Design and Synthesis of α-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPARα/γ Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Medicinal Chemistry

• Publication date

  2005-06-04

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/JM0502135
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• No references are available for this paper.

• Computational assessment of substituted 2-Mercaptobenzimidazole Schiff bases derivatives targeting α-amylase, α-glucosidase, and PPAR-γ receptor in Type 2 Diabetes Mellitus

  2025cites this paper
• Rational in silico design of PPARγ agonists for type 2 diabetes: an integrated study using pharmacophore modeling, 3D-QSAR, molecular docking, MD simulations, DFT, and toxicity prediction.

  2025cites this paper
• Microwave-Assisted Facile Synthesis of 1,2-Benzisoxazoles, Isoxazoloquinolines, and Isothiazoloquinolines in [BMIM(SO2Cl)][OTs] Ionic Liquid as a Recyclable System

  2025cites this paper
• Exploring fingerprints for antidiabetic therapeutics related to peroxisome proliferator-activated receptor gamma (PPARγ) modulators: A chemometric modeling approach

  2024cites this paper
• Rational design of thiazolidine-4-one-gallic acid hybrid derivatives as selective partial PPARγ modulators: an in-silico approach for type 2 diabetes treatment

  2023cites this paper
• Synthesis, Biological Evaluation, and Computational Studies of 6-Fluoro-3-(Piperidin-4-yl)-1,2-Benzisoxazole Sulfonamide Conjugates

  2023cites this paper
• Binding of Per- and Polyfluoro-alkyl Substances to Peroxisome Proliferator-Activated Receptor Gamma

  2021cites this paper
• Thiazolidinedione "Magic Bullets" Simultaneously Targeting PPARγ and HDACs: Design, Synthesis, and Investigations of their In Vitro and In Vivo Antitumor Effects.

  2021cites this paper
• Pd-catalyzed cross-electrophile Coupling/C–H alkylation reaction enabled by a mediator generated via C(sp3)–H activation†

  2021cites this paper
• A Theoretical Model to Study the Interactions of Xanthene-1,2, 3-Triazolyl-N-Riboside and Xanthene-Piperidinyl-Benzisoxazole Based Conjugates With the Insulin: Design, Docking and ADME Studies

  2020cites this paper
• Convenient method for the synthesis of some novel chiral methyl 2‐( 2‐oxo‐2H ‐benzo[e][1,3]oxazin‐3( 4H )‐yl)propanoate derivatives and biological evaluation of their antioxidant, cytotoxic, and molecular docking properties

  2020cites this paper
• Oncoglabrinol C, a new flavan from Oncocalyx glabratus protects endothelial cells against oxidative stress and apoptosis, and modulates hepatic CYP3A4 activity

  2020cites this paper
• In silico docking studies and synthesis of new phosphoramidate derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole as potential antimicrobial agents

  2020cites this paper
• Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-γ agonists and anti-inflammatory COX-2 selective inhibitors.

  2019cites this paper
• Convenient synthesis of O-functionalized mandelic acids via Lewis acid mediated transformation of 1,3-dioxolan-4-ones

  2019cites this paper
• Type II diabetes mellitus and obesity: Common links, existing therapeutics and future developments

  2019cites this paper
• Silver-Catalyzed Asymmetric Insertion into Phenolic O-H Bonds using Aryl Diazoacetates and Theoretical Mechanistic Studies.

  2019cites this paper
• Enantioselective Carbene Insertion into O–H of Phenols with Chiral Palladium/2,2′-Biimidazole Complexes

  2019cites this paper
• Water Pharmacophore: Designing Ligands using Molecular Dynamics Simulations with Water

  2018cites this paper
• Design, synthesis and molecular docking of thiazolidinedione based benzene sulphonamide derivatives containing pyrazole core as potential anti-diabetic agents.

  2018cites this paper
• 1,2-Benzisoxazole-3-acetamide derivatives as dual agents for DPP-IV inhibition and anticancer activity

  2018cites this paper
• Transition metal-free N-fluoroalkylation of amines using cyanurate activated fluoroalcohols.

  2017cites this paper
• X-ray crystal structure of rivoglitazone bound to PPARγ and PPAR subtype selectivity of TZDs.

  2017cites this paper
• Synthesis, molecular docking and anti-diabetic evaluation of 2,4-thiazolidinedione based amide derivatives.

  2017cites this paper
• Benzisoxazole: a privileged scaffold for medicinal chemistry.

  2017cites this paper
• The Synthesis of Chiral α-Aryl α-Hydroxy Carboxylic Acids via RuPHOX-Ru Catalyzed Asymmetric Hydrogenation

  2017cites this paper
• New tetrazoloquinolinyl methoxyphenyl-4-thiazolidinones: synthesis and antihyperglycemic evaluation

  2017cites this paper
• Design and synthesis of novel Y-shaped barbituric acid derivatives as PPARγ activators.

  2016cites this paper
• Evaluation of selected 3D virtual screening tools for the prospective identification of peroxisome proliferator-activated receptor (PPAR) γ partial agonists.

  2016cites this paper
• A zinc-catalyzed oxidative reaction of ynamides with phenols and thiophenols: highly site-selective synthesis of versatile α-aryloxy amides and α-arylthio amides

  2016cites this paper
• Systematic evaluation of methyl ester bioisosteres in the context of developing alkenyldiarylmethanes (ADAMs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) for anti-HIV-1 chemotherapy.

