Safe and Effective Botanical Dietary Supplements

  2015cites this paper
• Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.

  2015cites this paper
• Separation and characterization of phenolic compounds and triterpenoid saponins in licorice (Glycyrrhiza uralensis) using mobile phase-dependent reversed-phase×reversed-phase comprehensive two-dimensional liquid chromatography coupled with mass spectrometry.

  2015cites this paper
• Plasma Pharmacokinetics of Polyphenols in a Traditional Japanese Medicine, Jumihaidokuto, Which Suppresses Propionibacterium acnes-Induced Dermatitis in Rats

  2015cites this paper
• 4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent. From discovery to initial validation in an in vivo metastasis model.

  2015cites this paper
• Chemopreventive Effects of Licorice and Its Components

  2015cites this paper
• Structural elucidation of in vivo metabolites of isobavachalcone in rat by LC-ESI-MS(n) and LC-NMR.

  2015cites this paper
• Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.

  2015cites this paper
• Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation

  2015cites this paper
• Title Dietary compound Isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF 1 demethylation

  2015cites this paper
• A Review: The Pharmacology of Isoliquiritigenin

  2015influential citation
• Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice

  2014cites this paper
• Protective effects of dehydroglyasperin c against carbon tetrachloride-induced liver damage in mice

  2014cites this paper
• MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin

  2014cites this paper
• Phytochemical importance of medicinal plants as potential sources of anticancer agents

  2014cites this paper
• Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues: promising options for prevention and treatment of uterine fibroids?

  2014cites this paper
• Antitumor Activities of Widely-used Chinese Herb—Licorice

  2014cites this paper
• Isoliquiritigenin Induces Apoptosis and Inhibits Xenograft Tumor Growth of Human Lung Cancer Cells by Targeting Both Wild Type and L858R/T790M Mutant EGFR*

  2014cites this paper
• Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions.

  2014cites this paper
• An Update on Antitumor Activity of Naturally Occurring Chalcones

  2013cites this paper
• Assessment of the antineoplastic potential of chalcones in animal models.

  2013cites this paper
• Inhibitory effects of isoliquiritigenin on the migration and invasion of human breast cancer cells

  2013cites this paper
• KAVA Chalcone, Flavokawain A, Inhibits Urothelial Tumorigenesis in the UPII-SV40T Transgenic Mouse Model

  2013cites this paper
• Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay.

  2013cites this paper
• Modulation of Estrogen Metabolism by Hops Extracts and Bioactive Compounds as Analyzed by LC-MS-MS

  2013cites this paper
• The Role of Direct and Indirect Polyphenolic Antioxidants in Protection Against Oxidative Stress

  2013cites this paper
• Dietary Compound Isoliquiritigenin Inhibits Breast Cancer Neoangiogenesis via VEGF/VEGFR-2 Signaling Pathway

  2013cites this paper
• Title Dietary Compound Isoliquiritigenin Inhibits Breast Cancer Growth And Neoangiogenesis Via Blocking Vegf / vegfr-2 Signaling Pathway

  2013cites this paper
• Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo.

  2013cites this paper
• Evaluation of Estrogenic Activity of Licorice Species in Comparison with Hops Used in Botanicals for Menopausal Symptoms

  2013cites this paper
• Six New Chalcones from Angelica keiskei Inducing Adiponectin Production in 3T3-L1 Adipocytes

  2012cites this paper
• Cancer Chemopreventive Activity of Higher Plants

  2012cites this paper
• Inverse Virtual Screening allows the discovery of the biological activity of natural compounds.

  2012cites this paper
• Modulation of Estrogen Chemical Carcinogenesis by Botanical Supplements used for Postmenopausal Women's Health.

  2012cites this paper
• Antioxidant activities of licorice-derived prenylflavonoids

  2012cites this paper
• From Single Compounds to Herbal Extract: A Strategy to Systematically Characterize the Metabolites of Licorice in Rats

  2011influential citation
• Microsoft Word-49449831-file00

  2011influential citation
• Dietary chalcones with chemopreventive and chemotherapeutic potential

  2011cites this paper
• Urinary Metabolites of Isoliquiritigenin in Wistar Rats using UHPLC–TOF–MS-based Xenometabolomics

  2011cites this paper
• Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity.

  2011cites this paper
• Chalcone-based inhibitors against hypoxia-inducible factor 1--structure activity relationship studies.

  2011cites this paper
• Isoliquiritigenin from licorice root suppressed neovascularisation in experimental ocular angiogenesis models

  2011cites this paper
• 18beta-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures.

  2011cites this paper
• Herb-drug interactions: Focus on metabolic enzymes and transporters

  2011cites this paper
• Reinvestigation of the synthesis of isoliquiritigenin: application of Horner-Wadsworth-Emmons reaction and Claisen-Schmidt condensation.

  2011cites this paper
• Inhibition of liver X receptor-α-dependent hepatic steatosis by isoliquiritigenin, a licorice antioxidant flavonoid, as mediated by JNK1 inhibition.

  2010cites this paper