The Importance of Being an Antagonist as Well as Persistent

The current work by Jain et al. (S. Jain, A. ABSTRACT The current work by Jain et al. (S. Jain, A. M. Chang, M. Singh, J. S. McLean, et al., J Bacteriol 201:e00683-18, 2019, https://doi.org/10.1128/JB.00683-18) reports the cloning of the lipid A deacylase gene of Porphyromonas gingivalis and the phenotypic characterization of the enzyme. Attempts to clone the gene and thus provide proof of the existence of this enzyme had gone on for 2 decades. The enzyme is central to the bacterium’s ability to modify and tailor the structure of its lipid A, changing a lipid A that is a moderate Toll-like receptor 4 (TLR4) agonist to an antagonist or silencer and thereby potentially changing the course of infection.

• Publication year

  2019

• Venue

  Journal of Bacteriology

• Publication date

  2019-03-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JB.00146-19PMID 30910810PMCID PMC6509661
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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