Eating Rewards the Gears of the Clock.

Eating behavior is regulated by metabolic and hedonic brain networks, which interact with each other to balance the physiological regulation of hunger and satiety. The daily balance of this regulation is controlled by the central circadian clock. Importantly, metabolic and reward properties of food impact the functioning of circadian clocks, altering the oscillatory activity of the molecular clockwork and circadian rhythms. However, when feeding (metabolic or reward) is timed, the whole circadian system is entrained. Furthermore, besides synchronizing the clock, the timing of both metabolic and reward eating might be crucial for health, to improve circadian physiology, as well as to treat metabolic (e.g., diabetes, obesity) and neurological diseases (e.g., mental, neurodegenerative).

• Publication year

  2019

• Venue

  Trends in endocrinology and metabolism

• Publication date

  2019-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.tem.2019.03.001PMID 30935670
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Food intake and addictive-like eating behaviors: Time to think about the circadian clock(s).

  2019cited by this paper
• Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock.

  2019cited by this paper
• Overlapping Brain Circuits for Homeostatic and Hedonic Feeding.

  2018cited by this paper
• The suprachiasmatic nucleus.

  2018cited by this paper
• Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes.

  2018cited by this paper
• A suprachiasmatic-independent circadian clock(s) in the habenula is affected by Per gene mutations and housing light conditions in mice

  2018cited by this paper
• Ghrelin is Impacted by the Endogenous Circadian System and by Circadian Misalignment in Humans

  2018cited by this paper
• Circadian peak dopaminergic activity response at the biological clock pacemaker (suprachiasmatic nucleus) area mediates the metabolic responsiveness to a high‐fat diet

  2018cited by this paper
• Light rescues circadian behavior and brain dopamine abnormalities in diurnal rodents exposed to a winter-like photoperiod

  2018cited by this paper
• Circadian regulation of glucose, lipid, and energy metabolism in humans.

  2017cited by this paper
• Ventral tegmental area: cellular heterogeneity, connectivity and behaviour

  2017cited by this paper
• Timing of caloric intake during weight loss differentially affects striatal dopamine transporter and thalamic serotonin transporter binding

  2017cited by this paper
• Mood, the Circadian System, and Melanopsin Retinal Ganglion Cells.

  2017cited by this paper
• Effects of a free-choice high-fat high-sugar diet on brain PER2 and BMAL1 protein expression in mice.

  2017cited by this paper
• The dopamine motive system: implications for drug and food addiction

  2017cited by this paper
• The Lateral Habenula and Adaptive Behaviors.

  2017cited by this paper
• Circadian neurons in the lateral habenula: Clocking motivated behaviors

  2017cited by this paper
• Later circadian timing of food intake is associated with increased body fat.

  2017cited by this paper
• Rev‐erbα modulates the hypothalamic orexinergic system to influence pleasurable feeding behaviour in mice

  2017cited by this paper
• Circadian Biology: Uncoupling Human Body Clocks by Food Timing.

  2017cited by this paper
• Direct Midbrain Dopamine Input to the Suprachiasmatic Nucleus Accelerates Circadian Entrainment.

  2017cited by this paper
• Circadian rhythms of hedonic drinking behavior in mice.

  2017cited by this paper
• Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Regulate Feeding and Reward

  2016cited by this paper
• Sleep Deprivation Influences Circadian Gene Expression in the Lateral Habenula

  2016cited by this paper
• Dorsolateral neostriatum contribution to incentive salience: opioid or dopamine stimulation makes one reward cue more motivationally attractive than another

  2016cited by this paper
• Risk of obesity in male shift workers: A chronophysiological approach

  2016cited by this paper
• Period-independent novel circadian oscillators revealed by timed exercise and palatable meals

  2016cited by this paper
• Circadian Rhythms, Metabolism, and Chrononutrition in Rodents and Humans.

  2016cited by this paper
• Short sleep duration and dietary intake: epidemiologic evidence, mechanisms, and health implications.

