Using chemical inhibitors to probe AAA protein conformational dynamics and cellular functions.

The AAA proteins are a family of enzymes that play key roles in diverse dynamic cellular processes, ranging from proteostasis to directional intracellular transport. Dysregulation of AAA proteins has been linked to several diseases, including cancer, suggesting a possible therapeutic role for inhibitors of these enzymes. In the past decade, new chemical probes have been developed for AAA proteins including p97, dynein, midasin, and ClpC1. In this review, we discuss how these compounds have been used to study the cellular functions and conformational dynamics of AAA proteins. We discuss future directions for inhibitor development and early efforts to utilize AAA protein inhibitors in the clinical setting.

• Publication year

  2019

• Venue

  Current Opinion in Chemical Biology

• Publication date

  2019-06-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.cbpa.2019.02.019PMID 30913482PMCID PMC6880239
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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