Prion protein ablation increases cellular aggregation and embolization contributing to mechanisms of metastasis

No abstract is available for this paper.

• Publication year

  2009

• Venue

  International Journal of Cancer

• Publication date

  2009-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/ijc.24425PMID 19444918
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Invasion of tumorigenic HT1080 cells is impeded by blocking or downregulating the 37-kDa/67-kDa laminin receptor.

  2008cited by this paper
• Physiology of the prion protein.

  2008influential reference
• The 67 kDa laminin receptor: structure, function and role in disease.

  2008cited by this paper
• Cellular prion protein promotes proliferation and G1/S transition of human gastric cancer cells SGC7901 and AGS

  2007cited by this paper
• Efficacy of adjuvant chemotherapy according to Prion protein expression in patients with estrogen receptor-negative breast cancer.

  2007cited by this paper
• Silencing of prion protein sensitizes breast adriamycin-resistant carcinoma cells to TRAIL-mediated cell death.

  2007cited by this paper
• Cellular prion protein interaction with vitronectin supports axonal growth and is compensated by integrins

  2007cited by this paper
• STI1 promotes glioma proliferation through MAPK and PI3K pathways

  2007cited by this paper
• Cellular prion protein promotes invasion and metastasis of gastric cancer

  2006cited by this paper
• Overexpression of PrPC and Its Antiapoptosis Function in Gastric Cancer

  2006cited by this paper
• Interaction of Cellular Prion and Stress-Inducible Protein 1 Promotes Neuritogenesis and Neuroprotection by Distinct Signaling Pathways

  2005cited by this paper
• Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation

  2005cited by this paper
• Overexpression and significance of prion protein in gastric cancer and multidrug‐resistant gastric carcinoma cell line SGC7901/ADR

  2005cited by this paper
• Prion Protein Prevents Human Breast Carcinoma Cell Line from Tumor Necrosis Factor α-Induced Cell Death

  2004cited by this paper
• Cell-surface prion protein interacts with glycosaminoglycans.

  2002cited by this paper
• Unique Ability of Integrin αvβ3 to Support Tumor Cell Arrest under Dynamic Flow Conditions* 210

  2002cited by this paper
• Integrins: bidirectional, allosteric signaling machines.

  2002cited by this paper
• Stress‐inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection

  2002cited by this paper
• Unique ability of integrin alpha(v)beta 3 to support tumor cell arrest under dynamic flow conditions.

  2002cited by this paper
• PrP‐dependent cell adhesion in N2a neuroblastoma cells

  2002cited by this paper
• Tail Vein Assay of Cancer Metastasis

  2001cited by this paper
• The 37‐kDa/67‐kDa laminin receptor acts as the cell‐surface receptor for the cellular prion protein

  2001cited by this paper
• Integrin activation controls metastasis in human breast cancer.

  2001cited by this paper
• Prion Protein Protects Human Neurons against Bax-mediated Apoptosis*

  2001cited by this paper
• Laminin‐induced PC‐12 cell differentiation is inhibited following laser inactivation of cellular prion protein

  2000cited by this paper
• Immobilized platelets support human colon carcinoma cell tethering, rolling, and firm adhesion under dynamic flow conditions.

  2000cited by this paper
• Cellular prion protein binds laminin and mediates neuritogenesis.

  2000cited by this paper
• Transfection of constitutively active mitogen-activated protein/extracellular signal-regulated kinase kinase confers tumorigenic and metastatic potentials to NIH3T3 cells.

  2000cited by this paper
• Mechanisms and Consequences of Affinity Modulation of Integrin αVβ3 Detected with a Novel Patch-engineered Monovalent Ligand*

  1999cited by this paper
• Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand.

  1999cited by this paper
• Integrins, Oncogenes, and Anchorage Independence

  1997cited by this paper
• Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity.

  1997cited by this paper
• Stimulation of glioma-cell migration by laminin and inhibition by anti-alpha3 and anti-beta1 integrin antibodies.

