Protein sequence database for pathogenic arenaviruses

BackgroundArenaviruses are a family of rodent-borne viruses that cause several hemorrhagic fevers. These diseases can be devastating and are often lethal. Herein, to aid in the design and development of diagnostics, treatments and vaccines for arenavirus infections, we have developed a database containing protein sequences from the seven pathogenic arenaviruses (Junin, Guanarito, Sabia, Machupo, Whitewater Arroyo, Lassa and LCMV).ResultsThe database currently contains a non-redundant set of 333 protein sequences which were manually annotated. All entries were linked to NCBI and cited PubMed references. The database has a convenient query interface including BLAST search. Sequence variability analyses were also performed and the results are hosted in the database.ConclusionThe database is available at http://epitope.liai.org:8080/projects/arena and can be used to aid in studies that require proteomic information from pathogenic arenaviruses.

• Publication year

  2007

• Venue

  Immunome Research

• Publication date

  2007-02-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/1745-7580-3-1PMID 17288609PMCID 1803765
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phylogeny and evolution of old world arenaviruses.

  2006cited by this paper
• A Mathematical Theory of Communication

  2006cited by this paper
• The Immune Epitope Database and Analysis Resource: From Vision to Blueprint

  2005influential reference
• The design and implementation of the immune epitope database and analysis resource

  2005influential reference
• Contribution of LCMV towards deciphering biology of quasispecies in vivo.

  2002cited by this paper
• Hemorrhagic fever viruses as biological weapons: medical and public health management.

  2002cited by this paper
• Arenaviridae: The viruses and their replication

  2001cited by this paper
• Fatal illnesses associated with a new world arenavirus--California, 1999-2000.

  2000cited by this paper
• Venezuelan hemorrhagic fever: clinical and epidemiological studies of 165 cases.

  1998cited by this paper
• Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group.

  1998cited by this paper
• Phylogenetic analysis of the Arenaviridae: patterns of virus evolution and evidence for cospeciation between arenaviruses and their rodent hosts.

  1997cited by this paper
• Congenital lymphocytic choriomeningitis virus syndrome: a disease that mimics congenital toxoplasmosis or Cytomegalovirus infection.

  1997cited by this paper
• The phylogeny of New World (Tacaribe complex) arenaviruses.

  1996cited by this paper
• Isolation and characterization of Whitewater Arroyo virus, a novel North American arenavirus.

  1996cited by this paper
• Antiviral treatment of Argentine hemorrhagic fever.

  1994cited by this paper
• CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

  1994cited by this paper
• New arenavirus isolated in Brazil.

  1994cited by this paper
• Hydrocephalus complicating lymphocytic choriomeningitis virus infection

  1993cited by this paper
• Congenital lymphocytic choriomeningitis virus infection in twins

  1993cited by this paper
• Theoretical and Experimental Insights into Immunology

  1992cited by this paper
• Venezuelan haemorrhagic fever.

  1991cited by this paper
• The completed sequence of lymphocytic choriomeningitis virus reveals a unique RNA structure and a gene for a zinc finger protein.

  1989cited by this paper
• Epidemiology and control of Lassa fever.

  1987cited by this paper
• Lassa fever. Effective therapy with ribavirin.

  1986cited by this paper
• Protein structure of lymphocytic choriomeningitis virus: evidence for a cell-associated precursor of the virion glycopeptides.

  1979cited by this paper
• Clinical and epidemiological patterns of Argentine haemorrhagic fever.

  1975cited by this paper
• A mathematical theory of communication

  1948cited by this paper

• Genome-Wide Prediction of Potential Vaccine Candidates for Campylobacter jejuni Using Reverse Vaccinology

  2019cites this paper
• Population entropies estimates of proteins

  2017cites this paper
• Assembly of Arena virus an Ultra structural Perspective

  2016cites this paper
• Prototype of oligonucleotide microarray for detection of pathogens relating to arena- and filoviridae families

  2015cites this paper
• Arenavirus Variations Due to Host-Specific Adaptation

  2013cites this paper
• Pathogenic Old World Arenaviruses

  2013cites this paper
• Argentine Hemorrhagic Fever

  2013cites this paper
• Genomic analysis and pathogenic characteristics of lymphocytic choriomeningitis virus strains isolated in Japan.

  2012cites this paper
• Junín virus. A XXI century update.

  2011cites this paper
• Conserved Residues in Lassa Fever Virus Z Protein Modulate Viral Infectivity at the Level of the Ribonucleoprotein

  2011cites this paper
• Comparative Pathogenesis and Systems Biology for Biodefense Virus Vaccine Development

  2010cites this paper
• Coverage of Related Pathogenic Species by Multivalent and Cross-Protective Vaccine Design: Arenaviruses as a Model System

  2010cites this paper
• A Multivalent and Cross-Protective Vaccine Strategy against Arenaviruses Associated with Human Disease

  2009cites this paper
• Unusual Molecular Architecture of the Machupo Virus Attachment Glycoprotein

  2009cites this paper
• and Application to the Diagnosis of Hemorrhagic Fever Caused by South 2

  2009cites this paper
• Characterization of Monoclonal Antibodies to Junin Virus Nucleocapsid Protein and Application to the Diagnosis of Hemorrhagic Fever Caused by South American Arenaviruses

  2009cites this paper
• Adaptive immunity to Lymphocytic choriomeningitis virus: new insights into antigenic determinants

  2007cites this paper
• Simultaneous Analysis of In Vivo CD8+ T Cell Cytotoxicity Against Multiple Epitopes using Multicolor Flow Cytometry

  2007cites this paper