Peripheral localization of the epithelial sodium channel in the apical membrane of bronchial epithelial cells

I. Musante,P. Scudieri,Arianna Venturini,D. Guidone,E. Caci,S. Castellani,M. Conese,L. Galietta

Published 2019 in Experimental Physiology

ABSTRACT

What is the central question of this study? What is the precise subcellular localization of the epithelial sodium channel (ENaC) in human airway epithelium? What is the main finding and its importance? ENaC protein has an unexpected localization in the peripheral region of the apical membrane of bronchial epithelial cells, very close to tight junctions. This may be important for the mechanism of Na+ absorption

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