Ectodomain-Specific E-Cadherin Antibody Suppresses Skin SCC Growth and Reduces Tumor Grade: A Multitargeted Therapy Modulating RTKs and the PTEN–p53–MDM2 Axis

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Molecular Cancer Therapeutics

• Publication date

  2014-04-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1535-7163.MCT-13-0971PMID 24748654
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Carcinoma cells induce lumen filling and EMT in epithelial cells through soluble E-cadherin-mediated activation of EGFR

  2015cited by this paper
• Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways

  2015cited by this paper
• Soluble‐E‐cadherin activates HER and IAP family members in HER2+ and TNBC human breast cancers

  2014cited by this paper
• Soluble E-cadherin: a critical oncogene modulating receptor tyrosine kinases, MAPK and PI3K/Akt/mTOR signaling

  2014cited by this paper
• Monoclonal Antibody against the Ectodomain of E-Cadherin (DECMA-1) Suppresses Breast Carcinogenesis: Involvement of the HER/PI3K/Akt/mTOR and IAP Pathways

  2013influential reference
• PI3K‐independent AKT activation in cancers: A treasure trove for novel therapeutics

  2012influential reference
• From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma.

  2012cited by this paper
• Cetuximab in Refractory Skin Cancer Treatment

  2012cited by this paper
• PTEN at a glance

  2012cited by this paper
• PTEN level in tumor suppression: how much is too little?

  2011cited by this paper
• Phase II study of cetuximab as first-line single-drug therapy in patients with unresectable squamous cell carcinoma of the skin.

  2011cited by this paper
• Dual inhibition of epidermal growth factor receptor and insulin‐like growth factor receptor I: Reduction of angiogenesis and tumor growth in cutaneous squamous cell carcinoma

  2011cited by this paper
• Inhibition of Epidermal Growth Factor Receptor and PI3K/Akt Signaling Suppresses Cell Proliferation and Survival through Regulation of Stat3 Activation in Human Cutaneous Squamous Cell Carcinoma

  2010cited by this paper
• The PI3K pathway as drug target in human cancer.

  2010cited by this paper
• p53-based cancer therapy.

  2010cited by this paper
• PI(3)King Apart PTEN's Role in Cancer

  2010cited by this paper
• PTEN: new insights into its regulation and function in skin cancer.

  2009cited by this paper
• Cytoplasmic functions of the tumour suppressor p53

  2009influential reference
• Tenets of PTEN tumor suppression.

  2008cited by this paper
• Inhibition of Mammalian Target of Rapamycin by Rapamycin Causes the Regression of Carcinogen-Induced Skin Tumor Lesions

  2008cited by this paper
• Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway.

  2007cited by this paper
• c-Jun promotes cellular survival by suppression of PTEN

  2007cited by this paper
• A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth

  2007cited by this paper
• Sequential down-regulation of E-cadherin with squamous cell carcinoma progression: loss of E-cadherin via a prostaglandin E2-EP2 dependent posttranslational mechanism.

  2007influential reference
• An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations.

  2007influential reference
• Mitogen-activated Protein Kinase Kinase-4 Promotes Cell Survival by Decreasing PTEN Expression through an NFκB-dependent Pathway*

  2006cited by this paper
• Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs.

  2006cited by this paper
• Loss of E‐cadherin mediated cell–cell adhesion as an early trigger of apoptosis induced by photodynamic treatment

  2005cited by this paper
• Role of PI3K/Akt signaling in insulin‐like growth factor‐1 (IGF‐1) skin tumor promotion

  2005cited by this paper
• The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

  2004cited by this paper
• Soluble E-cadherin is an independent pretherapeutic factor for long-term survival in gastric cancer.

  2003cited by this paper
• Skin cancers after organ transplantation.

  2003cited by this paper
• PTEN Induces Cell Cycle Arrest by Decreasing the Level and Nuclear Localization of Cyclin D1

  2003cited by this paper
• Skin cancers after organ transplantation.

  2003cited by this paper
• Regulation of tumor suppressors by nuclear-cytoplasmic shuttling.

