Structure and receptor activity for classical cannabinoids.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Current Medicinal Chemistry

• Publication date

  1999-08-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/CHIN.199945330PMID 10469886
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structure elucidation and conformational properties of synthetic cannabinoids (-)-2-(6a,7,10,10a-tetrahydro-6,6,9-trimethyl-1-hydroxy-6H-dibe nzo [b,d]pyranyl)-2-hexyl-1,3-dithiolane and its methylated analog.

  1999cited by this paper
• Structure and Receptor Activity for Classical Cannabinoids

  1999cited by this paper
• Potent cyano and carboxamido side-chain analogues of 1', 1'-dimethyl-delta8-tetrahydrocannabinol.

  1998cited by this paper
• Synthesis of a tetracyclic, conformationally constrained analogue of delta8-THC.

  1998cited by this paper
• Enantioselective synthesis and pharmacology of 11-hydroxy-(1'S,2'R)-dimethylheptyl-delta 8-THC.

  1998cited by this paper
• Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols.

  1998cited by this paper
• Classical/nonclassical hybrid cannabinoids: southern aliphatic chain-functionalized C-6beta methyl, ethyl, and propyl analogues.

  1998cited by this paper
• Comparison of cannabinoid binding sites in guinea‐pig forebrain and small intestine

  1998cited by this paper
• Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: synthesis and characterization of a series of O,2-propano-delta 8-tetrahydrocannabinol analogs.

  1997cited by this paper
• A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2.

  1996cited by this paper
• Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.

  1996cited by this paper
• Agonist-antagonist characterization of 6'-cyanohex-2'-yne-delta 8-tetrahydrocannabinol in two isolated tissue preparations.

  1996cited by this paper
• Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor.

  1996cited by this paper
• Unsaturated side chain beta-11-hydroxyhexahydrocannabinol analogs.

  1996cited by this paper
• Pharmacological evaluation of dimethylheptyl analogs of delta 9-THC: reassessment of the putative three-point cannabinoid-receptor interaction.

  1995cited by this paper
• Classical/non-classical cannabinoid hybrids; stereochemical requirements for the southern hydroxyalkyl chain.

  1995cited by this paper
• Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.

  1995cited by this paper
• A novel class of potent tetrahydrocannabinols (THCS): 2'-yne-delta 8- and delta 9-THCS.

  1995cited by this paper
• The design, synthesis and testing of desoxy-CBD: further evidence for a region of steric interference at the cannabinoid receptor.

  1995cited by this paper
• A review of recent advances in cannabinoid research and the 1994 International Symposium on Cannabis and the Cannabinoids.

  1995cited by this paper
• Variation of the alkyl side chain in delta 8-THC.

  1995cited by this paper
• Construction of a 3D model of the cannabinoid CB1 receptor: determination of helix ends and helix orientation.

  1995cited by this paper
• Conformational analysis of the prototype nonclassical cannabinoid CP-47,497, using 2D NMR and computer molecular modeling.

  1994cited by this paper
• Synthesis and pharmacological properties of 11-hydroxy-3-(1',1'-dimethylheptyl)hexahydrocannabinol: a high-affinity cannabinoid agonist.

  1994cited by this paper
• (-)-11-Hydroxy-7'-isothiocyanato-1',1'-dimethylheptyl-delta 8-THC: a novel, high-affinity irreversible probe for the cannabinoid receptor in the brain.

  1994cited by this paper
• Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities.

  1993cited by this paper
• Pharmacological evaluation of iodo and nitro analogs of delta 8-THC and delta 9-THC.

  1993cited by this paper
• Molecular characterization of a peripheral receptor for cannabinoids

  1993cited by this paper
• Structure-activity relationships for cannabinoid receptor-binding and analgesic activity: studies of bicyclic cannabinoid analogs.

  1993cited by this paper
• Characterization of a region of steric interference at the cannabinoid receptor using the active analog approach.

  1993cited by this paper
• 5'-Azido-delta 8-THC: a novel photoaffinity label for the cannabinoid receptor.

  1992cited by this paper
• A novel probe for the cannabinoid receptor.

