Picrotoxin Accelerates Relaxation of GABAC Receptors

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Molecular Pharmacology

• Publication date

  2005-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1124/MOL.104.003996PMID 15509715
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Studies on the mechanisms of action of picrotoxin, quercetin and pregnanolone at the GABAρ1 receptor

  2004cited by this paper
• International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

  2003cited by this paper
• Co-assembly of GABA rho subunits with the GABA(A) receptor gamma(2) subunit cloned from white perch retina.

  2002cited by this paper
• Identification of a Novel Residue within the Second Transmembrane Domain That Confers Use-facilitated Block by Picrotoxin in Glycine α1 Receptors*

  2002cited by this paper
• Drug interactions at GABA(A) receptors.

  2002cited by this paper
• Co-assembly of GABA ρ subunits with the GABAA receptor γ2 subunit cloned from white perch retina

  2002cited by this paper
• The GABAC receptors of retinal neurons.

  2001influential reference
• Neuromuscular transmission on the rebound.

  2001cited by this paper
• Constructing inhibitory synapses

  2001cited by this paper
• Chloride channels of glycine and GABA receptors with blockers: Monte Carlo minimization and structure-activity relationships.

  2000cited by this paper
• Subunit-specific action of an anticonvulsant thiobutyrolactone on recombinant glycine receptors involves a residue in the M2 membrane-spanning region.

  2000cited by this paper
• Response kinetics and pharmacological properties of heteromeric receptors formed by coassembly of GABA rho- and gamma2-subunits

  1999cited by this paper
• Dopamine activates two different receptors to produce variability in sign at an identified synapse.

  1999cited by this paper
• Channel opening locks agonist onto the GABAC receptor

  1999influential reference
• International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.

  1998influential reference
• Molecular and pharmacological properties of GABA-rho subunits from white perch retina.

  1998influential reference
• From GABAA receptor diversity emerges a unified vision of GABAergic inhibition.

  1998cited by this paper
• A comparison of GABAC and ρ subunit receptors from the white perch retina

  1997influential reference
• Insights into the activation mechanism of rho1 GABA receptors obtained by coexpression of wild type and activation-impaired subunits.

  1996cited by this paper
• Use-dependent and use-independent blocking actions of picrotoxin and zinc at the GABAC receptor in retinal horizontal cells.

  1996cited by this paper
• Design and in vitro pharmacology of a selective gamma-aminobutyric acidC receptor antagonist.

  1996cited by this paper
• Insights into the activation mechanism of ρ1 GABA receptors obtained by coexpression of wild type and activation-impaired subunits

  1996cited by this paper
• Inhibitory glutamate receptor channels

  1996cited by this paper
• Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block.

  1995cited by this paper
• A single amino acid in gamma-aminobutyric acid rho 1 receptors affects competitive and noncompetitive components of picrotoxin inhibition.

  1995influential reference
• Point mutations in the M2 region of the alpha, beta, or gamma subunit of the GABAA channel that abolish block by picrotoxin.

  1995cited by this paper
• Mutations Affecting the Glycine Receptor Agonist Transduction Mechanism Convert the Competitive Antagonist, Picrotoxin, into an Allosteric Potentiator (*)

  1995influential reference
• GABAA and GABAC receptors on hybrid bass retinal bipolar cells.

  1995cited by this paper
• Zinc is a mixed antagonist of homomeric rho 1 gamma-aminobutyric acid-activated channels.

  1995cited by this paper
• GABAA/benzodiazepine receptor heterogeneity: neurophysiological implications.

  1995cited by this paper
• A single histidine residue is essential for zinc inhibition of GABA rho 1 receptors

  1995cited by this paper
• A single aminoacidiny-aminobutyric acidplreceptors affects competitive andnoncompetitive components of picrotoxin inhibition

  1995influential reference
• GABAA receptor channels.

  1994cited by this paper
• Pharmacology of novel GABA receptors found on rod horizontal cells of the white perch retina

  1994cited by this paper
• Synthetic peptides and four-helix bundle proteins as model systems for the pore-forming structure of channel proteins. II. Transmembrane segment M2 of the brain glycine receptor is a plausible candidate for the pore-lining structure.

  1993cited by this paper
• On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat.

  1992cited by this paper
• Characterization of bicuculline/baclofen-insensitive gamma-aminobutyric acid receptors expressed in Xenopus oocytes. I. Effects of Cl- channel inhibitors.

  1992cited by this paper
• The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels.

  1992cited by this paper
• ATP-activated channels in rat and bullfrog sensory neurons: concentration dependence and kinetics

  1990cited by this paper
• Blockade of γ-aminobutyric acid-gated chloride current in frog sensory neurons by picrotoxin

  1988cited by this paper
• Blockade of gamma-aminobutyric acid-gated chloride current in frog sensory neurons by picrotoxin.

  1988cited by this paper
• Electrophysiology of GABAA and GABAB receptor subtypes.

  1988cited by this paper
• Studies on the mechanism of action of picrotoxinin and other convulsants at the crustacean muscle GABA receptor

  1986cited by this paper
• On the stochastic properties of single ion channels

  1981cited by this paper
• Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

  1981cited by this paper
• A comparison of similar ionic responses to gamma-aminobutyric acid and acetylcholine.

