The role of toll‐like receptor 4 and mast cell in the ameliorating effect of electroacupuncture on visceral hypersensitivity in rats

Visceral hypersensitivity is one of the main pathogenesis of irritable bowel syndrome (IBS) and mast cell activation is closely related to visceral hypersensitivity. As a critical molecule of the innate immune system, toll‐like receptor 4 (TLR4) may modulate the activation of mast cell. Alleviating effect of electroacupuncture (EA) on visceral hypersensitivity has been proved, whereas, whether the TLR4 and mast cell is involved in this process remains unclear.

• Publication year

  2019

• Venue

  Neurogastroenterology and Motility

• Publication date

  2019-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/nmo.13583PMID 30916854
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functional gastrointestinal disorders

  2023cited by this paper
• Electroacupuncture Improves IBS Visceral Hypersensitivity by Inhibiting the Activation of Astrocytes in the Medial Thalamus and Anterior Cingulate Cortex

  2020cited by this paper
• Potential neuro-immune therapeutic targets in irritable bowel syndrome

  2020cited by this paper
• Effect of the interleukin 10 polymorphisms on interleukin 10 production and visceral hypersensitivity in Chinese patients with diarrhea-predominant irritable bowel syndrome

  2019cited by this paper
• Role of Toll Like Receptors in Irritable Bowel Syndrome: Differential Mucosal Immune Activation According to the Disease Subtype

  2012cited by this paper
• A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome

  2012cited by this paper
• Visceral hypersensitivity in irritable bowel syndrome

  2011cited by this paper
• Altered peripheral toll‐like receptor responses in the irritable bowel syndrome

  2011cited by this paper
• Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions

  2010cited by this paper
• Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome.

  2010cited by this paper
• Toll-Like Receptor mRNA Expression Is Selectively Increased in the Colonic Mucosa of Two Animal Models Relevant to Irritable Bowel Syndrome

  2009cited by this paper
• Effects of electroacupuncture on gastric motility and heart rate variability in conscious rats.

  2008cited by this paper
• P2X receptor-mediated visceral hyperalgesia in a rat model of chronic visceral hypersensitivity

  2008cited by this paper
• Repeated electro-acupuncture attenuates chronic visceral hypersensitivity and spinal cord NMDA receptor phosphorylation in a rat irritable bowel syndrome model.

  2008cited by this paper
• Toll-like receptors in the respiratory system: Their roles in inflammation

  2008cited by this paper
• Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system.

  2008cited by this paper
• Altered rectal perception in irritable bowel syndrome is associated with symptom severity.

  2007cited by this paper
• The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats.

  2007cited by this paper
• Acupuncture treatment in gastrointestinal diseases: a systematic review.

  2007cited by this paper
• Electro-acupuncture relieves chronic visceral hyperalgesia in rats.

  2005cited by this paper
• Therapeutic roles of acupuncture in functional gastrointestinal disorders

  2004cited by this paper
• Review article: therapeutic roles of acupuncture in functional gastrointestinal disorders.

  2004cited by this paper
• Electroacupuncture at Hoku elicits dual effect on autonomic nervous system in anesthetized rats.

  2002cited by this paper
• Prevalence of rectal hypersensitivity in patients with irritable bowel syndrome and its clinical subgroups.

  2002cited by this paper

• Mecanismos fisiológicos de la electroacupuntura médica, y su utilidad clínica en dolor nociplástico: revisión de la literatura

  2026cites this paper
• Mast cell degranulation mediates analgesic effects of acupuncture at different stimulation durations in arthritic rats

  2025cites this paper
• Role of AQP1 in the Ameliorating Effect of Electroacupuncture in a Rodent Model of Visceral Hypersensitivity

  2025cites this paper
• Changji’an formula alleviates visceral hypersensitivity of a post-inflammatory IBS-D mouse model via NGF/TrkA signaling pathway

  2025cites this paper
• Acupuncture and moxibustion intervention in functional dyspepsia: Gastric and duodenal regulation

  2024cites this paper
• Traditional Chinese medicine for functional gastrointestinal disorders and inflammatory bowel disease: narrative review of the evidence and potential mechanisms involving the brain-gut axis

  2024cites this paper
• Toll-like receptor 4 plays a vital role in irritable bowel syndrome: a scoping review

  2024cites this paper
• The gut-brain and gut-macrophage contribution to gastrointestinal dysfunction with systemic inflammation.

