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Genetic and Molecular Mechanisms Associated with Antibiotic Resistance in Methicillin Resistant Staphylococcus aureus (MRSA): A Review

Diso S.U.,Mukhtar M.D,Dutsin-Ma U.A,A. M.

Published 2018 in Annals of Microbiology and Infectious Diseases

ABSTRACT

Staphylococcus aureus is a bacterium of significant importance because of its ability to cause a wide range of diseases and capacity to adapt to diverse environmental forms [1]. The organism colonizes skin, skin glands and mucous membrane, causing infections both in human and animals such as rashes, inflammations of bones and the meninges as well as septicaemia [2]. In addition, S. aureus causes inflammation of the mammary gland in bovine and the lower part of the foot in poultry [3]. Staphylococcus aureus remains one of the most significant pathogens causing disease in animals and human and methicillin-resistant S. aureus (MRSA) is ranked among the most important and common pathogens resistant to multiple antibiotics all over the world. Penicillin and its derivatives, including methicillin have been used for the treatments of infections caused by S. aureus [4]. However, certain strains of S. aureus developed resistance known as methicillin resistant Staphylococcus aureus (MRSA).

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