  1978cited by this paper

• Using optogenetics to dissect rod inputs to OFF ganglion cells in the mouse retina

  2023cites this paper
• Handbook of Ion Channels

  2023cites this paper
• Structure and dynamics of differential ligand binding in the human ρ-type GABAA receptor

  2023cites this paper
• Picrotoxane sesquiterpenoids: chemistry, chemo- and bio-syntheses and biological activities.

  2022cites this paper
• Nodulisporic acid produces direct activation and positive allosteric modulation of AVR-14B, a glutamate-gated chloride channel from adult Brugia malayi

  2022cites this paper
• GABAA receptor signalling mechanisms revealed by structural pharmacology

  2019cites this paper
• CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with picrotoxin and megabody Mb38.

  2019cites this paper
• Branched-Chain Amino Acids and Seizures: A Systematic Review of the Literature

  2019cites this paper
• The dual‐gate model for pentameric ligand‐gated ion channels activation and desensitization

  2018cites this paper
• Dipicrylamine Modulates GABAρ1 Receptors through Interactions with Residues in the TM4 and Cys-Loop Domains

  2016cites this paper
• Molecular cloning and expression of a GABA receptor subunit from the crayfish Procambarus clarkii

  2016cites this paper
• Kinetics of Inhibitory Feedback from Horizontal Cells to Photoreceptors: Implications for an Ephaptic Mechanism

  2016cites this paper
• Amiloride and GMQ Allosteric Modulation of the GABA-A ρ1 Receptor: Influences of the Intersubunit Site

  2015cites this paper
• Characterization of the interactions of guanidine compounds with the human GABA-A rho1 receptor

  2015influential citation
• GMQ allosteric modulation of the GABAA ρ 1 receptor : influences of the intersubunit site

  2015influential citation
• Identification of a possible secondary picrotoxin-binding site on the GABA(A) receptor.

  2013cites this paper
• Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors

  2012cites this paper
• Dopamine and serotonin modulate human GABAρ1 receptors expressed in Xenopus laevis oocytes.

  2012cites this paper
• Modulation of GABA(A) receptors by natural products and the development of novel synthetic ligands for the benzodiazepine binding site.

  2011cites this paper
• The GABA Antagonist Picrotoxin Attenuates an Ethanol-Induced Taste Aversion in Taste Aversion-Prone Rats

  2011cites this paper
• Neurovascular Interaction and the Pathophysiology of Diabetic Retinopathy

  2011cites this paper
• Molecular pharmacology of an insect GABA receptor

  2010cites this paper
• Effects of Antiepileptic Agents on Homotypic Fusion of Synaptic Vesicles

  2009cites this paper
• Relative impact of residues at the intracellular and extracellular ends of the human GABAC rho1 receptor M2 domain on picrotoxinin activity.

  2008cites this paper
• Cyclothiazide: a subunit‐specific inhibitor of GABAC receptors

  2008cites this paper
• Anticonvulsant effect of a natural compound alpha,beta-epoxy-carvone and its action on the nerve excitability.

  2008cites this paper
• Anticonvulsant effect of a natural compound ,-epoxy-carvone and its action on the nerve excitability

  2008cites this paper
• Stability of picrotoxin during yogurt manufacture and storage.

  2008cites this paper
• Neuroactive Steroids and Human Recombinant ρ1 GABA Receptors

  2007cites this paper
• Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides.

  2007cites this paper
• EXPRESSION OF FUNCTIONAL GABA C RECEPTORS IN THE BRAIN

  2007cites this paper
• Streptozotocin-induced diabetes modulates GABA receptor activity of rat retinal neurons.

  2007cites this paper
• Expression of functional GABAc receptors in the brain

  2007cites this paper
• Mechanisms for Picrotoxinin and Picrotin Blocks of α2 Homomeric Glycine Receptors*

  2007cites this paper
• Os Efeitos de Organocalcogêneos e de 2,3-Dimercaptopropanol Sobre Convulsão Química e Letalidade Induzidas por Pentilenotetrazol e 4-Aminopiridina em Camundongos

  2007cites this paper
• Activation of membrane receptors by neurotransmitter released from temperature-sensitive hydrogels.

  2006cites this paper
• Mechanisms for picrotoxin block of alpha2 homomeric glycine receptors.

  2006cites this paper
• Modulation of ionotropic GABA receptors by natural products of plant origin.

  2006cites this paper
• High pH accelerates GABA deactivation on perch-ρ1B receptors

  2006cites this paper
• Mixed antagonistic effects of bilobalide at ρ1 GABAC receptor

  2006cites this paper
• Intra-cortical Inhibition in the Regulation of Receptive Field Properties And Neural Plasticity in the Primary Visual Cortex

  2006cites this paper
• Plasticity in the Visual System

  2006cites this paper
• High pH accelerates GABA deactivation on perch-rho1B receptors.

  2006cites this paper
• Mixed antagonistic effects of bilobalide at rho1 GABAC receptor.

  2006cites this paper
• Structural features of phenol derivatives determining potency for activation of chloride currents via alpha(1) homomeric and alpha(1)beta heteromeric glycine receptors.

  2005cites this paper
• A Picrotoxin-specific Conformational Change in the Glycine Receptor M2–M3 Loop*

  2005cites this paper
• Structural features of phenol derivatives determining potency for activation of chloride currents via α1 homomeric and α1β heteromeric glycine receptors

  2005cites this paper
• IXED ANTAGONISTIC EFFECTS OF BILOBALIDE AT 1 GABAC ECEPTOR

  2005cites this paper