  2024cites this paper
• Electroacupuncture alleviates water avoidance stress-induced irritable bowel syndrome in mice by improving intestinal barrier functions and suppressing the expression of inflammatory cytokines.

  2023cites this paper
• Central mechanisms of acupuncture in relieving visceral hypersensitivity in functional gastrointestinal disorders: A narrative review

  2023cites this paper
• The efficacy and neural mechanism of acupuncture therapy in the treatment of visceral hypersensitivity in irritable bowel syndrome

  2023cites this paper
• Multi-effective characteristics and advantages of acupuncture in COVID-19 treatment

  2023cites this paper
• Multi-omics for biomarker approaches in the diagnostic evaluation and management of abdominal pain and irritable bowel syndrome: what lies ahead

  2023cites this paper
• The effect and mechanism of Sancao Lichang Decoction on Diarrhea-predominant Irritable Bowel Syndrome by regulating TLR4/MyD88/NF-κB pathway.

  2023cites this paper
• The protective effects of electroacupuncture on intestinal barrier lesions in IBS and UC model

  2023cites this paper
• Ameliorating effects of electroacupuncture on the low‐grade intestinal inflammation in rat model of diarrhea‐predominant irritable bowel syndrome

  2022cites this paper
• Potential Mechanisms of Acupuncture for Functional Dyspepsia Based on Pathophysiology

  2022cites this paper
• Revealing the magic of acupuncture based on biological mechanisms: A literature review.

  2022cites this paper
• Mast cell mediation of visceral sensation and permeability in irritable bowel syndrome

  2022cites this paper
• Peripheral apelin mediates visceral hypersensitivity and impaired gut barrier in a rat irritable bowel syndrome model.

  2022cites this paper
• Electroacupuncture Attenuates Post-Inflammatory IBS-Associated Visceral and Somatic Hypersensitivity and Correlates With the Regulatory Mechanism of Epac1–Piezo2 Axis

  2022cites this paper
• Neuro-Immune Modulation Effects of Sacral Nerve Stimulation for Visceral Hypersensitivity in Rats

  2021cites this paper
• Electroacupuncture at ST36 Relieves Visceral Hypersensitivity via the NGF/TrkA/TRPV1 Peripheral Afferent Pathway in a Rodent Model of Post-Inflammation Rectal Hypersensitivity

  2021cites this paper
• Peripheral and Spinal Mechanisms Involved in Electro-Acupuncture Therapy for Visceral Hypersensitivity

  2021cites this paper
• Treatment of Irritable Bowel Syndrome by Chinese Medicine: A Review

  2021cites this paper
• Regulation of serum microRNA expression by acupuncture in patients with diarrhea-predominant irritable bowel syndrome

  2021cites this paper
• Potential neuro-immune therapeutic targets in irritable bowel syndrome

  2020cites this paper
• Electroacupuncture Improves IBS Visceral Hypersensitivity by Inhibiting the Activation of Astrocytes in the Medial Thalamus and Anterior Cingulate Cortex

  2020cites this paper
• Electroacupuncture: A New Approach for Improved Postoperative Sleep Quality After General Anesthesia

  2020cites this paper
• Electroacupuncture: A New Approach for Improved Postoperative Sleep Quality After General Anesthesia

  2020cites this paper
• Corrigendum

  2020cites this paper
• Electroacupuncture: A New Approach for Improved Postoperative Sleep Quality After General Anesthesia

  2020cites this paper
• Veränderungen der Darm-Gehirn-Achse beim Reizdarmsyndrom – Ein Update

  2019cites this paper
• Effect of the interleukin 10 polymorphisms on interleukin 10 production and visceral hypersensitivity in Chinese patients with diarrhea-predominant irritable bowel syndrome

  2019influential citation