Functionalized chitosan-modified defect-related luminescent mesoporous silica nanoparticles as new inhibitors for hIAPP aggregation

Human islet amyloid polypeptide (hIAPP or amylin) forms the amyloid deposits that is an important factor in the induction of type II diabetes. Accordingly, it is essential to efficiently and accurately inhibit the aggregation of hIAPP for the treatment and prevention of the disease. Here, defect mesoporous silica (DLMSN), with blue fluorescence, can perfectly achieve the accurate positioning in cells or organisms. DL@CS@NF cannot only specifically bind to a hIAPP monomer, but also effectively inhibit hIAPP aggregation, reduce cytotoxicity and overcome the instability and inefficiency of NF(N-Me)GA(N-Me)IL (NF). Furthermore, DL@CS@NF nanoparticles can significantly improve the survival rate of islet cells, stabilize the mitochondrial membrane potential, reduce the content of intracellular reactive oxygen species. In summary, DL@CS@NF nanoparticles may have broader implications in inhibiting the aggregation of hIAPP and reducing cytotoxicity.

• Publication year

  2019

• Venue

  Nanotechnology

• Publication date

  2019-05-08

• Fields of study

  Physics, Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1088/1361-6528/ab13efPMID 30917341
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An innovative MWCNTs/DOX/TC nanosystem for chemo-photothermal combination therapy of cancer.

  2017cited by this paper
• Dual-aptamer-modified-mesoporous silica nanoparticles loading doxorubicin for high efficient restraining cancer metastasis

  2016cited by this paper
• The Role of Narrative and Other-Referencing in Attenuating Psychological Reactance to Diabetes Self-Care Messages

  2016cited by this paper
• Advances in silica based nanoparticles for targeted cancer therapy.

  2016cited by this paper
• Ceria/POMs hybrid nanoparticles as a mimicking metallopeptidase for treatment of neurotoxicity of amyloid-β peptide.

  2016cited by this paper
• An ultrathin graphitic carbon nitride nanosheet: a novel inhibitor of metal-induced amyloid aggregation associated with Alzheimer's disease.

  2016cited by this paper
• An integrated nanoplatform for theranostics via multifunctional core-shell ferrite nanocubes.

  2016cited by this paper
• Analysis of the ability of pramlintide to inhibit amyloid formation by human islet amyloid polypeptide reveals a balance between optimal recognition and reduced amyloidogenicity.

  2015cited by this paper
• Synthetic chemically modified mrna-based delivery of cytoprotective factor promotes early cardiomyocyte survival post-acute myocardial infarction.

  2015cited by this paper
• Recent development of silica nanoparticles as delivery vectors for cancer imaging and therapy.

  2014cited by this paper
• Enzyme‐Responsive Cell‐Penetrating Peptide Conjugated Mesoporous Silica Quantum Dot Nanocarriers for Controlled Release of Nucleus‐Targeted Drug Molecules and Real‐Time Intracellular Fluorescence Imaging of Tumor Cells

  2014cited by this paper
• Biodistribution and toxicity assessment of europium-doped Gd2O3 nanotubes in mice after intraperitoneal injection

  2014cited by this paper
• Defining the Molecular Basis of Amyloid Inhibitors: Human Islet Amyloid Polypeptide–Insulin Interactions

  2014cited by this paper
• Epigallocatechin-3-gallate (EGCG)-stabilized selenium nanoparticles coated with Tet-1 peptide to reduce amyloid-β aggregation and cytotoxicity.

  2014cited by this paper
• Developing Functionalized Dendrimer‐Like Silica Nanoparticles with Hierarchical Pores as Advanced Delivery Nanocarriers

  2013cited by this paper
• NIR light controlled photorelease of siRNA and its targeted intracellular delivery based on upconversion nanoparticles.

  2013cited by this paper
• Facile large-scale synthesis of monodisperse mesoporous silica nanospheres with tunable pore structure.

  2013cited by this paper
• Multifunctional Mesoporous Silica Nanoparticles for Cancer‐Targeted and Controlled Drug Delivery

  2012cited by this paper
• Modeling the Interface between Islet Amyloid Polypeptide and Insulin-Based Aggregation Inhibitors: Correlation to Aggregation Kinetics and Membrane Damage

  2012cited by this paper
• Inhibitory action of macrocyclic platiniferous chelators on metal-induced Aβ aggregation

  2012cited by this paper
• A magnetic, reversible pH-responsive nanogated ensemble based on Fe3O4 nanoparticles-capped mesoporous silica.