  1992cited by this paper
• Synthesis and pharmacological evaluation of ether and related analogues of delta 8-, delta 9-, and delta 9,11-tetrahydrocannabinol.

  1991cited by this paper
• Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study

  1991cited by this paper
• A rational search for the separation of psychoactivity and analgesia in cannabinoids.

  1991cited by this paper
• Pharmacological evaluation of halogenated delta 8-THC analogs.

  1991cited by this paper
• Modeling the cannabinoid receptor: a three-dimensional quantitative structure-activity analysis.

  1991cited by this paper
• A computergraphic investigation into the pharmacological role of the THC-cannabinoid phenolic moiety.

  1990cited by this paper
• Pharmacological evaluation of water soluble cannabinoids and related analogs.

  1990cited by this paper
• Cannabinoid receptor localization in brain.

  1990cited by this paper
• Structure of a cannabinoid receptor and functional expression of the cloned cDNA

  1990cited by this paper
• The molecular basis of cannabinoid activity.

  1990cited by this paper
• Investigation of the role of the phenolic hydroxyl in cannabinoid activity.

  1990cited by this paper
• Cannabimimetic activity of novel enantiomeric, benzofuran cannabinoids.

  1990cited by this paper
• High‐Affinity Cannabinoid Binding Site: Regulation by Ions, Ascorbic Acid, and Nucleotides

  1989cited by this paper
• The importance of the orientation of the C9 substituent to cannabinoid activity.

  1989cited by this paper
• The conformational analysis of delta 9- and delta 9,11-tetrahydrocannabinols in solution using high resolution nuclear magnetic resonance spectroscopy.

  1989cited by this paper
• Stereochemical effects of 11-OH-delta 8-THC-dimethylheptyl in mice and dogs.

  1989cited by this paper
• Pharmacology and stereoselectivity of structurally novel cannabinoids in mice.

  1988cited by this paper
• Nonclassical cannabinoid analgetics inhibit adenylate cyclase: development of a cannabinoid receptor model.

  1988cited by this paper
• Enantiomeric cannabinoids: stereospecificity of psychotropic activity

  1988cited by this paper
• Determination and characterization of a cannabinoid receptor in rat brain.

  1988cited by this paper
• Structure-activity relationships in cannabinoids.

  1986cited by this paper
• Health aspects of cannabis.

  1986cited by this paper
• High-affinity cannabinoid binding sites in brain membranes labeled with [3H]-5'-trimethylammonium delta 8-tetrahydrocannabinol.

  1985cited by this paper
• Pharmacological potency of R- and S-3'-hydroxy-delta 9-tetrahydrocannabinol: additional structural requirement for cannabinoid activity.

  1984cited by this paper
• A cannabinoid derived prototypical analgesic.

  1984cited by this paper
• 9-Nor-9-hydroxyhexahydrocannabinols. Synthesis, Some behavioral and analgesic properties, and comparison with the tetrahydrocannabinols.

  1976cited by this paper
• Hashish. Importance of the phenolic hydroxyl group in tetrahydrocannabinols.

  1975cited by this paper
• Marihuana-like activity of new synthetic tetrahydrocannabinols.

  1975cited by this paper
• Structure-activity relationships in the tetrahydrocannabinol series. Modifications on the aromatic ring and it the side-chain.

  1972cited by this paper
• Water-Soluble Derivatives of Δ1 Tetrahydrocannabinol

  1972cited by this paper
• Chemical Basis of Hashish Activity

  1970cited by this paper
• Tetrahydrocannabinol homologs.

  1948cited by this paper
• Tetrahydrocannabinol homologs with double branched alkyl groups in the 3-position.

  1948cited by this paper

• Syntheses of Cannabinoid Metabolites: Ajulemic Acid and HU-210

  2024cites this paper
• Modern Approaches to the Development of Synthetic Cannabinoid Receptor Probes.

  2021cites this paper
• The Structure–Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation

  2016cites this paper
• One-pot heterogeneous synthesis of Δ(3)-tetrahydrocannabinol analogues and xanthenes showing differential binding to CB(1) and CB(2) receptors.

