Evaluation of thyroid function abnormalities in sixty dogs naturally infected with Babesia canis

Canine babesiosis is world-wide tick-borne disease characterized by erythrocyte destruction, haemolysis and inflammatory response, with increased serum concentrations of positive acute phase proteins and a decrease in negative acute phase proteins. Some of the negative acute phase proteins function as carriers of thyroid hormones, so the goal of this study was to determine the non-thyroidal illness syndrome in dogs with babesiosis. The study included 60 dogs with babesiosis and 26 healthy dogs. Serum concentrations of thyroxine, thyrotropin and transthyretin were determined using ELISA methods, while albumin concentrations were measured using spectrophotometric methods. Statistical analysis of the data demonstrated a significant decrease in thyroxine, transthyretin and albumin in dogs with babesiosis, while thyrotropin concentrations were did not differ significantly in comparison with healthy dogs. The results obtained indicate the presence of a non-thyroidal illness. Decreased albumin and transthyretin probably represent one of the mechanisms which contribute to this syndrome in canine babesiosis.

• Publication year

  2019

• Venue

  Veterinarski arhiv (Tisak)

• Publication date

  2019-02-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.24099/VET.ARHIV.0543
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Euthyroid Sick Syndrome

  2019cited by this paper
• Low T3 syndrome in canine babesiosis associated with increased serum IL-6 concentration and azotaemia.

  2015cited by this paper
• Serum transthyretin concentration is decreased in dogs with nonthyroidal illness.

  2012cited by this paper
• IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cells.

  2011cited by this paper
• Babesiosis in dogs and cats--expanding parasitological and clinical spectra.

  2011cited by this paper
• Electrophoretic profile of serum protein fractions from sheep naturally infected with Babesia ovis

  2010cited by this paper
• Mechanisms behind the non-thyroidal illness syndrome: an update.

  2010influential reference
• Treating nonthyroidal illness syndrome in the critically ill patient: still a matter of controversy.

  2009cited by this paper
• Systemic inflammatory responses in dogs experimentally infected with Babesia canis; a haematological study.

  2009cited by this paper
• Diversity of Babesia and Theileria species in symptomatic and asymptomatic dogs in Croatia.

  2009cited by this paper
• Thyroid hormone therapy is not indicated in the majority of patients with the sick euthyroid syndrome.

  2008influential reference
• Endocrine predictors of mortality in canine babesiosis caused by Babesia canis rossi.

  2007cited by this paper
• Acute phase proteins in dogs and cats: current knowledge and future perspectives.

  2005cited by this paper
• Albumin in Health and Disease: Causes and Treatment of Hypoalbuminemia*

  2004cited by this paper
• Dissociation of the early decline in serum T(3) concentration and serum IL-6 rise and TNFalpha in nonthyroidal illness syndrome induced by abdominal surgery.

  2001cited by this paper
• A preliminary study on the serum protein response in canine babesiosis.

  2000cited by this paper
• Concordant decreases of thyroxine and thyroxine binding protein concentrations during sepsis.

  2000cited by this paper
• A characteristic serpin cleavage product of thyroxine-binding globulin appears in sepsis sera.

  2000cited by this paper
• Dangerous Dogmas in Medicine: The Nonthyroidal Illness Syndrome

  1999influential reference
• Effects of IL-10 on systemic inflammatory responses during sublethal primate endotoxemia.

  1997cited by this paper
• Continuous infusion of interleukin-1 beta induces a nonthyroidal illness syndrome in the rat.

  1992cited by this paper
• Canine and Feline Endocrinology and Reproduction

  1987influential reference
• Thyroxine therapy in patients with severe nonthyroidal illnesses and low serum thyroxine concentration.

  1986cited by this paper
• Thyroid hormone binding in serum of 15 vertebrate species: isolation of thyroxine-binding globulin and prealbumin analogs.

  1985cited by this paper
• [Thyroxine-binding serum proteins in the cat as compared to dog and man].

  1976cited by this paper
• A clinico-pathological study of Babesia canis infection in dogs

  1968cited by this paper
• Pathological processes in Babesia canis infections.

  1957cited by this paper

• Incidence, complications and therapeutic evaluation of clinical hypothyroidism in different breeds of dogs

  2025cites this paper
• Prevalence of canine babesiosis and their risk factors among asymptomatic dogs in the federal capital territory, Abuja, Nigeria

  2020cites this paper
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  2019cites this paper