  1996cited by this paper
• Role of 3 Integrins in Melanoma Cell Adhesion to Activated Platelets under Flow (*)

  1996cited by this paper
• Stimulation of glioma‐cell migration by laminin and inhibition by anti‐α3 and anti‐β1 integrin antibodies

  1996cited by this paper
• Role of Platelets, Thrombin, Integrin llb-llla, Fibronectin and Von Willebrand Factor on Tumor Adhesion in Vitro and Metastasis in Vivo

  1995cited by this paper
• 129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal

  1994cited by this paper
• Mice devoid of PrP are resistant to scrapie.

  1993cited by this paper
• Platelets and cancer metastasis: A causal relationship?

  1992cited by this paper
• Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

  1992cited by this paper
• Structure of Vitronectin and its Biological Role in Haemostasis

  1991cited by this paper
• A metalloproteinase, capable of destroying cultured brain tissue isolated from rat glioma cells.

  1991cited by this paper
• The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors.

  1989cited by this paper
• Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ.

  1989cited by this paper
• Novel purification of vitronectin from human plasma by heparin affinity chromatography.

  1988cited by this paper
• Laminin-nidogen complex. Extraction with chelating agents and structural characterization.

  1987cited by this paper
• Oligosaccharide modification by swainsonine treatment inhibits pulmonary colonization by B16-F10 murine melanoma cells.

  1986cited by this paper
• Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

  1983cited by this paper
• Tumor invasion and the extracellular matrix.

  1983cited by this paper
• Experimental model for quantitative study of metastasis.

  1980cited by this paper
• Properties of a basement membrane-related glycoprotein synthesized in culture by a mouse embryonal carcinoma-derived cell line.

  1979cited by this paper
• Binding of soluble form of fibroblast surface protein, fibronectin, to collagen

  1977cited by this paper

• Targeting the Cellular Prion Protein as a Biomarker for Stem Cells, Cancer, and Regeneration

  2025cites this paper
• Copper homeostasis-associated gene PRNP regulates ferroptosis and immune infiltration in breast cancer

  2023cites this paper
• The Role of Cellular Prion Protein in Promoting Stemness and Differentiation in Cancer

  2021cites this paper
• The Role of Cellular Prion Protein in Cancer Biology: A Potential Therapeutic Target

  2021cites this paper
• The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration

  2018cites this paper
• Functional genomic screens for novel metastasis suppressor genes in breast and prostate cancer models

  2018cites this paper
• Loss of prion protein is associated with the development of insulin resistance and obesity.

  2017cites this paper
• Prion Proteinlerinin Biyolojisi

  2017cites this paper
• [Heparan sulphates, amyloidosis and neurodegeneration].

  2017cites this paper
• Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration

  2016cites this paper
• Predicting cancer-relevant proteins using an improved molecular similarity ensemble approach

  2016cites this paper
• Prion protein binding to HOP modulates the migration and invasion of colorectal cancer cells

  2016cites this paper
• Zinc transporter ZIP 10 forms a heteromer with ZIP 6 which regulates embryonic development and cell migration

  2016cites this paper
• Role of polymorphic variants of the prion protein on the resistance-susceptibility to prion infection

  2014cites this paper
• CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cancer.

  2013cites this paper
• Tumor and Stem Cell Biology CD 44-Positive Cancer Stem Cells Expressing Cellular Prion Protein Contribute to Metastatic Capacity in Colorectal Cancer

  2013cites this paper
• Roles of the cellular prion protein in the regulation of cell-cell junctions and barrier function

  2013cites this paper
• Potential roles for prions and protein-only inheritance in cancer

  2012cites this paper
• Copper is toxic to PrP-ablated mice and exacerbates disease in a mouse model of E200K genetic prion disease.

  2012cites this paper
• Prion Protein Expression Regulates Embryonic Stem Cell Pluripotency and Differentiation

  2011cites this paper