Endothelium-Derived 5-Methoxytryptophan Is a Circulating Anti-Inflammatory Molecule That Blocks Systemic Inflammation.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Circulation Research

• Publication date

  2016-05-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCRESAHA.116.308559PMID 27151398
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Prostacyclin protects vascular integrity via PPAR/14-3-3 pathway.

  2015cited by this paper
• Peroxiredoxin 1 Promotes Pancreatic Cancer Cell Invasion by Modulating p38 MAPK Activity

  2015cited by this paper
• ADP-Ribosylation Factor 3 Mediates Cytidine-Phosphate-Guanosine Oligodeoxynucleotide-Induced Responses by Regulating Toll-Like Receptor 9 Trafficking

  2015cited by this paper
• 5-Methoxytryptophan-dependent protection of cardiomyocytes from heart ischemia reperfusion injury.

  2014cited by this paper
• Inhibition of AMP-activated protein kinase accentuates lipopolysaccharide-induced lung endothelial barrier dysfunction and lung injury in vivo.

  2013cited by this paper
• NF-κB control of T cell development

  2013cited by this paper
• Quiescent and Proliferative Fibroblasts Exhibit Differential p300 HAT Activation through Control of 5-Methoxytryptophan Production

  2013cited by this paper
• Inhibition of IKK&bgr; in Enterocytes Exacerbates Sepsis-Induced Intestinal Injury and Worsens Mortality

  2013cited by this paper
• Transcriptional control by NF-κB: elongation in focus.

  2013cited by this paper
• The noncanonical NF‐κB pathway

  2012cited by this paper
• Dissecting negative regulation of Toll-like receptor signaling.

  2012cited by this paper
• Sepsis, thrombosis and organ dysfunction.

  2012cited by this paper
• Control of cyclooxygenase-2 expression and tumorigenesis by endogenous 5-methoxytryptophan

  2012cited by this paper
• TLR 2 Induces Vascular Smooth Muscle Cell Migration Through cAMP Response Element−Binding Protein−Mediated Interleukin-6 Production

  2012cited by this paper
• Kynurenines in the CNS: recent advances and new questions

  2012cited by this paper
• Platelet-derived serotonin links vascular disease and tissue fibrosis

  2011cited by this paper
• Pivotal Role of ADP-ribosylation Factor 6 in Toll-like Receptor 9-mediated Immune Signaling*

  2011influential reference
• Toll-like receptors: linking inflammation to metabolism.

  2011cited by this paper
• Surviving sepsis: going beyond the guidelines

  2011cited by this paper
• The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice

  2010cited by this paper
• Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle.

  2010cited by this paper
• Kynurenine is an endothelium-derived relaxing factor produced during inflammation

  2010cited by this paper
• NF-kappaB and p38 MAPK inhibition improve survival in endotoxin shock and in a cecal ligation and puncture model of sepsis in combination with antibiotic therapy.

  2009cited by this paper
• Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer

  2009cited by this paper
• Harmful molecular mechanisms in sepsis

  2008cited by this paper
• Inflammation, endothelium, and coagulation in sepsis

  2008cited by this paper
• Involvement of Heat Shock Protein (Hsp)90β but Not Hsp90α in Antiapoptotic Effect of CpG-B Oligodeoxynucleotide1

  2007cited by this paper
• High Macrophage Migration Inhibitory Factor Levels in Disseminated Intravascular Coagulation Patients with Systemic Inflammation

  2007cited by this paper
• Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide.

  2007cited by this paper
• MAPK p38 Regulates Transcriptional Activity of NF-κB in Primary Human Astrocytes via Acetylation of p651

  2007cited by this paper
• Endothelial function and dysfunction: testing and clinical relevance.

  2007cited by this paper
• Conditional Knockout Mice Reveal Distinct Functions for the Global Transcriptional Coactivators CBP and p300 in T-Cell Development

  2006cited by this paper
• Leukocyte apoptosis and its significance in sepsis and shock

  2005cited by this paper
• Model organisms: Animal Models of sepsis: setting the stage

  2005cited by this paper
• Transcriptional Control of COX-2 via C/EBP&bgr;

  2005cited by this paper
• A unique central tryptophan hydroxylase isoform.

