Fluctuation-induced hydrodynamic coupling in an asymmetric, anisotropic dumbbell

We recently introduced a model of an asymmetric dumbbell made of two hydrodynamically coupled subunits as a minimal model for a macromolecular complex, in order to explain the observation of enhanced diffusion of catalytically active enzymes. It was shown that internal fluctuations lead to a negative contribution to the overall diffusion coefficient and that the fluctuation-induced contribution is controlled by the strength of the interactions between the subunits and their asymmetry. We develop the model by studying the effect of anisotropy on the diffusion properties of a modular structure. Using a moment expansion method we derive an analytic form for the long-time diffusion coefficient of an asymmetric, anisotropic dumbbell and show systematically its dependence on internal and external symmetry. The method provides a tractable, analytical route for studying the stochastic dynamics of dumbbell models. The present work opens the way to more detailed descriptions of the effect of hydrodynamic interactions on the diffusion and transport properties of biomolecules with complex structures.

• Publication year

  2017

• Venue

  The European Physical Journal E : Soft matter

• Publication date

  2017-12-18

• Fields of study

  Medicine, Physics, Chemistry

• Identifiers
  DOI 10.1140/epje/i2019-11799-5arXiv 1712.06418PMID 30915599
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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