Cartilage biomechanics: A key factor for osteoarthritis regenerative medicine.

Osteoarthritis (OA) is a joint disorder that is highly extended in the global population. Several researches and therapeutic strategies have been probed on OA but without satisfactory long-term results in joint replacement. Recent evidences show how the cartilage biomechanics plays a crucial role in tissue development. This review describes how physics alters cartilage and its extracellular matrix (ECM); and its role in OA development. The ECM of the articular cartilage (AC) is widely involved in cartilage turnover processes being crucial in regeneration and joint diseases. We also review the importance of physicochemical pathways following the external forces in AC. Moreover, new techniques probed in cartilage tissue engineering for biomechanical stimulation are reviewed. The final objective of these novel approaches is to create a cellular implant that maintains all the biochemical and biomechanical properties of the original tissue for long-term replacements in patients with OA.

• Publication year

  2019

• Venue

  Biochimica et Biophysica Acta - Molecular Basis of Disease

• Publication date

  2019-06-01

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1016/j.bbadis.2019.03.011PMID 30910703
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Biomaterials for articular cartilage tissue engineering: Learning from biology.

  2018cited by this paper
• Characteristics, applications and prospects of mesenchymal stem cells in cell therapy.

  2017cited by this paper
• Chondrocyte primary cilium is mechanosensitive and responds to low-intensity-ultrasound by altering its length and orientation.

  2017cited by this paper
• Osteoarthritis year in review 2016: mechanics.

  2017cited by this paper
• Low-intensity pulsed ultrasound (LIPUS) treatment of cultured chondrocytes stimulates production of CCN family protein 2 (CCN2), a protein involved in the regeneration of articular cartilage: mechanism underlying this stimulation.

  2017cited by this paper
• Collective cell durotaxis emerges from long-range intercellular force transmission

  2016cited by this paper
• Chondro-protective effects of low intensity pulsed ultrasound.

  2016cited by this paper
• Articular cartilage: from formation to tissue engineering.

  2016cited by this paper
• Interstitial Perfusion Culture with Specific Soluble Factors Inhibits Type I Collagen Production from Human Osteoarthritic Chondrocytes in Clinical-Grade Collagen Sponges

  2016cited by this paper
• Multiscale musculoskeletal modelling, data–model fusion and electromyography-informed modelling

  2016cited by this paper
• The Potential Application of Pulsed Ultrasound on Bone Defect Repair via Developmental Engineering: An In Vitro Study.

  2016cited by this paper
• Improved Human Bone Marrow Mesenchymal Stem Cell Osteogenesis in 3D Bioprinted Tissue Scaffolds with Low Intensity Pulsed Ultrasound Stimulation

  2016cited by this paper
• Low-Intensity Pulsed Ultrasound Affects Chondrocyte Extracellular Matrix Production via an Integrin-Mediated p38 MAPK Signaling Pathway.

  2015cited by this paper
• Repair and tissue engineering techniques for articular cartilage

  2015cited by this paper
• Effects of low-intensity pulsed ultrasound on integrin-FAK-PI3K/Akt mechanochemical transduction in rabbit osteoarthritis chondrocytes.

  2014cited by this paper
• An analytical model to predict interstitial lubrication of cartilage in migrating contact areas.

  2014cited by this paper
• The individual and socioeconomic impact of osteoarthritis

  2014cited by this paper
• TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading

  2014cited by this paper
• The role of aggrecan in normal and osteoarthritic cartilage

  2014cited by this paper
• In the clinic. Osteoarthritis.

  2014cited by this paper
• Chondrogenic Phenotype of Articular Chondrocytes in Monoculture and Co-Culture with Mesenchymal Stem Cells in Flow Perfusion

  2014cited by this paper
• Mechanical loading stimulates chondrogenesis via the PKA/CREB-Sox9 and PP2A pathways in chicken micromass cultures.

