Impact of G. applanatum, a multifunctional herbal extract on haematological profiles of laboratory rats: a preliminary study in Nigeria

Abstract Objective To ascertain the haematological properties of aqueous extract of G. applanatum(G. applanatum). Methods Sixty albino rats were grouped into six equal groups (10 each) from A to F, consisting of tests and controls. Laboratory albino rats in groups A, B and C were infected with Trypanosoma brucei (T. brucei) while groups A and B (Test) were treated with aqueous G. applanatum extract; other groups served as control. Microscopy and haematological profiles from the albino rats were monitored on daily basis for blood parasites, Packed Cell Volume (PCV), Haemoglobin Concentration (HC), Total Red Blood Cell Count (RBC), Mean Cell Haemoglobin (MCH), Mean Cell Volume (MCV), Mean Cell Haemoglobin Concentration (MCHC), and Total White Blood Cell Count (WBC). Results Albino rats in groups A, B and C infected with T. brucei and treated with various concentrations of aqueous G. applanatum showed a progressive reduction in PCV, HC, RBC, MCH and MCHC compared to the controls (P Conclusions G. applanatum lacks ability to boost haematological profiles of anaemic laboratory rats and also of no use in the treatment of African Trypanosomiasis. Higher doses of the fungal extract may be required to test on laboratory rats with less lethal biological stimulants of anaemia before proving or otherwise its true haematological properties.

• Publication year

  2012

• Venue

  Asian Pacific Journal of Tropical Disease

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/S2222-1808(12)60165-0
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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