  2015cited by this paper
• Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion

  2015cited by this paper
• A Smartphone App Reveals Erratic Diurnal Eating Patterns in Humans that Can Be Modulated for Health Benefits.

  2015cited by this paper
• Serotonin controlling feeding and satiety.

  2015cited by this paper
• Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol.

  2015cited by this paper
• Clock-Talk: Interactions between Central and Peripheral Circadian Oscillators in Mammals.

  2015cited by this paper
• Oxyntomodulin regulates resetting of the liver circadian clock by food

  2015cited by this paper
• SIRT1 Relays Nutritional Inputs to the Circadian Clock Through the Sf1 Neurons of the Ventromedial Hypothalamus.

  2015cited by this paper
• Influence of the Cardiomyocyte Circadian Clock on Cardiac Physiology and Pathophysiology

  2015cited by this paper
• Projections from the subparaventricular zone define four channels of output from the circadian timing system

  2015cited by this paper
• Coupling circadian rhythms of metabolism and chromatin remodelling

  2015cited by this paper
• Molecular components of the circadian clock in mammals

  2015cited by this paper
• Regulation of the mesolimbic dopamine circuit by feeding peptides.

  2015cited by this paper
• Acute Suppressive and Long-Term Phase Modulation Actions of Orexin on the Mammalian Circadian Clock

  2014cited by this paper
• Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges.

  2014cited by this paper
• The role of orexin in motivated behaviours

  2014cited by this paper
• Dopamine transporters govern diurnal variation in extracellular dopamine tone

  2014cited by this paper
• The snacking rat as model of human obesity: effects of a free-choice high-fat high-sugar diet on meal patterns

  2014cited by this paper
• Regulation of circadian rhythms in mammals by behavioral arousal.

  2014cited by this paper
• Meal timing affects glucose tolerance, substrate oxidation and circadian-related variables: A randomized, crossover trial

  2014cited by this paper
• Metabolic and neuropsychiatric effects of calorie restriction and sirtuins.

  2013cited by this paper
• Circadian adaptations to meal timing: neuroendocrine mechanisms

  2013cited by this paper
• Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet.

  2012cited by this paper
• Setting the main circadian clock of a diurnal mammal by hypocaloric feeding

  2012cited by this paper
• Timing to perfection: the biology of central and peripheral circadian clocks.

  2012cited by this paper
• Social jetlag and obesity.

  2012cited by this paper
• Autonomous and self-sustained circadian oscillators displayed in human islet cells

  2012cited by this paper
• Reward, dopamine and the control of food intake: implications for obesity.

  2011cited by this paper
• Melanopsin-Positive Intrinsically Photosensitive Retinal Ganglion Cells: From Form to Function

  2011cited by this paper
• Endogenous Dopamine Regulates the Rhythm of Expression of the Clock Protein PER2 in the Rat Dorsal Striatum via Daily Activation of D2 Dopamine Receptors

  2010cited by this paper
• Cannabinoids Excite Circadian Clock Neurons

  2010cited by this paper
• Circadian oscillators in the epithalamus

  2010cited by this paper
• Disruption of Peripheral Circadian Timekeeping in a Mouse Model of Huntington's Disease and Its Restoration by Temporally Scheduled Feeding

  2010cited by this paper
• Disruption of the Clock Components CLOCK and BMAL1 Leads to Hypoinsulinemia and Diabetes

  2010cited by this paper
• Food‐reward signalling in the suprachiasmatic clock

  2010cited by this paper
• Adverse metabolic and cardiovascular consequences of circadian misalignment

  2009cited by this paper
• Circuit projection from suprachiasmatic nucleus to ventral tegmental area: a novel circadian output pathway

  2009cited by this paper
• Circadian Timing of Food Intake Contributes to Weight Gain

  2009cited by this paper
• Food‐entrainable circadian oscillators in the brain

  2009cited by this paper
• Physiological significance of a peripheral tissue circadian clock

  2008cited by this paper
• High‐fat feeding alters the clock synchronization to light

  2008cited by this paper
• High-fat diet disrupts behavioral and molecular circadian rhythms in mice.