  2014cited by this paper
• Strain-induced Differentiation of Fetal Type II Epithelial Cells Is Mediated via the Integrin α6β1-ADAM17/Tumor Necrosis Factor-α-converting Enzyme (TACE) Signaling Pathway*

  2013cited by this paper
• Roles of cadherins and catenins in cell-cell adhesion and epithelial cell polarity.

  2013cited by this paper
• Integrins in mechanotransduction.

  2013cited by this paper
• Promotion of Ccn2 expression and osteoblastic differentiation by actin polymerization, which is induced by laminar fluid flow stress

  2012cited by this paper
• The role of synovitis in osteoarthritis pathogenesis.

  2012cited by this paper
• Integrin-mediated mechanotransduction pathway of low-intensity continuous ultrasound in human chondrocytes.

  2012cited by this paper
• Primary cilia elongation in response to interleukin-1 mediates the inflammatory response

  2012cited by this paper
• Chondrocyte primary cilia shorten in response to osmotic challenge and are sites for endocytosis.

  2012cited by this paper
• Inflammation in Atherosclerosis

  2012cited by this paper
• Primary cilia mediate mechanotransduction through control of ATP‐induced Ca2+ signaling in compressed chondrocytes

  2012cited by this paper
• The primary cilium as a dual sensor of mechanochemical signals in chondrocytes

  2012cited by this paper
• Strategies for Enhancing the Accumulation and Retention of Extracellular Matrix in Tissue-Engineered Cartilage Cultured in Bioreactors

  2011cited by this paper
• Bone tissue engineering bioreactors: dynamic culture and the influence of shear stress.

  2011cited by this paper
• Cell Mechanics and Cellular Engineering

  2011cited by this paper
• Orientation of Primary Cilia of Articular Chondrocytes in Three‐Dimensional Space

  2011cited by this paper
• Articular chondrocytes express connexin 43 hemichannels and P2 receptors – a putative mechanoreceptor complex involving the primary cilium?

  2009cited by this paper
• Hydrostatic Pressure in Articular Cartilage Tissue Engineering: From Chondrocytes to Tissue Regeneration

  2009cited by this paper
• The Transcriptional Activity of Sox9 in Chondrocytes Is Regulated by RhoA Signaling and Actin Polymerization

  2009cited by this paper
• Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes.

  2009cited by this paper
• SOX9 Directly Binds CREB as a Novel Synergism With the PKA Pathway in BMP‐2–Induced Osteochondrogenic Differentiation

  2009cited by this paper
• Hydrostatic Pressure Enhances Chondrogenic Differentiation of Human Bone Marrow Stromal Cells in Osteochondrogenic Medium

  2008cited by this paper
• Low-intensity pulsed ultrasound affects human articular chondrocytes in vitro

  2008cited by this paper
• Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I.

  2008cited by this paper
• Synergistic and Additive Effects of Hydrostatic Pressure and Growth Factors on Tissue Formation

  2008cited by this paper
• Effects of Temporal Hydrostatic Pressure on Tissue-Engineered Bovine Articular Cartilage Constructs

  2008cited by this paper
• Browser’s notes

  2008cited by this paper
• Low-intensity pulsed ultrasound stimulates osteogenic differentiation in ROS 17/2.8 cells.

  2007cited by this paper
• Light and low-frequency pulsatile hydrostatic pressure enhances extracellular matrix formation by bone marrow mesenchymal cells: an in-vitro study with special reference to cartilage repair.

  2007cited by this paper
• Cartilage tissue engineering and bioreactor systems for the cultivation and stimulation of chondrocytes

  2007cited by this paper
• Analysis and Quantitation of NF-κB Nuclear Translocation in Tumor Necrosis Factor Alpha (TNF-α) Activated Vascular Endothelial Cells

  2006cited by this paper
• Clinical practice. Osteoarthritis of the knee.

  2006cited by this paper
• A review on the mechanical quality of articular cartilage - implications for the diagnosis of osteoarthritis.

