Human Vascular Pericytes and Cytomegalovirus Pathobiology

Pericytes are multipotent cells of the vascular system with cytoplasmic extensions proximal to endothelial cells that occur along the abluminal surface of the endothelium. The interactions between endothelial cells and pericytes are essential for proper microvascular formation, development, stabilization, and maintenance. Pericytes are essential for the regulation of paracellular flow between cells, transendothelial fluid transport, angiogenesis, and vascular immunosurveillance. They also influence the chemical composition of the surrounding microenvironment to protect endothelial cells from potential harm. Dysregulation or loss of pericyte function can result in microvascular instability and pathological consequences. Human pericytes have been shown to be targets for human cytomegalovirus (HCMV) infection and lytic replication that likely contribute to vascular inflammation. This review focuses on human vascular pericytes and their permissiveness for HCMV infection. It also discusses their implication in pathogenesis in the blood–brain barrier (BBB), the inner blood–retinal barrier (IBRB), the placenta–blood barrier, and the renal glomerulus as well as their potential role in subclinical vascular disease.

• Publication year

  2019

• Venue

  International Journal of Molecular Sciences

• Publication date

  2019-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.3390/ijms20061456PMID 30909422PMCID 6471229
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pericyte Biology: Development, Homeostasis, and Disease.

  2018cited by this paper
• Magnetic Nanoparticles Interact and Pass an In Vitro Co-Culture Blood-Placenta Barrier Model †

  2018cited by this paper
• Role of pericytes in vascular immunosurveillance.

  2018cited by this paper
• Mesangial cells, specialized renal pericytes and cytomegalovirus infectivity: Implications for HCMV pathology in the glomerular vascular unit and post-transplant renal disease

  2018influential reference
• Placental pericytes and cytomegalovirus infectivity: Implications for HCMV placental pathology and congenital disease

  2017influential reference
• Cell biology of mesangial cells: the third cell that maintains the glomerular capillary

  2017cited by this paper
• Cytomegalovirus infection and atherosclerosis risk: A meta‐analysis

  2017cited by this paper
• Plastic roles of pericytes in the blood–retinal barrier

  2017cited by this paper
• Human cytomegalovirus infection and vascular disease risk: A meta-analysis.

  2017cited by this paper
• What is a pericyte?

  2016cited by this paper
• Evaluation of Infectious Complications in the First Year After Kidney Transplantation.

  2015cited by this paper
• Retinal pericytes and cytomegalovirus infectivity: implications for HCMV-induced retinopathy and congenital ocular disease

  2015influential reference
• Mechanisms of Vessel Pruning and Regression.

  2015cited by this paper
• Risk Factors of Cytomegalovirus Disease in Kidney Transplant Recipients: A Single-Center Study in Thailand.

  2015cited by this paper
• Long-term impact of CMV infection on allografts and on patient survival in renal transplant patients with protocol biopsies.

  2015cited by this paper
• Cytomegalovirus coinfection is associated with an increased risk of severe non-AIDS-defining events in a large cohort of HIV-infected patients.

  2015cited by this paper
• Mother-to-Child Transmission of Cytomegalovirus and Prevention of Congenital Infection.

  2014cited by this paper
• Emerging Cytomegalovirus Management Strategies After Solid Organ Transplantation: Challenges and Opportunities

  2014cited by this paper
• Pericyte Dynamics during Angiogenesis: New Insights from New Identities

  2014cited by this paper
• Intrauterine growth restriction caused by underlying congenital cytomegalovirus infection.

  2014cited by this paper
• Targeting Pericytes for Angiogenic Therapies

  2014cited by this paper
• Cytokine analysis of aqueous humor in HIV patients with cytomegalovirus retinitis.

  2013cited by this paper
• PRIMARY CYTOMEGALOVIRUS INFECTION DURING PREGNANCY.

  2012cited by this paper
• Human Cytomegalovirus-Induces Cytokine Changes in the Placenta with Implications for Adverse Pregnancy Outcomes

  2012cited by this paper
• Human Cytomegalovirus Linked to Stroke in a Chinese Population

  2012cited by this paper
• Macrophage Activation Associated with Chronic Murine Cytomegalovirus Infection Results in More Severe Experimental Choroidal Neovascularization

  2012influential reference
• Biology of the renal pericyte.