  2016cites this paper
• Polyfluorinated ethanes as versatile fluorinated C2-building blocks for organic synthesis.

  2015cites this paper
• Incorporating Hotspot Mapping and Allostery in Structure Based Drug Design.

  2015cites this paper
• Characterization of covalent bond formation between PPARγ and oxo-fatty acids.

  2015cites this paper
• Biomass-involved, facile and one-pot synthesis of N-aryl-2(3H)-benzoxazolones from methyl 3-dehydroshikimiate

  2014cites this paper
• Triglyceride-lowering agents.

  2014cites this paper
• Enantioselective palladium-catalyzed insertion of α-aryl-α-diazoacetates into the O-H bonds of phenols.

  2014cites this paper
• N‐Benzoyl‐L‐Threonine‐Isopropyl‐Ester‐Mediated Crystallization‐Induced Dynamic Resolution of α‐Bromo Arylacetates for the Asymmetric Synthesis of α‐Thio and α‐Oxy Arylacetates

  2014cites this paper
• Reinvestigations into synthesis of allyldithiocarbamates and their intramolecular cyclization: synthesis and antihyperglycemic activity of 2-thioxothiazolidine-4-alkanoates

  2014cites this paper
• Some molecular targets for antihyperlipidemic drug research.

  2014cites this paper
• Refinement of the Docking Component of Virtual Screening for PPAR

  2013cites this paper
• Synthesis of 3-alkylbenzoxazolones from N-alkyl-N-arylhydroxylamines by contiguous O-trichloroacetylation, trichloroacetoxy ortho-shift, and cyclization sequence.

  2013cites this paper
• New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression.

  2013cites this paper
• SAR and Computer-Aided Drug Design Approaches in the Discovery of Peroxisome Proliferator-Activated Receptor γ Activators: A Perspective

  2013cites this paper
• Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists

  2012cites this paper
• Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.

  2012cites this paper
• Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice.

  2012cites this paper
• Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists.

  2012cites this paper
• Docking, synthesis and anti-diabetic activity of novel sulfonylhydrazone derivatives designed as PPAR-gamma agonists.

  2012cites this paper
• Structural insight into the crucial role of ligand chirality in the activation of PPARs by crystallographic methods.

  2011cites this paper
• Aromatic Ketones Containing One Pivaloyl Group

  2011cites this paper
• Phytochemicals as Modulators of PPARs and RXRs

  2011cites this paper
• Aromatic Ketones Containing One Propionyl Group

  2011cites this paper
• A Combined Ligand‐ and Structure‐Based Virtual Screening Protocol Identifies Submicromolar PPARγ Partial Agonists

  2011cites this paper
• Discovery and development of selective PPARγ modulators as safe and effective antidiabetic agents

  2010cites this paper
• Heterocycles from Hydroxylamines and Hydroxamic Acids

  2010cites this paper
• 4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations.

  2009cites this paper
• Virtual Screening as a Technique for PPAR Modulator Discovery

  2009cites this paper
• New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function.

  2009cites this paper
• In Vivo Imaging Reveals Selective Peroxisome Proliferator Activated Receptor Modulator Activity of the Synthetic Ligand 3-(1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid (MK-886)

  2008cites this paper
• Peroxisome Proliferator‐Activated Receptor γ Modulation for the Treatment of Type 2 Diabetes

  2008cites this paper
• Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design.

  2008cites this paper
• The Differential Interactions of Peroxisome Proliferator-Activated Receptor γ Ligands with Tyr473 Is a Physical Basis for Their Unique Biological Activities

  2008cites this paper
• NSAIDs revisited: putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARgamma).

  2008cites this paper
• The Endocrine Disruptor Monoethyl-hexyl-phthalate Is a Selective Peroxisome Proliferator-activated Receptor γ Modulator That Promotes Adipogenesis*

  2007cites this paper
• Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators.

  2007cites this paper
• 20-Carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors α and γ

  2007cites this paper
• Ajulemic Acid, a Synthetic Nonpsychoactive Cannabinoid Acid, Bound to the Ligand Binding Domain of the Human Peroxisome Proliferator-activated Receptor γ*

  2007cites this paper
• Sulfonylureas and Glinides Exhibit Peroxisome Proliferator-Activated Receptor γ Activity: A Combined Virtual Screening and Biological Assay Approach

  2007cites this paper
• Procede de preparation stereoselective de (-)-halofenates et d'intermediaires de ces derniers

  2006cites this paper
• Nuclear Hormone Receptor Modulators for the Treatment of Diabetes and Dyslipidemia

  2006cites this paper
• Drug therapy of the metabolic syndrome: minimizing the emerging crisis in polypharmacy

  2006cites this paper
• Sulfonylureas and Glinides Exhibit PPAR γ Activity: A Combined Virtual Screening and Biological Assay Approach*

  2006cites this paper
• Selective PPAR modulators, dual and pan PPAR agonists: multimodal drugs for the treatment of Type 2 diabetes and atherosclerosis

  2006cites this paper
• Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARalpha, PPARgamma, and adipocyte differentiation in vitro.

  2006cites this paper
• Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings.

  2006cites this paper