  2006cited by this paper
• Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression

  2005cited by this paper
• Cyclic hydrostatic compression stimulates chondroinduction of C3H/10T1/2 cells

  2005cited by this paper
• A novel method for assessing effects of hydrostatic fluid pressure on intracellular calcium: a study with bovine articular chondrocytes.

  2005cited by this paper
• Ultrasound Enhances Transforming Growth Factor β-Mediated Chondrocyte Differentiation of Human Mesenchymal Stem Cells

  2004cited by this paper
• The surface of articular cartilage contains a progenitor cell population

  2004cited by this paper
• Intermittent hydrostatic pressure inhibits matrix metalloproteinase and pro-inflammatory mediator release from human osteoarthritic chondrocytes in vitro.

  2004cited by this paper
• Structure and Function of Articular Cartilage

  2003cited by this paper
• The pathophysiology of osteoarthritis

  2003cited by this paper
• Cartilage interstitial fluid load support in unconfined compression.

  2003cited by this paper
• Inflammation in atherosclerosis

  2002cited by this paper
• Perfusion Increases Cell Content and Matrix Synthesis in Chondrocyte Three-Dimensional Cultures

  2002cited by this paper
• The effects of osmotic and hydrostatic pressures on macromolecular systems.

  2002cited by this paper
• Low‐Intensity Pulsed Ultrasound Accelerates Rat Femoral Fracture Healing by Acting on the Various Cellular Reactions in the Fracture Callus

  2001cited by this paper
• Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways.

  2001cited by this paper
• Mechanical control of cyclic AMP signalling and gene transcription through integrins

  2000cited by this paper
• Protein Kinase A Regulates Chondrogenesis of Mesenchymal Cells at the Post‐Precartilage Condensation Stage via Protein Kinase C‐α Signaling

  2000cited by this paper
• The role of microtubules in the regulation of proteoglycan synthesis in chondrocytes under hydrostatic pressure.

  2000cited by this paper
• Comparison of Chondrogensis in Static and Perfused Bioreactor Culture

  2000cited by this paper
• Cloning and Characterization of ADAMTS11, an Aggrecanase from the ADAMTS Family*

  1999cited by this paper
• Human chondrocyte culture models for studying cyclooxygenase expression and prostaglandin regulation of collagen gene expression.

  1999cited by this paper
• The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models.

  1999cited by this paper
• Intermittent sub-ambient interstitial hydrostatic pressure as a potential mechanical stimulator for chondrocyte metabolism.

  1999cited by this paper
• Modulation of Na+ x H+ exchange by hydrostatic pressure in isolated bovine articular chondrocytes.

  1999cited by this paper
• Articular cartilage: tissue design and chondrocyte-matrix interactions.

  1998cited by this paper
• Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation.

  1998cited by this paper
• Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition.

  1998cited by this paper
• Pathophysiology of osteoarthritis.

  1998cited by this paper
• Articular cartilage: injuries and potential for healing.

  1998cited by this paper
• Signal Transduction of Mechanical Stimuli Is Dependent on Microfilament Integrity: Identification of Osteopontin as a Mechanically Induced Gene in Osteoblasts

  1997cited by this paper
• Phenotypic modulation of chondrocytes as a potential therapeutic target in osteoarthritis: a hypothesis

  1997cited by this paper
• In vitro stimulation of articular chondrocyte mRNA and extracellular matrix synthesis by hydrostatic pressure

  1996cited by this paper
• Effects of cyclic hydrostatic pressure on proteoglycan synthesis in cultured chondrocytes and articular cartilage explants.

  1993cited by this paper
• Mechanical determinants of osteoarthrosis.

  1991cited by this paper
• Cartilage collagens. What is their function, and are they involved in articular disease?

