Superior T-cell suppression by rapamycin and FK506 over rapamycin and cyclosporine A because of abrogated cytotoxic T-lymphocyte induction, impaired memory responses, and persistent apoptosis

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Transplantation

• Publication date

  2003-05-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/01.TP.0000053752.87383.67PMID 12792519
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• T cell death and transplantation tolerance.

  2001cited by this paper
• Activation-induced cell death.

  2001cited by this paper
• CD4+ T cell effectors can become memory cells with high efficiency and without further division

  2001cited by this paper
• Blockade of CD86 and CD40 induces alloantigen-specific immunoregulatory T cells that remain anergic even after reversal of hyporesponsiveness.

  2000cited by this paper
• Response of naïve and memory CD8+ T cells to antigen stimulation in vivo

  2000cited by this paper
• Sirolimus-tacrolimus combination immunosuppression.

  2000cited by this paper
• Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study. The Rapamune US Study Group.

  2000cited by this paper
• Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study

  2000cited by this paper
• Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.

  2000cited by this paper
• Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

  2000cited by this paper
• Manipulating immune responses with immunosuppressive agents that target NFAT.

  2000cited by this paper
• Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation.

  1999cited by this paper
• Induction of allograft tolerance in the absence of Fas-mediated apoptosis.

  1999cited by this paper
• Immunosuppressive effects and safety of a sirolimus/cyclosporine combination regimen for renal transplantation.

  1999cited by this paper
• Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

  1999cited by this paper
• Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

  1999cited by this paper
• Immunosuppressive strategies in transplantation.

  1999cited by this paper
• The Bcl-2 protein family: arbiters of cell survival.

  1998cited by this paper
• Cutting Edge Commentary: Differential TCR Signaling and the Generation of Memory T Cells

  1998cited by this paper
• T cell memory.

  1998cited by this paper
• Homeostasis and self-tolerance in the immune system: turning lymphocytes off.

  1998cited by this paper
• Effect of tacrolimus (FK506) and sirolimus (rapamycin) mono- and combination therapy in prolongation of renal allograft survival in the monkey.

  1998cited by this paper
• Differential TCR signaling and the generation of memory T cells.

  1998cited by this paper
• Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression.

  1998cited by this paper
• Differential regulation of T cell activation for primary versus secondary proliferative responses.

  1997cited by this paper
• Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

  1997cited by this paper
• Tacrolimus (FK506) and sirolimus (rapamycin) in combination are not antagonistic but produce extended graft survival in cardiac transplantation in the rat.

  1997cited by this paper
• The regulation of p27Kip1 expression following the polyclonal activation of murine G0 T cells.

  1997cited by this paper
• Immunopharmacology of rapamycin.

  1996cited by this paper
• Immunological Memory and Protective Immunity: Understanding Their Relation

  1996cited by this paper
• Kinetics of in vitro immune responses of T and B cells during tolerance induction by sirolimus.

  1996cited by this paper
• Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain.

  1996cited by this paper
• The mechanism of action of cyclosporin A and FK506.

  1996cited by this paper
• Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.

  1996influential reference
• Cyclosporin A blocks apoptosis by inhibiting the DNA binding activity of the transcription factor Nur77.

  1995cited by this paper
• Interleukin‐2 down‐modulates memory T helper lymphocyte development during antigenic stimulation in vitro

  1995cited by this paper
• lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

  1994cited by this paper
• Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1

  1993cited by this paper
• Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology.

  1993cited by this paper
• The mechanism of action of cyclosporin A and FK506.

  1992cited by this paper
• The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin

  1992cited by this paper
• Synergistic interactions of cyclosporine and rapamycin to inhibit immune performances of normal human peripheral blood lymphocytes in vitro.

  1991influential reference
• The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.

  1990cited by this paper
• Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

  1990cited by this paper
• A cell culture model for T lymphocyte clonal anergy.

  1990cited by this paper
• Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

  1989cited by this paper

• Acute Graft-Versus-Host Disease, Prophylaxis and Therapy

  2021cites this paper
• Immunology of the uterine mucosae

  2020cites this paper
• Effects of Immunosuppressive Medications on Mitochondrial Function.

  2020cites this paper
• From risk indices to reconstitution of immunity : studies of outcome-related factors in patients undergoing allogeneic hematopoietic stem cell transplantation

  2019cites this paper
• A monocentric study of steroid-refractory acute graft-versus-host disease treatment with tacrolimus and mTOR inhibitor

  2019cites this paper
• Selective Effects of mTOR Inhibitor Sirolimus on Naïve and CMV-Specific T Cells Extending Its Applicable Range Beyond Immunosuppression

  2018cites this paper
• A Time-to-Event Model for Acute Kidney Injury after Reduced-Intensity Conditioning Stem Cell Transplantation Using a Tacrolimus- and Sirolimus-based Graft-versus-Host Disease Prophylaxis.

  2017cites this paper
• Inhibition of miR-202 sensitizes Jurkat human T lymphocytes to tacrolimus through upregulation of hexokinase 2

  2017influential citation
• Stabilizing human regulatory T cells for tolerance inducing immunotherapy.

