Preferential formation of deletions following in vivo exposure of postmeiotic Drosophila germ cells to the DNA etheno‐adduct‐forming carcinogen vinyl carbamate

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Environmental and Molecular Mutagenesis

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1002/(SICI)1098-2280(1997)30:3<321::AID-EM11>3.0.CO;2-FPMID 9366911
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Copper-dependent formation of miscoding etheno-DNA adducts in the liver of Long Evans cinnamon (LEC) rats developing hereditary hepatitis and hepatocellular carcinoma.

  1996cited by this paper
• 1,N6-ethenodeoxyadenosine, a DNA adduct highly mutagenic in mammalian cells.

  1996cited by this paper
• Formation and accumulation of DNA ethenobases in adult Sprague-Dawley rats exposed to vinyl chloride.

  1996cited by this paper
• Mutational spectra induced under distinct excision repair conditions by the 3 methylating agents N-methyl-N-nitrosourea, N-methyl-N'-nitro-N-nitrosoguanidine and N-nitrosodimethylamine in postmeiotic male germ cells of Drosophila.

  1996cited by this paper
• Characterization by two-endpoint comparisons of the genetic toxicity profiles of vinyl chloride and related etheno-adduct forming carcinogens in Drosophila.

  1996cited by this paper
• Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts.

  1996cited by this paper
• Formation of 1,N6-ethenoadenine and 3,N4-ethenocytosine by lipid peroxidation products and nucleic acid bases.

  1995cited by this paper
• The cross-linking agent hexamethylphosphoramide predominantly induces intra-locus and multi-locus deletions in postmeiotic germ cells of Drosophila.

  1995cited by this paper
• 1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytine in liver DNA from humans and untreated rodents detected by immunoaffinity/32P-postlabeling.

  1995cited by this paper
• Molecular analysis of mutations induced by 2-chloroacetaldehyde, the ultimate carcinogenic form of vinyl chloride, in human cells using shuttle vectors.

  1995cited by this paper
• Hexamethylmelamine is a potent inducer of deletions in male germ cells of Drosophila melanogaster.

  1995cited by this paper
• DNA damage and repair in somatic and germ cells in vivo.

  1995cited by this paper
• p53 mutations in primary hepatic angiosarcomas not associated with vinyl chloride exposure.

  1995cited by this paper
• Formation, detection, and role in carcinogenesis of ethenobases in DNA.

  1994cited by this paper
• Mutation spectra of 1,2-dibromoethane, 1,2-dichloroethane and 1-bromo-2-chloroethane in excision repair proficient and repair deficient strains of Drosophila melanogaster.

  1994cited by this paper
• p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers.

  1994cited by this paper
• Deletions induced in the white and vermilion genes of Drosophila melanogaster by the antitumor drug cis-dichlorodiammineplatinum(II).

  1994cited by this paper
• Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells.

  1994cited by this paper
• Mutagenic specificity of chemical carcinogens as determined by studies of single DNA adducts.

  1994cited by this paper
• Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole.

  1993cited by this paper
• Impact of DNA nucleotide excision repair on methyl methanesulfonate-induced mutations in Drosophila melanogaster.

  1993cited by this paper
• Performance of 181 chemicals in a Drosophila assay predominantly monitoring interchromosomal mitotic recombination.

  1993cited by this paper
• Quantitative multiplex sequence analysis of mutational hot spots. Frequency and specificity of mutations induced by a site-specific ethenocytosine in M13 viral DNA.

  1993cited by this paper
• Comparison of Ki-ras gene mutation among simultaneously occurring multiple urethan-induced lung tumors in individual mice.

  1992cited by this paper
• Etheno adducts formed in DNA of vinyl chloride-exposed rats are highly persistent in liver.

  1992cited by this paper
• Molecular analysis of mutations induced in the vermilion gene of Drosophila melanogaster by methyl methanesulfonate.

  1992cited by this paper
• Mutational specificity of ethyl methanesulfonate in excision-repair-proficient and -deficient strains of Drosophila melanogaster

  1991cited by this paper
• Evidence for the mutagenic potential of the vinyl chloride induced adduct, N2, 3-etheno-deoxyguanosine, using a site-directed kinetic assay.

  1991cited by this paper
• Enzymatic oxidation of ethyl carbamate to vinyl carbamate and its role as an intermediate in the formation of 1,N6-ethenoadenosine.

  1991cited by this paper
• The vinyl chloride DNA derivative N2,3-ethenoguanine produces G----A transitions in Escherichia coli.

  1991cited by this paper
• Mechanisms of mutagenesis by exocyclic DNA adducts. Transfection of M13 viral DNA bearing a site-specific adduct shows that ethenocytosine is a highly efficient RecA-independent mutagenic noninstructional lesion.

  1991cited by this paper
• 1,N6-ethenoadenosine formation, mutagenicity and murine tumor induction as indicators of the generation of an electrophilic epoxide metabolite of the closely related carcinogens ethyl carbamate (urethane) and vinyl carbamate.

