Trans fat feeding results in higher serum alanine aminotransferase and increased insulin resistance compared with a standard murine high-fat diet.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  American Journal of Physiology - Gastrointestinal and Liver Physiology

• Publication date

  2009-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpgi.90543.2008PMID 19541924PMCID PMC2724085
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of Interleukin-6-induced Hepatic Insulin Resistance by Mammalian Target of Rapamycin through the STAT3-SOCS3 Pathway*

  2008cited by this paper
• Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet

  2008cited by this paper
• Hydrogenated fat intake during pregnancy and lactation modifies serum lipid profile and adipokine mRNA in 21-day-old rats.

  2008cited by this paper
• The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia.

  2008cited by this paper
• Diet and nonalcoholic fatty liver disease

  2008cited by this paper
• Non-alcoholic fatty liver disease and the metabolic syndrome: an update.

  2008cited by this paper
• Interleukin-10 is a protective factor against diet-induced insulin resistance in liver.

  2008cited by this paper
• Interleukin-1-receptor antagonist in type 2 diabetes mellitus.

  2007cited by this paper
• Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease.

  2007cited by this paper
• Interleukin1beta genetic polymorphisms interact with polyunsaturated fatty acids to modulate risk of the metabolic syndrome.

  2007cited by this paper
• Interleukin1β Genetic Polymorphisms Interact with Polyunsaturated Fatty Acids to Modulate Risk of the Metabolic Syndrome

  2007cited by this paper
• Association between nonalcoholic fatty liver disease and coronary artery disease

  2007cited by this paper
• Post-load insulin resistance is an independent predictor of hepatic fibrosis in virus C chronic hepatitis and in non-alcoholic fatty liver disease

  2007cited by this paper
• Hormonal Responses to a Fast-Food Meal Compared with Nutritionally Comparable Meals of Different Composition

  2007cited by this paper
• Genetic association of interleukin-1β (-511C/T) and interleukin-1 receptor antagonist (86 bp repeat) polymorphisms with Type 2 diabetes mellitus in North Indians

  2007cited by this paper
• Prevalence of Nonalcoholic Fatty Liver Disease and Its Association With Cardiovascular Disease Among Type 2 Diabetic Patients

  2007cited by this paper
• Interleukin-1-receptor antagonist in type 2 diabetes mellitus.

  2007cited by this paper
• The Epidemiology of Nonalcoholic Fatty Liver Disease in Adults

  2006cited by this paper
• Trans fatty acids and cardiovascular disease.

  2006cited by this paper
• Elevated serum alanine aminotransferase activity and calculated risk of coronary heart disease in the United States

  2006cited by this paper
• Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes

  2006cited by this paper
• Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients.

  2005cited by this paper
• Dietary trans-fatty acids alter adipocyte plasma membrane fatty acid composition and insulin sensitivity in rats.

  2005cited by this paper
• Comparison of the acute response to meals enriched with cis- or trans-fatty acids on glucose and lipids in overweight individuals with differing FABP2 genotypes.

  2005cited by this paper
• Interleukin-6 depletion selectively improves hepatic insulin action in obesity.

  2005cited by this paper
• Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction.

  2005cited by this paper
• Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the nurses' health study.

  2005cited by this paper
• Abnormal glucose tolerance is a predictor of steatohepatitis and fibrosis in patients with non-alcoholic fatty liver disease

  2005cited by this paper
• Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse.

  2004cited by this paper
• Comparison of cis and trans fatty acid containing phosphatidylcholines on membrane properties.

  2004cited by this paper
• Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials.

  2003cited by this paper
• Trends in the trans-fatty acid composition of the diet in a metropolitan area: the Minnesota Heart Survey.

  2003cited by this paper
• Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome

  2003cited by this paper
• Dietary fat and meat intake in relation to risk of type 2 diabetes in men.

  2002cited by this paper
• Interleukin-6 induces cellular insulin resistance in hepatocytes.

  2002cited by this paper
• Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets.

  2002cited by this paper
• Effects of diets enriched in saturated (palmitic), monounsaturated (oleic), or trans (elaidic) fatty acids on insulin sensitivity and substrate oxidation in healthy adults.