  2012cited by this paper
• Infection and upregulation of proinflammatory cytokines in human brain vascular pericytes by human cytomegalovirus

  2012influential reference
• Cytomegalovirus-induced immunopathology and its clinical consequences

  2011cited by this paper
• Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.

  2011cited by this paper
• Human cytomegalovirus and kidney transplantation: a clinician's update.

  2011cited by this paper
• Cytomegalovirus infections during pregnancy

  2011cited by this paper
• Human Placental Pericytes Poorly Stimulate and Actively Regulate Allogeneic CD4 T Cell Responses

  2011cited by this paper
• Morphology and properties of pericytes.

  2011cited by this paper
• Attribution of congenital cytomegalovirus infection to primary versus non-primary maternal infection.

  2011cited by this paper
• Pericytes regulate the blood–brain barrier

  2010cited by this paper
• Pericyte-Mediated Regulation of Capillary Diameter: A Component of Neurovascular Coupling in Health and Disease

  2010cited by this paper
• A New Possible Function for Placental Pericytes

  2010cited by this paper
• Cytomegalovirus infection in pregnancy.

  2010cited by this paper
• Cytomegalovirus risk factors in renal transplantation with modern immunosuppression

  2010cited by this paper
• Neuropathogenesis of Congenital Cytomegalovirus Infection: Disease Mechanisms and Prospects for Intervention

  2009cited by this paper
• Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche.

  2009cited by this paper
• Guidelines on CMV congenital infection

  2009cited by this paper
• Pericytes: pluripotent cells of the blood brain barrier.

  2008cited by this paper
• Incidence of cytomegalovirus infection among the general population and pregnant women in the United States

  2007cited by this paper
• Clinical findings and adverse outcome in neonates with symptomatic congenital cytomegalovirus (SCCMV) infection

  2006cited by this paper
• Pericytes and vascular stability.

  2006cited by this paper
• Cytomegalovirus-related congenital nephrotic syndrome with diffuse mesangial sclerosis

  2006cited by this paper
• Viral infection in the renal transplant recipient.

  2005cited by this paper
• The critical component to establish in vitro BBB model: Pericyte.

  2005cited by this paper
• Posttranscriptional Suppression of Interleukin-6 Production by Human Cytomegalovirus

  2005cited by this paper
• Congenital cytomegalovirus infection: association between virus burden in infancy and hearing loss.

  2005cited by this paper
• The role of pericytes in blood-vessel formation and maintenance.

  2005cited by this paper
• The blood-brain barrier: an overview: structure, regulation, and clinical implications.

  2004cited by this paper
• Impact of early cytomegalovirus infection and disease on long-term recipient and kidney graft survival.

  2004cited by this paper
• The association of prior cytomegalovirus infection with neovascular age-related macular degeneration.

  2004cited by this paper
• Elevated Placental Soluble Vascular Endothelial Growth Factor Receptor-1 Inhibits Angiogenesis in Preeclampsia

  2004cited by this paper
• Development of the glomerular mesangium

  2004cited by this paper
• Development of the blood-brain barrier

  2003cited by this paper
• Endothelium‐specific platelet‐derived growth factor‐B ablation mimics diabetic retinopathy

  2002cited by this paper
• The Impact of Cytomegalovirus Infection and Disease on Rejection Episodes in Renal Allograft Recipients

  2002cited by this paper
• Angiogenesis of the blood‐brain barrier in vitro and the function of cerebral pericytes

  2002cited by this paper
• Viral infections after renal transplantation.

  2001cited by this paper
• Multifunctional strands in tight junctions

  2001cited by this paper
• Cytomegalovirus in renal transplantation.

  2001cited by this paper
• Elevated serum cytokines are associated with cytomegalovirus infection and disease in bone marrow transplant recipients.

  1999cited by this paper
• Pericytes of term human foeto-placental microvessels: ultrastructure and visualization.

  1999cited by this paper
• A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF.

  1998cited by this paper
• Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli.

  1998cited by this paper
• In vitro models for the blood-brain barrier.

