Thalassemia trait and G6PD deficiency in Thai blood donors.

BACKGROUND Thalassemia trait and G6PD deficiency are asymptomatic and volunteers with these variants are eligible for blood donation. AIMS This study aimed to investigate prevalence and hematologic profiles of blood donors with thalassemia trait and G6PD deficiency and the influence of these abnormalities have on donor retention and blood component preparation. METHODS Prospectively recruited blood donors were investigated for thalassemia and G6PD deficiency. Characteristic data, hematologic profiles, proportions of prepared blood components, donor return rate within 12 months and adverse reactions in patients receiving red cell transfusions were compared among thalassemia trait, G6PD deficiency, and normal donors. RESULTS In Thai blood donors, thalassemia trait prevalence was 21.1% and G6PD deficiency prevalence based on G6PD activity was 7.7%. Blood donors with thalassemia trait had significantly lower hemoglobin, MCV, and MCH than blood donors without thalassemia trait (Hb 13.55 ± 1.00 vs. 13.96 ± 1.25 g/dL, MCV 76.70 ± 6.69 vs. 87.01 ± 5.10 fL, and MCH 25.06 ± 2.17 vs. 28.67 ± 1.91 pg, all respectively and all p < 0.01). However, the hematologic profiles of blood donors with G6PD deficiency were not significantly different from the hematologic profiles of blood donors with normal G6PD activity. No significant difference was observed among thalassemia trait, G6PD deficiency, and normal donors relative to donor retention and blood component preparation. CONCLUSION The high prevalence of thalassemia trait and G6PD deficiency in Thai blood donors observed in this study does not adversely affect donor retention and blood component preparation.

• Publication year

  2019

• Venue

  Transfusion and Apheresis Science

• Publication date

  2019-03-20

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.transci.2019.03.009PMID 30922678
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Total Antioxidant Capacity in beta-thalassemia: A systematic review and meta-analysis of case-control studies.

  2017cited by this paper
• Association of glucose-6-phosphate dehydrogenase deficiency and malaria: a systematic review and meta-analysis

  2017cited by this paper
• Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study.

  2017cited by this paper
• Donor‐variation effect on red blood cell storage lesion: A close relationship emerges

  2016cited by this paper
• Effect of Blood Donor Characteristics on Transfusion Outcomes: A Systematic Review and Meta-Analysis.

  2016cited by this paper
• Thalassemia and Hemoglobin E in Southern Thai Blood Donors

  2014cited by this paper
• Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in northern Thailand.

  2014cited by this paper
• Should blood donors be routinely screened for glucose-6-phosphate dehydrogenase deficiency? A systematic review of clinical studies focusing on patients transfused with glucose-6-phosphate dehydrogenase-deficient red cells.

  2014cited by this paper
• The α-thalassemias.

  2014cited by this paper
• A study of the predonation hemoglobin and iron status among Hong Kong Chinese blood donors

  2013cited by this paper
• Evaluation of the phenotypic test and genetic analysis in the detection of glucose-6-phosphate dehydrogenase deficiency

  2013cited by this paper
• Glucose‐6‐phosphate dehydrogenase deficiency in transfusion medicine: the unknown risks

  2013cited by this paper
• Red cell and platelet‐derived microparticles are increased in G6PD‐deficient subjects

  2012cited by this paper
• The population genetics and dynamics of the thalassemias.

  2010cited by this paper
• The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis.

  2009cited by this paper
• A scoring system for the classification of β‐thalassemia/Hb E disease severity

  2008cited by this paper
• Thalassemia among blood donors at the Hospital Universiti Sains Malaysia.

  2006cited by this paper
• Antioxidant in plasma of hemoglobin-E trait.

  2005cited by this paper
• Glucose‐6‐phosphate dehydrogenase (G6PD) mutations in Thailand: G6PD Viangchan (871G>A) is the most common deficiency variant in the Thai population

  2002cited by this paper
• Rapid detection of α‐thalassaemia deletions and α‐globin gene triplication by multiplex polymerase chain reactions

  2000cited by this paper
• Glucose-6-phosphate dehydrogenase deficiency in Thailand; its significance in the newborn.

  1999cited by this paper
• Prenatal diagnosis of β‐thalassaemia by reverse dot‐blot hybridization

  1999cited by this paper
• G6PD deficiency.

  1994cited by this paper
• THALASSEMIA IN THAILAND *

  1980cited by this paper
• Glucose-6-phosphate dehydrogenase deficiency in Chinese

  1968cited by this paper

• The variability of cell-derived microparticles and the age of healthy blood donors.

  2025cites this paper
• Screening, genetic analysis, and clinical transfusion implications of thalassaemia and glucose‐6‐phosphate dehydrogenase deficiency in blood donors

  2025influential citation
• Diagnostic Utility of a Multiplex PCR Assay in Detecting Common Mutations of the α‐Globin Gene in α‐Thalassemia

  2025cites this paper
• Survival of transfused red blood cells from a donor with alpha‐thalassemia trait in a recipient with sickle cell disease

  2024cites this paper
• Prevalence and screening of hemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency in Yemeni blood donors

  2024influential citation
• Screening, genotyping and haematological analysis of glucose‐6‐phosphate dehydrogenase deficiency in the blood donors of Wuxi City, China

  2024cites this paper
• Plasmodium knowlesi (Pk) Malaria: A Review & Proposal of Therapeutically Rational Exchange (T-REX) of Pk-Resistant Red Blood Cells

  2023cites this paper
• Diagnostic Performance of 10 Mathematical Formulae for Identifying Blood Donors with Thalassemia Trait.

  2023cites this paper
• Molecular characterization of G6PD mutations identifies new mutations and a high frequency of intronic variants in Thai females

  2023cites this paper
• Randomised controlled trial of glucose‐6‐phosphate dehydrogenase deficient versus non‐deficient red blood cell transfusion in patients with hypoproliferative anaemia

  2022cites this paper
• Prevalence of G6PD deficiency in Thai blood donors, the characteristics of G6PD deficient blood, and the efficacy of fluorescent spot test to screen for G6PD deficiency in a hospital blood bank setting

  2022cites this paper
• DIAGNOSIS OF IRON DEFICIENCY ANEMIA IN THAI FEMALE ADOLESCENTS USING RETICULOCYTE HEMOGLOBIN EQUIVALENT

  2022cites this paper
• Blood Donors with Thalassemic Trait, Glucose-6-Phosphate Dehydrogenase Deficiency Trait, and Sickle Cell Trait and Their Blood Products: Current Status and Future Perspective.

  2022cites this paper
• Current Understanding of the Relationship between Blood Donor Variability and Blood Component Quality

  2021cites this paper
• Cell-Derived Microparticles in Blood Products from Blood Donors Deficient in Glucose-6-Phosphate Dehydrogenase.

  2021cites this paper
• Hematological and molecular analysis of patients with G6PD deficiency revealed coexistent hereditary spherocytosis and alpha thalassemia

  2021influential citation
• Epidemiology of thalassemia among the hill tribe population in Thailand

  2021cites this paper
• The co-existence of glucose-6-phosphate dehydrogenase deficiency among individuals with hemoglobinopathies and their effects on red cellindices

  year unknowncites this paper