N-valproyl-L-phenylalanine as new potential antiepileptic drug: synthesis, characterization and in vitro studies on stability, toxicity and anticonvulsant efficacy.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Medicinal chemistry

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.2174/1573406410666140507094954PMID 24813685
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Primary cultured astrocytes from old rats are capable to activate the Nrf2 response against MPP+ toxicity after tBHQ pretreatment.

  2014cited by this paper
• Medicinal Chemistry Based Approaches and Nanotechnology‐Based Systems to Improve CNS Drug Targeting and Delivery

  2013cited by this paper
• Buccal delivery of methimazole as an alternative means for improvement of drug bioavailability: permeation studies and matrix system design.

  2012cited by this paper
• Inhibitory effects of N-valproyl-l-tryptophan on high potassium, low calcium and low magnesium-induced CA1 hippocampal epileptiform bursting activity in rat brain slices

  2012cited by this paper
• Prodrugs - an efficient way to breach delivery and targeting barriers.

  2011cited by this paper
• N-valproyl-L-tryptophan for CNS-targeting: synthesis, characterization and efficacy in vitro studies of a new potential antiepileptic drug.

  2011cited by this paper
• Valproic acid: Second generation

  2011cited by this paper
• Oligodendroglioma cells shed microvesicles which contain TRAIL as well as molecular chaperones and induce cell death in astrocytes.

  2011cited by this paper
• Biological effects of inorganic arsenic on primary cultures of rat astrocytes.

  2010cited by this paper
• Valproic acid as a promising agent to combat Alzheimer's disease.

  2010cited by this paper
• Formation of optically pure N-acyl-N,N'-dicyclohexylurea in N,N'-dicyclohexylcarbodiimide-mediated peptide synthesis.

  2009cited by this paper
• The effect of cadmium on brain cells in culture.

  2009cited by this paper
• Transport of valproate at intestinal epithelial (Caco-2) and brain endothelial (RBE4) cells: mechanism and substrate specificity.

  2008cited by this paper
• Synthesis and in vitro studies on a potential dopamine prodrug.

  2008cited by this paper
• Synthesis and anticonvulsant activity of aromatic tetramethylcyclopropanecarboxamide derivatives.

  2008cited by this paper
• Evaluation of galantamine transbuccal absorption by reconstituted human oral epithelium and porcine tissue as buccal mucosa models: part I.

  2008cited by this paper
• The highly permeable blood-brain barrier: an evaluation of current opinions about brain uptake capacity.

  2007cited by this paper
• Neurons produce FGF2 and VEGF and secrete them at least in part by shedding extracellular vesicles

  2007cited by this paper
• Valproic Acid Is Not a Substrate for P-glycoprotein or Multidrug Resistance Proteins 1 and 2 in a Number of in Vitro and in Vivo Transport Assays

  2007cited by this paper
• A simple technique for quantifying apoptosis in 96-well plates

  2005cited by this paper
• Development and application of high throughput plasma stability assay for drug discovery.

  2005cited by this paper
• Permeability properties of a three‐cell type in vitro model of blood‐brain barrier

  2005cited by this paper
• Valproate: a simple chemical with so much to offer

  2005cited by this paper
• Teratogenicity of antiepileptic drugs: state of the art: review

  2005cited by this paper
• Mechanisms of Disease: The Blood-Brain Barrier

  2004cited by this paper
• Pharmacological and electrographic properties of epileptiform activity induced by elevated K2+ and lowered Ca2+ and Mg2+ concentration in rat hippocampal slices

  2004cited by this paper
• New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet?

  2003cited by this paper
• Children Versus Adults: Pharmacokinetic and Adverse‐Effect Differences

  2002cited by this paper
• Mechanisms of action of valproate: a commentatory.

  2000cited by this paper
• Current aspects of valproate in bipolar disorder.

  2000cited by this paper
• Probenecid-inhibitable efflux transport of valproic acid in the brain parenchymal cells of rabbits: a microdialysis study.

  2000cited by this paper
• Synthesis and characterization of aminoacidic pro-drugs of valproic acid.

  1998cited by this paper
• Studies on the teratogen pharmacophore of valproic acid analogues: evidence of interactions at a hydrophobic centre.

  1998cited by this paper
• Comparison of Effects of Valproate and Trans‐2‐en‐Valproate on Different Forms of Epileptiform Activity in Rat Hippocampal and Temporal Cortex Slices

  1998cited by this paper
• Further branching of valproate-related carboxylic acids reduces the teratogenic activity, but not the anticonvulsant effect.

  1996cited by this paper

• Mitochondrial protection and anti-inflammatory effect of curcumin in inhibiting reproductive toxicity induced by sodium valproate in male mice

  2025cites this paper
• Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results

  2022cites this paper
• Design, synthesis and anticancer activity of novel valproic acid conjugates with improved histone deacetylase (HDAC) inhibitory activity.

  2020cites this paper
• Phenylalanine derivatives with modulating effects on human α1-glycine receptors and anticonvulsant activity in strychnine-induced seizure model in male adult rats.

  2017cites this paper
• Small endogenous molecules as moiety to improve targeting of CNS drugs

  2017cites this paper
• Assessment of in vivo organ-uptake and in silico prediction of CYP mediated metabolism of DA-Phen, a new dopaminergic agent

  2017cites this paper
• Design, synthesis and preliminary evaluation of dopamine-amino acid conjugates as potential D1 dopaminergic modulators.

  2016cites this paper
• Valproic acid enhances neuronal differentiation of sympathoadrenal progenitor cells

  2015cites this paper