  2002cited by this paper
• Dietary Patterns and Risk for Type 2 Diabetes Mellitus in U.S. Men

  2002cited by this paper
• DIET , LIFESTYLE , AND THE RISK OF TYPE 2 DIABETES MELLITUS IN WOMEN

  2001cited by this paper
• Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese.

  2001cited by this paper
• Association between trans fatty acid intake and 10-year risk of coronary heart disease in the Zutphen Elderly Study: a prospective population-based study.

  2001cited by this paper
• Replacement of Dietary Saturated Fatty Acids by Trans Fatty Acids Lowers Serum HDL Cholesterol and Impairs Endothelial Function in Healthy Men and Women

  2001cited by this paper
• Diet, lifestyle, and the risk of type 2 diabetes mellitus in women.

  2001cited by this paper
• Dietary fat intake and risk of type 2 diabetes in women.

  2001cited by this paper
• Dietary fat and incidence of type 2 diabetes in older Iowa women.

  2001cited by this paper
• Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo.

  2001cited by this paper
• Diet and risk of Type II diabetes: the role of types of fat and carbohydrate

  2001cited by this paper
• Estimated intakes of trans fatty and other fatty acids in the US population.

  1999cited by this paper
• Differential effects of cis and trans fatty acids on insulin release from isolated mouse islets.

  1999cited by this paper
• A high-trans fatty acid diet and insulin sensitivity in young healthy women.

  1999cited by this paper
• Intake of a Diet High in Trans Monounsaturated Fatty Acids or Saturated Fatty Acids: Effects on postprandial insulinemia and glycemia in obese patients with NIDDM

  1997cited by this paper
• Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States

  1996cited by this paper
• Transient increase in obese gene expression after food intake or insulin administration

  1995cited by this paper
• Effects of systemic infusions of endotoxin, tumor necrosis factor, and interleukin-1 on glucose metabolism in the rat: relationship to endogenous glucose production and peripheral tissue glucose uptake.

  1994cited by this paper
• Interleukin-1 (cid:1) -Induced Insulin Resistance in Adipocytes through Down-Regulation of Insulin Receptor Substrate-1 Expression

  year unknowncited by this paper

• Unveiling MASH: A Comprehensive Review Highlighting Experimental Insights, Molecular Pathogenesis, and Therapeutic Approaches.

  2026cites this paper
• Sugars and Sweetness

  2025cites this paper
• Hidden Industrial Trans-Fatty Acids: Mechanistic Insights into Dyslipidemia, Cardiovascular Disease, and Metabolic Dysfunction-Associated Steatotic Liver Disease

  2025cites this paper
• Effects of beef fat enriched with trans vaccenic acid and cis9, trans11-CLA on glucose homoeostasis and hepatic lipid accumulation in high-fat diet-induced obese mice

  2024influential citation
• Increased expression of sodium-glucose cotransporter 2 and O-GlcNAcylation in hepatocytes drives non-alcoholic steatohepatitis.

  2023cites this paper
• The Pathogenesis of HCC Driven by NASH and the Preventive and Therapeutic Effects of Natural Products

  2022cites this paper
• A high-fat, high-fructose diet induced hepatic steatosis, renal lesions, dyslipidemia, and hyperuricemia in non-obese rats

  2022cites this paper
• Ultrasound biomicroscopy for the assessment of early-stage nonalcoholic fatty liver disease induced in rats by a high-fat diet

  2022cites this paper
• Diet-Induced Models of Non-Alcoholic Fatty Liver Disease: Food for Thought on Sugar, Fat, and Cholesterol

  2021cites this paper
• Effects of trans-Fatty Acid on Lipoproteins-a, Oxidative Status and Expression of Leptin and Leptin Receptor Genes in Albino Rats

  2021cites this paper
• Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship

  2021cites this paper
• Diet Significantly Influences the Immunopathology and Severity of Kidney Injury in Male C57Bl/6J Mice in a Model Dependent Manner

  2021cites this paper
• Addition of trans-fat and alcohol has divergent effects on atherogenic diet-induced liver injury in rodent models of steatohepatitis.