  2003cited by this paper
• Up-regulation of p300 Binding and p50 Acetylation in Tumor Necrosis Factor-α-induced Cyclooxygenase-2 Promoter Activation*

  2003cited by this paper
• Novel strategies for the treatment of sepsis

  2003cited by this paper
• 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

  2003cited by this paper
• Transcriptional activation of the NF‐κB p65 subunit by mitogen‐ and stress‐activated protein kinase‐1 (MSK1)

  2003cited by this paper
• 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

  2003influential reference
• Regulation of Inducible Nitric Oxide Synthase Expression by p300 and p50 Acetylation 1

  2003cited by this paper
• Tryptophan and the immune response

  2003cited by this paper
• Obligatory Role of Cyclic Adenosine Monophosphate Response Element in Cyclooxygenase-2 Promoter Induction and Feedback Regulation by Inflammatory Mediators

  2002cited by this paper
• CREB-binding Protein and p300 in Transcriptional Regulation*

  2001cited by this paper
• Transcriptional Activation of the Cyclooxygenase-2 Gene in Endotoxin-treated RAW 264.7 Macrophages*

  2000cited by this paper
• NF-IL6 and NF-kappa B in cytokine gene regulation.

  1997cited by this paper

• Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases

  2026cites this paper
• Untargeted metabolomics profiling of childhood asthma: linking metabolic pattern to disease severity

  2026cites this paper
• Amino Acid Regulation in Metabolic Heart Disease: Mechanisms and Therapeutic Potential

  2026cites this paper
• The effect of 5MTP on the expression of inflammatory markers in human aortic endothelial cell.

  2026cites this paper
• The role of pulmonary vascular endothelial cell injury in COPD and its targeted therapeutic strategies

  2025cites this paper
• Impacts of aging and fluid shear stress on vascular endothelial metabolism and atherosclerosis development

  2025cites this paper
• Smooth muscle-specific expression of hydroxyindole O-methyltransferase reduces arterial injury-induced intimal hyperplasia

  2025influential citation
• Untargeted Metabolomic Analysis Using UPLC–MS/MS Reveals Metabolic Changes Associated With Lanmaoa asiatica Poisoning

  2025cites this paper
• Predictive Value of 5-Methoxytryptophan on Clinical Outcome in Patients with Sepsis Associated Acute Kidney Injury

  2025cites this paper
• ACE2 shedding exacerbates sepsis-induced gut leak via loss of microbial metabolite 5-methoxytryptophan

  2025influential citation
• 5-Methoxytryptophan Protects against Toll-Like Receptor 2-Mediated Renal Tissue Inflammation and Fibrosis in a Murine Unilateral Ureteral Obstruction Model

  2025influential citation
• Tracing NAD+ metabolism uncovers adaptive coordination between host and microbiome during colitis

  2025cites this paper
• Lung-gut axis, intestinal microbiota, and pulmonary fibrosis: mechanisms and therapeutic potential

  2025cites this paper
• Air Quality of Health Facilities in Spain.

  2024cites this paper
• Tryptophan, an important link in regulating the complex network of skin immunology response in atopic dermatitis

  2024cites this paper
• Roles of gut microbiome-associated metabolites in pulmonary fibrosis by integrated analysis

  2024cites this paper
• 5-Methoxytryptophan Alleviates Lipopolysaccharide-Induced Acute Kidney Injury by Regulating Nrf2-Mediated Mitophagy

  2024influential citation
• Control of inflammatory lung injury and repair by metabolic signaling in endothelial cells

  2024influential citation
• Identification of serum biomarkers for chronic kidney disease using serum metabolomics

  2024cites this paper
• Anti-inflammatory potential of aspergillus unguis SP51-EGY: TLR4-dependent effects & chemical diversity via Q-TOF LC-HRMS

  2024influential citation
• Inflammation and Prediction of Death in Type 2 Diabetes. Evidence of an Intertwined Link With Tryptophan Metabolism

  2024cites this paper
• Supplementation with Bifidobacterium animalis subsp. lactis MH-022 for remission of motor impairments in a 6-OHDA-induced Parkinson's disease rat model by reducing inflammation, reshaping the gut microbiome, and fostering specific microbial taxa.