  2003cited by this paper
• The role of an 80 kDa fragment of E-cadherin in the metastatic progression of prostate cancer.

  2003cited by this paper
• The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network.

  2002cited by this paper
• PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to Chemotherapy*

  2002cited by this paper
• Disruption of cell-cell adhesion enhances antibody-dependent cellular cytotoxicity: implications for antibody-based therapeutics of cancer.

  2002cited by this paper
• An Intact Overexpressed E-cadherin/α,β-Catenin Axis Characterizes the Lymphovascular Emboli of Inflammatory Breast Carcinoma

  2001cited by this paper
• Regulation of PTEN transcription by p53.

  2001cited by this paper
• HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

  2001cited by this paper
• An intact overexpressed E-cadherin/alpha,beta-catenin axis characterizes the lymphovascular emboli of inflammatory breast carcinoma.

  2001cited by this paper
• A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

  2001cited by this paper
• Constitutive expression of erbB2 in epidermis of transgenic mice results in epidermal hyperproliferation and spontaneous skin tumor development

  2000cited by this paper
• New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.

  1999cited by this paper
• Role of Poly(ADP-ribose) Polymerase (PARP) Cleavage in Apoptosis

  1999cited by this paper
• E-cadherin Regulates Anchorage-independent Growth and Survival in Oral Squamous Cell Carcinoma Cells*

  1998cited by this paper
• Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

  1997cited by this paper
• Regulation of p53 stability by Mdm2

  1997cited by this paper
• Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases

  1997influential reference
• Soluble E-cadherin fragments increased in circulation of cancer patients.

  1994cited by this paper
• A survey of transformation markers in differentiating epidermal cell lines in culture.

  1980cited by this paper
• Tumorigenesis and Neoplastic Progression Erbb2 Suppresses DNA Damage-Induced Checkpoint Activation and UV-Induced Mouse Skin Tumorigenesis

  year unknowncited by this paper

• Cellular senescence promotes cancer metastasis by enhancing soluble E-cadherin production

  2021influential citation
• An Overview of Paris polyphylla, a Highly Vulnerable Medicinal Herb of Eastern Himalayan Region for Sustainable Exploitation

  2020cites this paper
• TWEAK/Fn14 Interaction Confers Aggressive Properties to Cutaneous Squamous Cell Carcinoma.

  2019cites this paper
• sEcad and EGF Levels Increased in Urine of Non-ferrous Metal Workers and Medium of Uroepithelial Cell Line Treated by Arsenic

  2018cites this paper
• A Review on Paris Polyphylla Smith : As an Effective andAlternative Treatment of Cancer

  2018cites this paper
• Involvement of microRNAs‐MMPs‐E‐cadherin in the migration and invasion of gastric cancer cells infected with Helicobacter pylori

  2018cites this paper
• Correlation of E-cadherin gene polymorphisms and epidermal growth factor receptor mutation in lung adenocarcinoma

  2018cites this paper
• Targeting temporal dynamics of microenvironmental factors halts tumor migration and alleviates effects of dynamic tumor heterogeneity

  2017influential citation
• Cadherins and their Role in Malignant Transformation: Implications for Skin Cancer Progression

  2016cites this paper
• Beyond a tumor suppressor: Soluble E‐cadherin promotes the progression of cancer

  2016cites this paper
• miR-199a-5p induces cell invasion by suppressing E-cadherin expression in cutaneous squamous cell carcinoma

  2016cites this paper
• Does the nature of residual immune function explain the differential risk of non‐melanoma skin cancer development in immunosuppressed organ transplant recipients?

  2016cites this paper
• The effects of exogenous E-cadherin inhibition in MCF-7 mammary epithelial cells

  2015cites this paper
• Soluble E-cadherin as a microenvironmental factor which enhances tumor progression

  2015cites this paper
• Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways

  2015cites this paper
• Carcinoma cells induce lumen filling and EMT in epithelial cells through soluble E-cadherin-mediated activation of EGFR

  2015cites this paper