  1998cited by this paper
• Role of the CNS microvascular pericyte in the blood‐brain barrier

  1998cited by this paper
• Remission of IgA nephropathy following treatment of cytomegalovirus infection with ganciclovir.

  1998cited by this paper
• In vitro models of the blood-brain barrier.

  1998cited by this paper
• Progressive and fluctuating sensorineural hearing loss in children with asymptomatic congenital cytomegalovirus infection.

  1997cited by this paper
• Neuroradiographic findings in the newborn period and long-term outcome in children with symptomatic congenital cytomegalovirus infection.

  1997cited by this paper
• Acquired immunodeficiency syndrome and the eye--1996.

  1996cited by this paper
• Pericyte physiology

  1993cited by this paper
• Acquired immunodeficiency syndrome and the eye.

  1992cited by this paper
• Symptomatic congenital cytomegalovirus infection: neonatal morbidity and mortality.

  1992cited by this paper
• The outcome of congenital cytomegalovirus infection in relation to maternal antibody status

  1992cited by this paper
• CMV infection in various cell types of human kidney.

  1992cited by this paper
• Cytomegalovirus infection of human kidney cells in vitro.

  1991cited by this paper
• Cytomegalovirus replicates efficiently in human kidney mesangial cells.

  1988cited by this paper
• Infection in the Renal and Liver Transplant Patient

  1988cited by this paper
• The glomerular mesangial cell: an expanding role for a specialized pericyte

  1987cited by this paper
• Primary cytomegalovirus infection in pregnancy. Incidence, transmission to fetus, and clinical outcome.

  1986cited by this paper
• The pericyte--a review.

  1986cited by this paper
• Der feinere Bau der Blutcapillaren

  1923cited by this paper
• Handbuch der Lehre von den Geweben des Menschen und der Thiere

  year unknowncited by this paper

• Congenital Zika virus infection in laboratory animals: a comparative review highlights translational studies on the maternal-foetal interface

  2025cites this paper
• Nanoparticle Interactions with the Blood Brain Barrier: Insights from Drosophila and Implications for Human Astrocyte Targeted Therapies

  2025cites this paper
• Human herpesvirus reactivation and its potential role in the pathogenesis of post-acute sequelae of SARS-CoV-2 infection

  2024cites this paper
• iPSC-derived blood-brain barrier modeling reveals APOE isoform-dependent interactions with amyloid beta

  2024cites this paper
• Single-cell transcriptomes reveal a molecular link between diabetic kidney and retinal lesions

  2023cites this paper
• Decoding human cytomegalovirus for the development of innovative diagnostics to detect congenital infection

  2023cites this paper
• Cytomegalovirus and cardiovascular disease: a hypothetical role for viral G protein-coupled receptors in hypertension.

  2023cites this paper
• Occludin regulates HIV-1 infection by modulation of the interferon stimulated OAS gene family

  2023cites this paper
• Perivascular Mesenchymal Stem/Stromal Cells, an Immune Privileged Niche for Viruses?

  2022influential citation
• Current Status of In vitro Models of the Blood-Brain Barrier.

  2022cites this paper
• The impact of pericytes on the stability of microvascular networks in response to nanoparticles

  2022cites this paper
• Association of Serum Cystatin C With Cerebral Small Vessel Disease in Community-Based Population

  2022cites this paper
• Role of Pericytes in Diabetic Angiogenesis

  2021cites this paper
• Novel Infection of Pericytes by Andes Virus Enhances Endothelial Cell Permeability.

  2021cites this paper
• Blood and Lymphatic Vasculatures On-Chip Platforms and Their Applications for Organ-Specific In Vitro Modeling

  2020cites this paper
• Implications of TORCH Diseases in Retinal Development—Special Focus on Congenital Toxoplasmosis

  2020cites this paper
• Interactions between Amyloid-Β Proteins and Human Brain Pericytes: Implications for the Pathobiology of Alzheimer’s Disease

  2020cites this paper
• Interactions between Amyloid-Β Proteins and Human Brain Pericytes: Implications for the Pathobiology of Alzheimer’s Disease

  2020cites this paper