Reduced computational modelling of Kölliker‐Fuse contributions to breathing patterns in Rett syndrome

Reduced computational models are used to test effects of loss of inhibition to the Kölliker‐Fuse nucleus (KFn). Three reduced computational models that simulate eupnoeic and vagotomized respiratory rhythms are considered. All models exhibit the emergence of respiratory perturbations associated with Rett syndrome as inhibition to the KFn is diminished. Simulations suggest that application of 5‐HT1A agonists can mitigate the respiratory pathology. The three models can be distinguished and tested based on their predictions about connections and dynamics within the respiratory circuit and about effects of perturbations on certain respiratory neuron populations.

• Publication year

  2019

• Venue

  Journal of Physiology

• Publication date

  2019-04-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1113/JP277592PMID 30908648PMCID PMC6826262
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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