Native Ion Mobility Mass Spectrometry: When Gas-Phase Ion Structures Depend on the Electrospray Charging Process

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Journal of the American Society for Mass Spectrometry

• Publication date

  2018-12-26

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s13361-019-02152-3PMID 30924079
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2013influential reference
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