  2024cites this paper
• 5-Methoxytryptophan Alleviates Dextran Sulfate Sodium-Induced Colitis by Inhibiting the Intestinal Epithelial Damage and Inflammatory Response

  2024influential citation
• New Insights into a Novel Metabolic Biomarker and Therapeutic Target for Chronic Kidney Disease

  2024cites this paper
• Tongxinluo capsule as a multi-functional traditional Chinese medicine in treating cardiovascular disease: A review of components, pharmacological mechanisms, and clinical applications

  2024cites this paper
• Predictive Value of 5-Methoxytryptophan on Long-Term Clinical Outcome after PCI in Patients with Acute Myocardial Infarction-a Prospective Cohort Study

  2024cites this paper
• Engineered antibody cytokine chimera synergizes with DNA-launched nanoparticle vaccines to potentiate melanoma suppression in vivo

  2023cites this paper
• Plasma Serotonin and Cardiovascular Outcomes in Chronic Kidney Disease

  2023cites this paper
• 5-Methoxytryptophan alleviates atrial structural remodeling in ibrutinib-associated atrial fibrillation

  2023cites this paper
• Metabolomics analysis of visceral leishmaniasis based on urine of golden hamsters

  2023cites this paper
• 5-Methoxytryptophan ameliorates endotoxin-induced acute lung injury in vivo and in vitro by inhibiting NLRP3 inflammasome-mediated pyroptosis through the Nrf2/HO-1 signaling pathway

  2023cites this paper
• High-fat diet alters the radiation tolerance of female mice and the modulatory effect of melatonin.

  2023cites this paper
• Endothelial cell metabolism in sepsis.

  2023cites this paper
• Circulating Metabolites Associate with and Improve the Prediction of All-Cause Mortality in Type 2 Diabetes.

  2022cites this paper
• Endothelial Damage in Sepsis: The Importance of Systems Biology

  2022cites this paper
• 5-Methoxytryptophan pretreatment alleviates lipopolysaccharide-induced cardiac injury and dysfunction

  2022cites this paper
• Mitochondrial interaction of fibrosis-protective 5-methoxy tryptophan enhances collagen uptake by macrophages

  2022influential citation
• Promising Strategies for Preserving Adult Endothelium Health and Reversing Its Dysfunction: From Liquid Biopsy to New Omics Technologies and Noninvasive Circulating Biomarkers

  2022cites this paper
• Gut microbiome and metabolites: The potential key roles in pulmonary fibrosis

  2022cites this paper
• Endothelium-dependent remote signaling in ischemia and reperfusion: alterations in the cardiometabolic continuum.

  2021cites this paper
• Tryptophan Metabolism and Cancer Progression

  2021influential citation
• Restoration of 5-methoxytryptophan protects against atherosclerotic chondrogenesis and calcification in ApoE−/− mice fed high fat diet

  2021cites this paper
• Association of Tumor Hydroxyindole O-Methyltransferase and Serum 5-Methoxytryptophan with Long-Term Survival of Hepatocellular Carcinoma

  2021cites this paper
• Control of Mesenchymal Stromal Cell Senescence by Tryptophan Metabolites

  2021cites this paper
• Control of Tissue Fibrosis by 5-Methoxytryptophan, an Innate Anti-Inflammatory Metabolite

  2021influential citation
• The Metabolic Mechanism Underlying the Enhancing Effects of Glycine and Tryptophan on Kidney Function: How to Reduce EGFR Inhibitory Effect on AAs

  2021cites this paper
• 5-Methoxytryptophan attenuates postinfarct cardiac injury by controlling oxidative stress and immune activation.