  1990cited by this paper
• Synthesis and properties of vinyl carbamate epoxide, a possible ultimate electrophilic and carcinogenic metabolite of vinyl carbamate and ethyl carbamate.

  1990cited by this paper
• Vinyl chloride-induced DNA adducts. II: Formation and persistence of 7-(2'-oxoethyl)guanine and N2,3-ethenoguanine in rat tissue DNA.

  1990cited by this paper
• Molecular analysis of hprt mutants induced by 2-cyanoethylene oxide in human lymphoblastoid cells.

  1990cited by this paper
• 1,N6 Ethenoadenosine formation, mutagenicity and murine tumor induction as indicators of the generation of an electro philic epoxide metabolite of the closely related carcinogens ethyl carbamate (urethane) and vinyl carbamate

  1990cited by this paper
• 1,N6-etheno-2'-deoxyadenosine and 3,N4-etheno-2'-deoxycytidine detected by monoclonal antibodies in lung and liver DNA of rats exposed to vinyl chloride.

  1989cited by this paper
• Sequence analysis of N-ethyl-N-nitrosourea-induced vermilion mutations in Drosophila melanogaster.

  1989cited by this paper
• Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse.

  1989cited by this paper
• Nucleophilic selectivity of carcinogens as a determinant of enhanced mutational response in excision repair-defective strains in Drosophila: effects of 30 carcinogens.

  1989cited by this paper
• Dosage-response relationships for methyl methanesulfonate in Drosophila melanogaster spermatozoa: DNA methylation per nucleotide vs. sex-linked recessive lethal frequency.

  1989cited by this paper
• Pathways of human cell post-replication repair.

  1989cited by this paper
• Formation of interstrand cross-links in chloroacetaldehyde-treated DNA demonstrated by ethidium bromide fluorescence.

  1988cited by this paper
• The vinyl chloride-derived nucleoside, N2,3-ethenoguanosine, is a highly efficient mutagen in transcription.

  1987cited by this paper
• The role of cyclic base adducts in vinyl-chloride-induced carcinogenesis: studies on nucleic acid alkylation in vivo.

  1986cited by this paper
• Mutagenic and promutagenic properties of DNA adducts formed by vinyl chloride metabolites.

  1986cited by this paper
• Lack of miscoding properties of 7-(2-oxoethyl)guanine, the major vinyl chloride-DNA adduct.

  1985cited by this paper
• Assessment of mutagenic efficiency of two carcinogen-modified nucleosides, 1,N6-ethenodeoxyadenosine and O4-methyldeoxythymidine, using polymerases of varying fidelity.

  1984cited by this paper
• Labeled 1,N6-ethenoadenosine and 3,N4-ethenocytidine in hepatic RNA of mice given[ethyl-1,2(-3)H or ethyl-1(-14)C]ethyl carbamate (urethan).

  1982cited by this paper
• Studies on the miscoding properties of 1,N6-ethenoadenine and 3,N4-ethenocytosine, DNA reaction products of vinyl chloride metabolites, during in vitro DNA synthesis.

  1981cited by this paper
• The induction of errors during in vitro DNA synthesis following chloroacetaldehyde-treatment of poly(dA-dT) and poly(dC-dG) templates.

  1981cited by this paper
• How many loci on the X-chromosome of Drosophila melanogaster can mutate to recessive lethals?

  1980cited by this paper
• Alkylation of RNA by vinyl chloride metabolites in vitro and in vivo: formation of 1-N(6)-etheno-adenosine.

  1977cited by this paper

• The v 24 Allele is a Missense Mutation Within the Predicted Tryptophan 2,3-dioxygenase Protein Domain of vermilion

  2025cites this paper
• Recherche d’une éventuelle association entre les polymorphismes génétiques cytochrome P4501A1*2C, glutathion-S-transférase M1 null et le cancer du poumon chez une population Tunisienne

  2013cites this paper
• Carcinogen-specific targeting of chromosome 12 for loss of heterozygosity in mouse lung adenocarcinomas: implications for chromosome instability and tumor progression

  2004cites this paper
• Role of nucleotide- and base-excision repair in genotoxin-induced neuronal cell death.

  2004cites this paper
• Carcinogenic induction directs the selection of allelic losses in mouse lung tumorigenesis.

  2002cites this paper
• Etheno-adduct-forming chemicals: from mutagenicity testing to tumor mutation spectra.

  2000cites this paper
• Genetic effects of exocyclic DNA adducts in vivo: heritable genetic damage in comparison with loss of heterozygosity in somatic cells.

  1999cites this paper
• Evaluation of the database on mutant frequencies and DNA sequence alterations of vermilion mutations induced in germ cells of Drosophila shows the importance of a neutral mutation detection system.

  1999cites this paper
• Germ cell mutagenesis in Drosophila: multiple endpoint analysis.

  1998cites this paper