  2011cited by this paper
• One-pot microwave synthesis of water-dispersible, ultraphoto- and pH-stable, and highly fluorescent silicon quantum dots.

  2011cited by this paper
• The amyloid formation mechanism in human IAPP: dimers have β-strand monomer-monomer interfaces.

  2011cited by this paper
• Structural polymorphism of human islet amyloid polypeptide (hIAPP) oligomers highlights the importance of interfacial residue interactions.

  2011cited by this paper
• Islet amyloid polypeptide, islet amyloid, and diabetes mellitus.

  2011cited by this paper
• Porcine islet amyloid polypeptide fragments are refractory to amyloid formation

  2011cited by this paper
• Self-activated luminescent and mesoporous strontium hydroxyapatite nanorods for drug delivery.

  2010cited by this paper
• The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity

  2010cited by this paper
• The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity.

  2010cited by this paper
• Molecular mechanism of Thioflavin-T binding to amyloid fibrils.

  2010cited by this paper
• Effects of cyclen and cyclam on zinc(II)- and copper(II)-induced amyloid beta-peptide aggregation and neurotoxicity.

  2009cited by this paper
• Membrane permeabilization by Islet Amyloid Polypeptide.

  2009cited by this paper
• Cellular membrane disruption by amyloid fibrils involved intermolecular disulfide cross-linking.

  2009cited by this paper
• Structure of α-Helical Membrane-bound Human Islet Amyloid Polypeptide and Its Implications for Membrane-mediated Misfolding*

  2008cited by this paper
• Interactions between alginate and chitosan biopolymers characterized using FTIR and XPS.

  2007cited by this paper
• Inhibition of hIAPP amyloid-fibril formation and apoptotic cell death by a designed hIAPP amyloid- core-containing hexapeptide.

  2005cited by this paper
• Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes.

  2004cited by this paper
• Inhibition of amyloid fibril formation by peptide analogues modified with alpha-aminoisobutyric acid.

  2004cited by this paper
• Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity.

  2002cited by this paper
• Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology.

  2001cited by this paper
• Inhibition of beta-amyloid(40) fibrillogenesis and disassembly of beta-amyloid(40) fibrils by short beta-amyloid congeners containing N-methyl amino acids at alternate residues.

  2001cited by this paper
• Inhibition of toxicity in the beta-amyloid peptide fragment beta -(25-35) using N-methylated derivatives: a general strategy to prevent amyloid formation.

  2000cited by this paper
• Inhibition of Toxicity in the β-Amyloid Peptide Fragment β-(25–35) Using N-Methylated Derivatives

  2000cited by this paper
• Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity.

  1995cited by this paper
• Structure‐Activity Analyses of β‐Amyloid Peptides: Contributions of the β25–35 Region to Aggregation and Neurotoxicity

  1995cited by this paper

• Modulating the Aggregation of Amyloid Proteins by Silica Nanoparticles

  2025cites this paper
• Resveratrol-laden mesoporous silica nanoparticles regulate the autophagy and apoptosis via ROS-mediated p38-MAPK/HIF-1a /p53 signaling in hypertrophic scar fibroblasts

  2024cites this paper
• Interfacial metal atoms of metallic nano-chaperones on modulating amyloid fibrillation

  2024cites this paper
• Gold Nanoclusters Enhance the Efficacy of the Polymer-Based Chaperone in Restoring and Maintaining the Native Conformation of Human Islet Amyloid Polypeptide.

  2023cites this paper
• Chitosan oligosaccharides inhibit the fibrillation of insulin and disassemble its preformed fibrils.

  2023cites this paper
• Targeted delivery and apoptosis induction activity of peptide-transferrin targeted mesoporous silica encapsulated resveratrol in MCF-7 cells.

  2022cites this paper
• Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery

  2020cites this paper
• Understanding the Structure, Toxicity and Inhibition of IAPP at the Nanoscale

  2020cites this paper
• Introduction and Fundamentals of Human Islet Amyloid Polypeptide Inhibitors.

  2020cites this paper
• The impact of chemical engineering and technological advances on managing diabetes: present and future concepts.

  2020cites this paper