  2007cited by this paper
• Endocannabinoid Hedonic Hotspot for Sensory Pleasure: Anandamide in Nucleus Accumbens Shell Enhances ‘Liking’ of a Sweet Reward

  2007cited by this paper
• Entrainment to Feeding but Not to Light: Circadian Phenotype of VPAC2 Receptor-Null Mice

  2007cited by this paper
• Daily restricted feeding resets the circadian clock in the suprachiasmatic nucleus of CS mice.

  2007cited by this paper
• Ghrelin Effects on the Circadian System of Mice

  2007cited by this paper
• Circadian Clocks: Setting Time By Food

  2007cited by this paper
• Expression of ghrelin receptor mRNA in the rat and the mouse brain

  2006cited by this paper
• The opioid fentanyl affects light input, electrical activity and Per gene expression in the hamster suprachiasmatic nuclei

  2005cited by this paper
• Feeding Cues Alter Clock Gene Oscillations and Photic Responses in the Suprachiasmatic Nuclei of Mice Exposed to a Light/Dark Cycle

  2005cited by this paper
• A daily palatable meal without food deprivation entrains the suprachiasmatic nucleus of rats

  2005cited by this paper
• The Suprachiasmatic Nucleus Entrains, But Does Not Sustain, Circadian Rhythmicity in the Olfactory Bulb

  2004cited by this paper
• Convergence of circadian and sleep regulatory mechanisms on hypocretin-1.

  2004cited by this paper
• Cardiovascular Control by the Suprachiasmatic Nucleus: Neural and Neuroendocrine Mechanisms in Human and Rat

  2003cited by this paper
• Leptin phase-advances the rat suprachiasmatic circadian clock in vitro.

  2003cited by this paper
• Entrainment of the circadian clock in the liver by feeding.

  2001cited by this paper
• Involvement of the MAP kinase cascade in resetting of the mammalian circadian clock.

  2000cited by this paper
• Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus.

  2000cited by this paper
• Resetting central and peripheral circadian oscillators in transgenic rats.

  2000cited by this paper
• Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus

  1998cited by this paper
• Expression of the liver-enriched transcriptional activator protein DBP follows a stringent circadian rhythm.

  1990cited by this paper
• Circadian rhythms of the spontaneous meal pattern, macronutrient intake, and mood of humans.

  1987cited by this paper
• Circadian rhythms for food and water consumption in the mouse, Mus musculus.

  1979cited by this paper
• This Work Is Licensed under a Creative Commons Attribution 2.0 Generic License a Riot of Rhythms: Neuronal and Glial Circadian Oscillators in the Mediobasal Hypothalamus

  year unknowncited by this paper

• Brain circadian clocks timing the 24h rhythms of behavior

  2025cites this paper
• The significance of high sensitivity in shaping abnormal eating behaviors in young adult women 1

  2023cites this paper
• Restricting feeding to dark phase fails to entrain circadian activity and energy expenditure oscillations in Pitx3-mutant Aphakia mice.

  2022cites this paper
• Chronobiology Meets Quantum Biology: A New Paradigm Overlooking the Horizon?

  2022cites this paper
• Dopamine systems and biological rhythms: Let’s get a move on

  2022cites this paper
• Suprachiasmatic to paraventricular nuclei interaction generates normal food searching rhythms in mice

  2022cites this paper
• Food reward induction of rhythmic clock gene expression in the prefrontal cortex of rats is accompanied by changes in miR‐34a‐5p expression

  2021influential citation
• Dopamine Signaling in the Suprachiasmatic Nucleus Enables Weight Gain Associated with Hedonic Feeding.

  2020cites this paper
• Hypothalamic neuronal cellular and subcellular abnormalities in experimental obesity

  2019cites this paper
• Dopamine Signaling in the Suprachiasmatic Nucleus Enables Weight Gain Associated with Hedonic Feeding.

  2019cites this paper
• Automatic control of Hypothalamus-Pituitary-Adrenal axis dynamics

  2019cites this paper