Mathematical models for ligand-receptor binding. Real sites, ghost sites.

In the basic life sciences the term "model" implies a physical, chemical, or molecular construct that provides a representation for the interpretation of experimental observations. To the statistician, however, a model is a mathematical expression for correlating data, which may or may not have roots in a molecular picture. With regard to ligand-receptor interactions, the mathematical model used plays a crucial role in extrapolations of binding measurements. Regardless of the statistical goodness of fit of data to an equation, the relationships of the parameters of a mathematical formalism to the molecular features of ligand-receptor complexes are generally very complex. Oversimplified interpretations of the molecular significance of the constants derived from binding measurements are unwarranted, unless one has independent information from molecular probes.

• Publication year

  1984

• Venue

  Journal of Biological Chemistry

• Publication date

  1984-08-25

• Fields of study

  Chemistry, Mathematics, Medicine

• Identifiers
  DOI 10.1016/s0021-9258(18)90927-0PMID 6469955
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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