Medicinal Herbs Effective Against Atherosclerosis: Classification According to Mechanism of Action

Atherosclerosis is a widespread and chronic progressive arterial disease that has been regarded as one of the major causes of death worldwide. It is caused by the deposition of cholesterol, fats, and other substances in the tunica intima which leads to narrowing of the blood vessels, loss of elasticity, and arterial wall thickening, thus causing difficulty in blood flow. Natural products have been used as one of the most important strategies for the treatment and prevention of cardiovascular diseases for a long time. In recent decades, as interests in natural products including medicinal herbs have increased, many studies regarding natural compounds that are effective against atherosclerosis have been conducted. The purpose of this review is to provide a brief over-view of the natural compounds that have been used for the treatment and prevention of atherosclerosis, and their mechanisms of action based on recent research.

• Publication year

  2019

• Venue

  Biomolecules & Therapeutics

• Publication date

  2019-03-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4062/biomolther.2018.231PMID 30917628PMCID 6513182
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2017influential reference
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  2017cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013influential reference
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• Cryptotanshinone attenuates in vitro oxLDL-induced pre-lesional atherosclerotic events.

  2011cited by this paper
• Salvianolic acid B suppresses IFN-γ-induced JAK/STAT1 activation in endothelial cells.

  2011cited by this paper
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  2011cited by this paper
• Salvianolic acid B inhibits low-density lipoprotein oxidation and neointimal hyperplasia in endothelium-denuded hypercholesterolaemic rabbits.

  2011cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010influential reference
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  2010cited by this paper
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  2010cited by this paper
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  2009influential reference
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
• Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction.

  2004cited by this paper
• Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits.

  2003cited by this paper
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  2003cited by this paper

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