Photonic Crystal Optical Tweezers with High Efficiency for Live Biological Samples and Viability Characterization

We propose and demonstrate a new optical trapping method for single cells that utilizes modulated light fields to trap a wide array of cell types, including mammalian, yeast and Escherichia coli cells, on the surface of a two-dimensional photonic crystal. This method is capable of reducing the required light intensity and thus minimizing the photothermal damage to living cells, thereby extending cell viability in optical trapping and cell manipulation applications. To this end, a thorough characterization of cell viability in optical trapping environments was performed. This study also demonstrates the technique using spatial light modulation in patterned manipulation of live cell arrays over a broad area.

• Publication year

  2016

• Venue

  Scientific Reports

• Publication date

  2016-01-27

• Fields of study

  Biology, Materials Science, Physics, Engineering, Medicine

• Identifiers
  DOI 10.1038/srep19924PMID 26814808PMCID 4728687
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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