  1989cited by this paper
• Alterations in chondrocyte cytoskeletal architecture during phenotypic modulation by retinoic acid and dihydrocytochalasin B-induced reexpression

  1988cited by this paper
• Energy‐speed relationship of walking: Standard tables

  1988cited by this paper
• Contact pressures in the human hip joint.

  1987cited by this paper
• The Etiology of Osteoarthritis of the Hip

  1986cited by this paper
• Contact pressures in the human hip joint measured in vivo.

  1986cited by this paper
• An analysis of the unconfined compression of articular cartilage.

  1984cited by this paper
• Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels.

  1982cited by this paper
• Biphasic creep and stress relaxation of articular cartilage in compression? Theory and experiments.

  1980cited by this paper
• Arthritis and Allied Conditions: A Textbook of Rheumatology

  1973cited by this paper

• Nutritional Interventions in Osteoarthritis: Mechanisms, Clinical Evidence, and Translational Opportunities

  2026cites this paper
• Injectable thermosensitive methylcellulose–carboxymethyl chitosan hydrogel for the delivery of human amniotic fluid mesenchymal stromal cell spheroids in cartilage regeneration

  2025cites this paper
• Harnessing the dual immunomodulatory function of myeloid-derived suppressor cells to reshape the inflammatory microenvironment for osteoarthritis therapy

  2025cites this paper
• Tracking in vitro biodegradation dynamics in cartilage tissue engineering using dual-labeled hydrogel/scaffold composites

  2025cites this paper
• Amniotic fluid MSCs for scaffold-free cartilage repair: spheroid fusion and chondrogenic microtissue development

  2025cites this paper
• Fibrocartilage hyalinization: A potential therapeutic strategy for articular fibrocartilage

  2025cites this paper
• MMP13 mRNA Expression Level as a Potential Marker for Knee OA Progression—An Observational Study

  2025cites this paper
• Optimization of the Mechanical Properties of PVA/Gelatin Hydrogel Reinforced with Polycaprolactone Nanofibers Using the Finite Element Method

  2025cites this paper
• Oxymatrine protects articular chondrocytes from IL-1β-induced damage through autophagy activation via AKT/mTOR signaling pathway inhibition

  2024cites this paper
• Association between niacin intake and knee osteoarthritis pain and function: a longitudinal cohort study

  2024cites this paper
• Low-temperature Extrusion of Waterborne Polyurethane - Polycaprolactone Composites For Multi-Material Bio-Printing of Engineered Elastic Cartilage.

  2024cites this paper
• Loss-of-function of DDR1 is responsible for a chondrodysplasia with multiple dislocations.

  2024cites this paper
• Dehydroepiandrosterone inhibits ADAMTS expression via an ERK-dependent mechanism in chondrocytes

  2024cites this paper
• Delivery Strategies of Growth Factors in Cartilage Tissue Engineering

  2024cites this paper
• Morphologic Response in Femoral Cartilage During and After 40-Minute Treadmill Running.

  2024cites this paper
• Advancements and challenges in bionic joint lubrication biomaterials for sports medicine

  2024cites this paper
• Suppression of YAP Ameliorates Cartilage Degeneration in Ankle Osteoarthritis via Modulation of the Wnt/β-Catenin Signaling Pathway

  2024cites this paper
• Hypoxic Conditions Modulate Chondrogenesis through the Circadian Clock: The Role of Hypoxia-Inducible Factor-1α

  2024cites this paper
• Injectable hydrogels: An emerging therapeutic strategy for cartilage regeneration.

