DUBLIN (Degree of Ulcerative colitis Burden of Luminal INflammation) score, a simple method to quantify inflammatory burden in Ulcerative Colitis.

BACKGROUND & AIMS Endoscopic scores of local severity do not reflect disease extent, or disease burden. The DUBLIN score is a simple bedside clinical score that estimates inflammatory burden using both disease severity and extent. As the need to personalise therapy for UC patients increases, a score to accurately assess disease burden will be of great relevance. The aim of this study was to assess the clinical utility of the DUBLIN score by comparing its performance with objective biomarkers. METHODS DUBLIN score was calculated as a product of Mayo Endoscopic Score (0-3) and disease extent (E1-E3). Correlation with objective biomarkers was performed in a retrospective 'discovery cohort'. A 'validation cohort was recruited from a single centre,where clinical outcomes, colectomy rate and biochemical data were collected prospectively. RESULTS The discovery cohort included 70 patients with UC. DUBLIN score correlated significantly with faecal calprotectin levels. (r= 0.394; p<0.01). ROC analysis using FCP>50μg/g showed a higher AUC with DUBLIN score (AUC=0.76) than Mayo Score (AUC 0.73). The validation cohort included 41 patients. Patients with high inflammatory burden (DUBLIN >3) had higher C-reactive protein and faecal calprotectin, and lower albumin than low inflammtory burden patients. High DUBLIN score was associated with an increased risk of treatment failure. (HR 2.98 95% CI 1.002-8.87; p=0.049). CONCLUSION The DUBLIN score is a simple measure of inflammatory burden which correlates with objective inflammatory markers and is associated with clinical outcomes such treatment failure. DUBLIN score has the potential to assist in personalising therapy for patients with UC.

• Publication year

  2019

• Venue

  Journal of Crohn's & Colitis

• Publication date

  2019-10-28

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/ECCO-JCC/JJZ067PMID 30911757
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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