  2020cites this paper
• Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments

  2020cites this paper
• Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source

  2019cites this paper
• Mechanisms of Action of trans Fatty Acids

  2019cites this paper
• Partially hydrogenated vegetable oil containing 5% trans fats when combined with fructose exacerbates obesity and non-alcoholic fatty liver disease in rats

  2019cites this paper
• Trans Fats and Metabolic Syndrome

  2019cites this paper
• Current Models of Fatty Liver Disease; New Insights, Therapeutic Targets and Interventions.

  2019cites this paper
• Hydrogenated Vegetable Oils and Trans Fatty Acids: Profile and Application to Diabetes

  2019cites this paper
• Some biochemical studies on trans fatty acid-containing diet.

  2019cites this paper
• Industrial Trans Fatty Acids Stimulate SREBP2‐Mediated Cholesterogenesis and Promote Non‐Alcoholic Fatty Liver Disease

  2019cites this paper
• Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease

  2019cites this paper
• Link between plasma trans-fatty acid and fatty liver is moderated by adiposity.

  2018cites this paper
• The main approaches to dietary changes in non-alcoholic fatty liver disease

  2018cites this paper
• PENGARUH PEMBERIAN TRANS FATTY ACID

  2017cites this paper
• Animal Models of Nonalcoholic Fatty Liver Disease—A Starter’s Guide

  2017influential citation
• Effect of a trans fatty acid-enriched diet on biochemical and inflammatory parameters in Wistar rats

  2017cites this paper
• Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD

  2015cites this paper
• Weight Gain and Blood Glucose Level in Granting Trans Fatty Acids (Study at Sprague Dawley)

  2015cites this paper
• High Fatty Diet Effects on Rat Liver

  2014cites this paper
• Obesity and the liver: nonalcoholic fatty liver disease.

  2014cites this paper
• Nutritional Induction of Nonalcoholic Fatty Liver Disease

  2014cites this paper
• Loss of 5α-Reductase Type 1 Accelerates the Development of Hepatic Steatosis but Protects Against Hepatocellular Carcinoma in Male Mice

  2013cites this paper
• Effects of Trans-Fatty Acids on Liver Lipid Metabolism in Mice Fed on Diets Showing Different Fatty Acid Composition

  2013cites this paper
• Nonalcoholic fatty liver disease: a nutritional approach.

  2012cites this paper
• Dietary trans-Fatty Acid Induced NASH is Normalized Following Loss of trans-Fatty Acids from Hepatic Lipid Pools

  2012cites this paper
• Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease

  2012cites this paper
• Improving dietary patterns in patients with nonalcoholic fatty liver disease

  2012cites this paper
• Role of renin angiotensin system and its inhibition by perindopril and irbesartan in non alcoholic steatohepatitis induced experimentally in rats

  2012cites this paper
• Trans fatty acids and weight gain

  2011cites this paper
• INVITED REVIEW Trans fatty acids, insulin resistance and diabetes

  2011cites this paper
• Trans fatty acids, insulin resistance and diabetes

  2011cites this paper
• Effect of trans-fat, fructose and monosodium glutamate feeding on feline weight gain, adiposity, insulin sensitivity, adipokine and lipid profile

  2011cites this paper
• Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet.

  2011cites this paper
• Effect of trans fatty acid intake on abdominal and liver fat deposition and blood lipids: a randomized trial in overweight postmenopausal women

  2011cites this paper
• General Nutritional Guidelines for Liver Disease, Cirrhosis, and Its Complications

  2011cites this paper
• New Insights from Rodent Models of Fatty Liver Disease

  2011cites this paper
• Nonalcoholic fatty liver disease: a review of the spectrum of disease, diagnosis, and therapy.

  2011cites this paper
• Implications of diet on nonalcoholic fatty liver disease

  2010cites this paper
• Nutritional Recommendations for Patients with Non-Alcoholic Fatty Liver Disease : An Evidence Based Review

  2010influential citation
• Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice.

  2010influential citation
• Non‐alcoholic fatty liver disease from pathogenesis to management: an update

  2009cites this paper
• Trans-fatty acids and nonlipid risk factors

  2009cites this paper