  2021cites this paper
• Cytoguardin: A Tryptophan Metabolite against Cancer Growth and Metastasis

  2021influential citation
• 5-methoxytryptophan alleviates liver fibrosis by modulating FOXO3a/miR-21/ATG5 signaling pathway mediated autophagy

  2021cites this paper
• The role of 5-methoxytryptophan in pediatric-onset lupus nephritis: A retrospective cohort study.

  2020cites this paper
• Treatment with 5-methoxytryptophan attenuates microglia-induced neuroinflammation in spinal cord trauma.

  2020cites this paper
• Poricoic acid A as a modulator of TPH-1 expression inhibits renal fibrosis via modulating protein stability of β-catenin and β-catenin-mediated transcription

  2020cites this paper
• Endogenous tryptophan metabolite 5-Methoxytryptophan inhibits pulmonary fibrosis by downregulating the TGF-β/SMAD3 and PI3K/AKT signaling pathway.

  2020cites this paper
• Tryptophan decreases the intensity of lipopolysaccharide-induced acute lung injury in a rat model

  2020cites this paper
• 5-methoxytryptophan: an arsenal against vascular injury and inflammation

  2020cites this paper
• Longitudinal relationship of amino acids and indole metabolites with long-term body mass index and cardiometabolic risk markers in young individuals

  2020cites this paper
• TLR2 Promotes Vascular Smooth Muscle Cell Chondrogenic Differentiation and Consequent Calcification via the Concerted Actions of Osteoprotegerin Suppression and IL-6–Mediated RANKL Induction

  2019cites this paper
• Diastereoselective synthesis of 3,4-dihydropyran-3-carboxamides with in vitro anti-inflammatory activity.

  2019cites this paper
• Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan

  2019cites this paper
• Persistent elevation of blood pressure by ambient coarse particulate matter after recovery from pulmonary inflammation in mice

  2019cites this paper
• Vanadium Derivative Exposure Promotes Functional Alterations of VSMCs and Consequent Atherosclerosis via ROS/p38/NF-κB-Mediated IL-6 Production

  2019cites this paper
• Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor.

  2019cites this paper
• Tryptophan metabolite 5-methoxytryptophan ameliorates arterial denudation-induced intimal hyperplasia via opposing effects on vascular endothelial and smooth muscle cells

  2019cites this paper
• Restoration of hydroxyindole O-methyltransferase levels in human cancer cells induces a tryptophan-metabolic switch and attenuates cancer progression

  2018influential citation
• Metabolic systems analysis of LPS induced endothelial dysfunction applied to sepsis patient stratification

  2018cites this paper
• The determination of 5-methoxytryptophan in human plasma.

  2018cites this paper
• 5-methoxytryptophan protects MSCs from stress induced premature senescence by upregulating FoxO3a and mTOR

  2017cites this paper
• Simvastatin Ameliorates PAK4 Inhibitor-Induced Gut and Lung Injury

  2017cites this paper
• 5-Methoxytryptophan: A promising early marker for predicting post-myocardial infarction heart failure.

  2017cites this paper
• Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases

  2017cites this paper
• Intranasal post-cardiac arrest treatment with orexin-A facilitates arousal from coma and ameliorates neuroinflammation

  2017cites this paper
• Reply to letter: "5-Methoxytryptophan: A promising early marker for predicting post-myocardial infarction heart failure".

  2017cites this paper
• New Member of Endothelial Arsenal Against Inflammation.

  2016cites this paper
• TLR4-Activated MAPK-IL-6 Axis Regulates Vascular Smooth Muscle Cell Function

  2016cites this paper
• Angiotensin II-Induced Early and Late Inflammatory Responses Through NOXs and MAPK Pathways

  2016cites this paper
• Myofibroblasts and inflammatory cells as players of cardiac fibrosis

  2016cites this paper
• Myofibroblasts and inflammatory cells as players of cardiac fibrosis

  2016cites this paper
• Circulation Research "In This Issue" Anthology.

  2012cites this paper
• World Journal of Gastroenterology

  year unknowncites this paper