Meta-analysis for a therapeutic target involved in the activation of the genes associated with C3 glomerulopathy

The term C3 glomerulopathy is a group of related conditions that cause the kidneys to malfunction, characterized by the presence of glomerular deposits composed of C3 in the absence of significant amounts of Ig. On the basis of electron microscopy appearance, the subsets of C3 glomerulopathy include dense deposit disease (DDD) and C3 glomerulonephritis (C3GN). Affected individuals may have particularly low levels of a protein called complement component 3 (C3) in the blood. Glomerular diseases include many conditions with a variety of genetic and environmental causes, but they fall into two major categories; Glomerulonephritis and Glomerulosclerosis. Although glomerulonephritis and glomerulosclerosis have different causes, they can both lead to kidney failure, also called end-stage renal disease (ESRD); it is the final stage of chronic kidney disease. It can be caused by other health problems that have done permanent damage to kidneys little by little, over time. In this study we examined Gene Ontology (GO) terms, that are used to assess the results of microarray experiments. However, we propose testing groups of GO terms rather than individual terms, to improve the interpretation of gene set enrichment reduce dependence between statistical tests and improve the interpretation of results. The data analyzed here focus on the differences in microarray gene expression associated with C3 glomerulopathy in two disease subtypes.

• Publication year

  2019

• Venue

  Proceedings of the New Challenges in Data Sciences: Acts of the Second Conference of the Moroccan Classification Society

• Publication date

  2019-03-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1145/3314074.3314095
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Reactome enhanced pathway visualization

  2017cited by this paper
• ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization.

  2016cited by this paper
• An end to end workflow for differential gene expression using Affymetrix microarrays

  2016cited by this paper
• Microarray Meta-Analysis and Cross-Platform Normalization: Integrative Genomics for Robust Biomarker Discovery

  2015cited by this paper
• GOexpress: an R/Bioconductor package for the identification and visualisation of robust gene ontology signatures through supervised learning of gene expression data

  2015cited by this paper
• C3 Glomerulopathy

  2015cited by this paper
• Re-Annotator: Annotation Pipeline for Microarray Probe Sequences

  2015cited by this paper
• ArrayExpress update—simplifying data submissions

  2014cited by this paper
• Update on C3 glomerulopathy

  2014cited by this paper
• Syndromes of thrombotic microangiopathy.

  2014cited by this paper
• Genetics of Atypical Hemolytic Uremic Syndrome (aHUS)

  2014cited by this paper
• C3 Glomerulopathy: The Genetic and Clinical Findings in Dense Deposit Disease and C3 Glomerulonephritis

  2014cited by this paper
• Defining the complement biomarker profile of C3 glomerulopathy.

  2014cited by this paper
• Dense Deposit Disease and C3 Glomerulopathy

  2013cited by this paper
• Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome.

  2013cited by this paper
• C3 glomerulopathy: consensus report

  2013cited by this paper
• Cardiovascular , Pulmonary and Renal Pathology Human Nephrosclerosis Triggers a Hypoxia-Related Glomerulopathy

  2010cited by this paper
• Et al

  2008cited by this paper
• A genome-wide association study of global gene expression

  2007cited by this paper
• Gene set enrichment analysis with topGO

  2006cited by this paper
• RankProd: a bioconductor package for detecting differentially expressed genes in meta-analysis

  2006cited by this paper
• Antibody Inhibitors to von Willebrand Factor Metalloproteinase and Increased Binding of von Willebrand Factor to Platelets in Ticlopidine-Associated Thrombotic Thrombocytopenic Purpura

  2000cited by this paper
• Genomics, gene expression and DNA arrays

  2000cited by this paper
• Array of hope

  1999cited by this paper

• Optimizing gene selection and module identification via ontology-based scoring and deep learning

  2025cites this paper
• Functional Cluster Analysis of Glomerular Disease

  2022cites this paper
• Adjustment of p-value expression to ontology using machine learning for genetic prediction, prioritization, interaction, and its validation in glomerular disease

  2022cites this paper