  2023cites this paper
• Smart Biomaterials for Articular Cartilage Repair and Regeneration

  2023cites this paper
• The Efficacy of Intra-articular Umbilical Cord-Mesenchymal Stem Cell Injection for Knee Osteoarthritis: a Systematic Review

  2023cites this paper
• Human Cartilage Biomechanics: Experimental and Theoretical Approaches towards the Identification of Mechanical Properties in Healthy and Osteoarthritic Conditions

  2023cites this paper
• Failure of cartilage regeneration: emerging hypotheses and related therapeutic strategies

  2023cites this paper
• The intricate mechanism of PLS3 in bone homeostasis and disease

  2023cites this paper
• Biomechanics of Chondrocytes and Chondrons in Healthy Conditions and Osteoarthritis: A Review of the Mechanical Characterisations at the Microscale

  2023cites this paper
• The Roles of the Hippo-YAP signalling pathway in Cartilage and Osteoarthritis.

  2023cites this paper
• An advanced biphasic porous and injectable scaffold displays a fine balance between mechanical strength and remodeling capabilities essential for cartilage regeneration.

  2023cites this paper
• Evaluation of the Effects of Halloysite Nanotubes on Physical, Mechanical, and Biological Properties of Polyhydroxy Butyrate Electrospun Scaffold for Cartilage Tissue Engineering Applications

  2023cites this paper
• IL-17 in osteoarthritis: A narrative review

  2023cites this paper
• Molecular Rotors: Fluorescent Sensors for Microviscosity and Conformation of Biomolecules

  2023cites this paper
• Global trends and hotspots in the application of platelet-rich plasma in knee osteoarthritis: A bibliometric analysis from 2008 to 2022

  2023cites this paper
• MiR-146b-5p enriched bioinspired exosomes derived from fucoidan-directed induction mesenchymal stem cells protect chondrocytes in osteoarthritis by targeting TRAF6

  2023cites this paper
• Location-Dependent Human Osteoarthritis Cartilage Response to Realistic Cyclic Loading: Ex-Vivo Analysis on Different Knee Compartments

  2022cites this paper
• Cartilage biomechanics: From the basic facts to the challenges of tissue engineering.

  2022cites this paper
• Time-dependent hyper-viscoelastic parameter identification of human articular cartilage and substitute materials.

  2022cites this paper
• Within or Without You? A Perspective Comparing In Situ and Ex Situ Tissue Engineering Strategies for Articular Cartilage Repair

  2022cites this paper
• Immunohistochemical evaluation of autotaxin and lubricin in mild osteoarthritic rat model performing moderate physical activity.

  2022cites this paper
• Chondro‐Inductive b‐TPUe‐Based Functionalized Scaffolds for Application in Cartilage Tissue Engineering

  2022cites this paper
• Autologous chondrocyte implantation provides good long-term clinical results in the treatment of knee osteoarthritis: a systematic review

  2022influential citation
• The strain-generated electrical potential in cartilaginous tissues: a role for piezoelectricity

  2021cites this paper
• Plastin 3 in health and disease: a matter of balance

  2021cites this paper
• Hard- and software development of a mechanobiological organ-on-a-chip platform

  2021cites this paper
• Mechanobiological Interactions between Dynamic Compressive Loading and Viscoelasticity on Chondrocytes in Hydrazone Covalent Adaptable Networks for Cartilage Tissue Engineering

  2021cites this paper
• Sprifermin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-Related Diseases

  2021cites this paper
• Biomechanics of Cartilage Repair

  2021cites this paper
• Recent Advances in Understanding the Role of Cartilage Lubrication in Osteoarthritis

  2021cites this paper
• Role and application of bone morphogenetic proteins in articular cartilage regeneration

  2021cites this paper
• Biomechanics of the Knee

  2021cites this paper
• Chondrodysplasias With Multiple Dislocations Caused by Defects in Glycosaminoglycan Synthesis

  2021cites this paper
• Phenolated alginate-collagen hydrogel induced chondrogenic capacity of human amniotic mesenchymal stem cells

  2021cites this paper
• Disorganization of chondrocyte columns in the growth plate does not aggravate experimental osteoarthritis in mice

  2020cites this paper
• Ozone induces autophagy by activating PPARγ/mTOR in rat chondrocytes treated with IL-1β

  2020cites this paper
• Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice

  2020cites this paper