  2014cites this paper
• 1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor.

  2014cites this paper
• Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.

  2013cites this paper
• Designer drugs: a medicinal chemistry perspective

  2012cites this paper
• [Cannabinoid drugs for neurological diseases: what is behind?].

  2012cites this paper
• Fármacos cannabinoides para las enfermedades neurológicas: ¿qué hay detrás?

  2012cites this paper
• Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: steric and electronic effects of 4- and 8-halogenated naphthoyl substituents.

  2012cites this paper
• High-performance sport, marijuana, and cannabimimetics.

  2011cites this paper
• Synthesis of novel cannabinoid ligands and their use as anti-glioma and anti-inflammatory agents

  2010cites this paper
• Antinociceptive activity of Delta9-tetrahydrocannabinol non-ionic microemulsions.

  2010cites this paper
• Design and synthesis of novel tri-aryl CB2 selective cannabinoid ligands.

  2009cites this paper
• Targeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 selective ligands

  2008cites this paper
• QSAR study of the structural and conformational requirements for the binding of anandamide analogs to the cannabinoid receptor CB1

  2008cites this paper
• Targeting cannabinoid agonists for inflammatory and neuropathic pain

  2007cites this paper
• Biochemical and mass spectrometric characterization of the human CB2 cannabinoid receptor expressed in Pichia pastoris--importance of correct processing of the N-terminus.

  2007cites this paper
• Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration.

  2007cites this paper
• 3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data.

  2006cites this paper
• The effects of charge‐neutralizing mutation D6.30N on the functions of CB1 and CB2 cannabinoid receptors

  2006cites this paper
• Recent progress in cannabinoid research.

  2006cites this paper
• The use of Natural Products as Sources of New Analgesic Drugs

  2005cites this paper
• CB2 receptor ligands.

  2005cites this paper
• Recent developments in the medicinal chemistry of cannabimimetic indoles, pyrroles and indenes.

  2005cites this paper
• Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.

  2005cites this paper
• Tricyclic pyrazoles. Part 2: Synthesis and biological evaluation of novel 4,5-dihydro-1H-benzo[g]indazole-based ligands for cannabinoid receptors.

  2005cites this paper
• Theoretical analysis of the NMR and electronic structure of novel Δ8-THC derivatives

  2004cites this paper
• 3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor.

  2003cites this paper
• Synthesis and testing of novel phenyl substituted side-chain analogues of classical cannabinoids.

  2003cites this paper
• Structure-activity relationships for 1',1'-dimethylalkyl-Delta8-tetrahydrocannabinols.

  2003cites this paper
• Synthesis and testing of novel classical cannabinoids: exploring the side chain ligand binding pocket of the CB1 and CB2 receptors.

  2003cites this paper
• Tricyclic pyrazoles. Part 1: synthesis and biological evaluation of novel 1,4-dihydroindeno[1,2-c]pyrazol-based ligands for CB1and CB2 cannabinoid receptors.

  2003cites this paper
• Structure–activity relationships for 1′,1′-dimethylalkyl-Δ 8 -tetrahydrocannabinols

  2003cites this paper
• Structure-Activity Relationships Investigation in a Mixed Series of Cannabinoids

  2002cites this paper
• Cannabis ( Marijuana ) — Effects on Human Behavior and Performance

  2002cites this paper
• Cannabinoid receptors and pain.

  2001cites this paper
• A pyridone analogue of traditional cannabinoids. A new class of selective ligands for the CB(2) receptor.

  2001cites this paper
• Δ9‐Tetrahydrocannabinol increases nerve growth factor production by prostate PC‐3 cells

  2001cites this paper
• delta(9)-Tetrahydrocannabinol increases nerve growth factor production by prostate PC-3 cells. Involvement of CB1 cannabinoid receptor and Raf-1.

  2001cites this paper
• Naturally occurring antinociceptive substances from plants

  2000cites this paper
• ntinociceptive activity of 9-tetrahydrocannabinol non-ionic microemulsions

  year unknowncites this paper