Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Arthritis & Rheumatism

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 17968906
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Correction: Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis

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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  1998cited by this paper
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  1988cited by this paper
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  1986cited by this paper
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  1984cited by this paper
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  1977cited by this paper
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  1977cited by this paper
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  1975cited by this paper
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  1973cited by this paper

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