Poly(I:C) alters placental and fetal brain amino acid transport in a rat model of maternal immune activation

Maternal immune activation (MIA) during pregnancy is associated with increased chances of neurodevelopmental disorders including schizophrenia and autism spectrum disorder (ASD). However, the exact mechanism through which MIA contributes to altered neurodevelopment is unknown. Due to the important role that amino acids play in neurodevelopment, altered amino acid transport could play a role in neurodevelopmental disorders. Indeed, altered plasma concentrations of multiple amino acids have been reported in individuals with ASD or schizophrenia. Therefore, our objective was to determine whether virally mediated MIA induces changes in amino acid transporters in the placenta and fetal brain.

• Publication year

  2019

• Venue

  American Journal of Reproductive Immunology

• Publication date

  2019-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/aji.13115PMID 30924965
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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