  2017cites this paper
• Involvement of indirectly allostimulated CD4+CD43highCD45RO+ T cell proliferation in the development of chronic allograft nephropathy

  2016cites this paper
• A prospective randomized trial comparing cyclosporine/methotrexate and tacrolimus/sirolimus as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation

  2016cites this paper
• Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics of Immunosuppressants in Allogeneic Hematopoietic Cell Transplantation: Part II

  2016cites this paper
• Sirolimus, tacrolimus and low-dose methotrexate based graft-versus-host disease prophylaxis after non-ablative or reduced intensity conditioning in related and unrelated donor allogeneic hematopoietic cell transplant

  2015cites this paper
• Introduction of a Framework for Dynamic Knowledge Representation of the Control Structure of Transplant Immunology: Employing the Power of Abstraction with a Solid Organ Transplant Agent-Based Model

  2015cites this paper
• De novo alloreactive memory CD8+ T cells develop following allogeneic challenge when CNI immunosuppression is delayed.

  2015cites this paper
• Substantial Proliferation of Human Renal Tubular Epithelial Cell–Reactive CD4+CD28null Memory T Cells, Which Is Resistant to Tacrolimus and Everolimus

  2014cites this paper
• Longitudinal Analysis of T and B Cell Phenotype and Function in Renal Transplant Recipients with or without Rituximab Induction Therapy

  2014cites this paper
• CD8+ T CELLS IN THE DEVELOPMENT OF ALLOGRAFT VASCULOPATHY AND DE NOVO ALLOSPECIFIC MEMORY FORMATION

  2014cites this paper
• Human Tubular Epithelial Cells and T-cell Alloreactivity

  2014cites this paper
• Defining the role of sirolimus in the management of graft-versus-host disease: from prophylaxis to treatment.

  2013cites this paper
• Greater Efficacy of Tolerance Induction with Cyclosporine versus Tacrolimus in Composite Tissue Allotransplants with Less Myeloablative Conditioning

  2011cites this paper
• Sirolimus and tacrolimus as immune prophylaxis compared to cyclosporine with or without methotrexate in patients undergoing allogeneic haematopoietic stem cell transplantation for non‐malignant disorders

  2011cites this paper
• Acute Graft Versus Host Disease: Prophylaxis

  2010cites this paper
• Rapamycin or tacrolimus alone fails to resist cardiac allograft accelerated rejection mediated by alloreactive CD4(+) memory T cells in mice.

  2010cites this paper
• Should methotrexate plus calcineurin inhibitors be considered standard of care for prophylaxis of acute graft-versus-host disease?

  2010cites this paper
• Sirolimus immunosuppression for graft-versus-host disease prophylaxis and therapy: an update

  2010cites this paper
• Endogenous remyelination is induced by transplant rejection in a viral model of multiple sclerosis.

  2009cites this paper
• Novel drugs for the prevention and treatment of acute GVHD.

  2008cites this paper
• Sirolimus in combination with tacrolimus in allogeneic stem cell transplantation--timing and conditioning regimen may be crucial.

  2008cites this paper
• Rapamycin-induced cytotoxic signal transduction pathway.

  2008cites this paper
• Current and future approaches for control of graft-versus-host disease

  2008cites this paper
• Generation, homeostasis, and regulation of memory T cells in transplantation

  2007cites this paper
• Reshaping the past: Strategies for modulating T-cell memory immune responses.

  2007cites this paper
• The Cairo kidney center protocol for rapamycin-based sequential immunosuppression in kidney transplant recipients: 2-year outcomes.

  2007cites this paper
• Nonallergic eosinophilic conjunctivitis

  2007cites this paper
• Effects of different immunosuppressive regimens on regulatory T‐cells in noninflamed colon of liver transplant recipients

  2007cites this paper
• Combined Low Dose Cyclosporine and Prednisone Down-Regulate Natural Killer Cell-Like Effector Functions of CD8brightCD56+ T Cells in Patients with Active Behçet Uveitis

  2006cites this paper
• Relevance of Posttransplant Flow Cytometric T- and B-cell Crossmatches in Tacrolimus-Treated Renal Transplant Patients

  2006cites this paper
• Rapamycin Does Not Induce Anergy but Inhibits Expansion and Differentiation of Alloreactive Human T Cells

  2006cites this paper
• Recipient Memory-Like Lymphocytes Remain Unresponsive to Graft Antigens After CAMPATH-1H Induction with Reduced Maintenance Immunosuppression

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• Antigen-specific regulatory T-cell subsets in transplantation tolerance regulatory T-cell subset quality reduces the need for quantity.

  2006cites this paper
• Immunization with an adjuvant hepatitis B vaccine in liver transplant recipients: Antibody decline and booster vaccination with conventional vaccine

  2006cites this paper
• Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells.

  2006cites this paper
• Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

  2005cites this paper
• Reepithelialized Orthotopic Tracheal Allografts Expand Memory Cytotoxic T Lymphocytes But Show No Evidence of Chronic Rejection

  2005cites this paper
• Augmentation of Type-1 Polarizing Ability of Monocyte-Derived Dendritic Cells from Chronically Immunosuppressed Organ-Transplant Recipients

  2005cites this paper
• Cyclosporine Preserves the Anergic State of Human T Cells Induced by Costimulation Blockade In Vitro

  2005cites this paper
• Cutaneous Adverse Events in Renal Transplant Recipients Receiving Sirolimus-Based Therapy1

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• UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL FACULDADE DE MEDICINA PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS MÉDICAS: NEFROLOGIA

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  2004influential citation
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  2003cites this paper