Molecular Genetics of Familial Adenomatous Polyposis

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/978-1-4419-6603-2_3
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia

  2007cited by this paper
• The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression.

  2007cited by this paper
• Myc deletion rescues Apc deficiency in the small intestine

  2007cited by this paper
• Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner.

  2007cited by this paper
• Identification of Mom7, a Novel Modifier of ApcMin/+ on Mouse Chromosome 18

  2007cited by this paper
• Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability.

  2007cited by this paper
• APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice

  2007cited by this paper
• Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC

  2006cited by this paper
• Wnt signaling and gastrointestinal tumorigenesis in mouse models

  2006cited by this paper
• The Third 20 Amino Acid Repeat Is the Tightest Binding Site of APC for β-Catenin

  2006cited by this paper
• Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo

  2006cited by this paper
• Smad4 haploinsufficiency in mouse models for intestinal cancer

  2006cited by this paper
• Epigenetics, mismatch repair genes and colorectal cancer.

  2005cited by this paper
• Cyclin D1 Is Not an Immediate Target of β-Catenin following Apc Loss in the Intestine*

  2005cited by this paper
• Molecular analysis of APC promoter methylation and protein expression in colorectal cancer metastasis.

  2005cited by this paper
• The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis.

  2005cited by this paper
• Redefining the subcellular location and transport of APC: new insights using a panel of antibodies

  2005cited by this paper
• EphB receptor activity suppresses colorectal cancer progression

  2005cited by this paper
• Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice.

  2005cited by this paper
• EphB receptor activity suppresses colorectal cancer progression (vol 435, pg 1126, 2005)

  2005cited by this paper
• Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine

  2005cited by this paper
• Cyclin D1 Genetic Heterozygosity Regulates Colonic Epithelial Cell Differentiation and Tumor Number in ApcMin Mice

  2004cited by this paper
• Promoter hypermethylation of tumor‐related genes in the progression of colorectal neoplasia

  2004cited by this paper
• Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases

  2004cited by this paper
• Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers

  2004cited by this paper
• APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q1

  2004cited by this paper
• APC mutations in sporadic colorectal carcinomas from The Netherlands Cohort Study.

  2004cited by this paper
• Multiple approach to the exploration of genotype-phenotype correlations in familial adenomatous polyposis.

  2003cited by this paper
• Pathology of mouse models of intestinal cancer: consensus report and recommendations.

  2003cited by this paper
• Spontaneous aberrant crypt foci in Apc1638N mice with a mutant Apc allele.

  2003cited by this paper
• Refining the relation between ‘first hits’ and ‘second hits’ at the APC locus: the ‘loose fit’ model and evidence for differences in somatic mutation spectra among patients

  2003cited by this paper
• Mutated APC and Asef are involved in the migration of colorectal tumour cells

  2003cited by this paper
• Explaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes

  2002cited by this paper
• Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia.

  2002cited by this paper
• Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis.

  2002cited by this paper
• The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

  2002cited by this paper
• Compound disruption of smad2 accelerates malignant progression of intestinal tumors in apc knockout mice.

  2002cited by this paper
• Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors

  2002cited by this paper
• The ABC of APC.

  2001cited by this paper
• Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.

  2000cited by this paper
• Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522.

  2000cited by this paper
• The Mom1AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64

  2000cited by this paper
• Tumor-associated Apc mutations in Mlh1−/−Apc1638N mice reveal a mutational signature of Mlh1 deficiency

  2000cited by this paper
• Cancer predisposition caused by elevated mitotic recombination in Bloom mice

  2000cited by this paper
• APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits".

  2000cited by this paper
• The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression.

  2000cited by this paper
• Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers.

  2000cited by this paper
• The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

  1999cited by this paper
• β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

  1999cited by this paper
• APC: the plot thickens.

  1999cited by this paper
• Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice.

  1999cited by this paper
• Notes from some crypt watchers: regulation of renewal in the mouse intestinal epithelium.

  1998cited by this paper
• Piroxicam and Acarbose as Chemopreventive Agents for Spontaneous Intestinal Adenomas in APC Gene 1309 Knockout Mice

  1998cited by this paper
• Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice.

  1998cited by this paper
• Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts.

  1998cited by this paper
• The APC I1307K allele and cancer risk in a community-based study of Ashkenazi Jews

  1998cited by this paper
• Somatic instability of the APC I1307K allele in colorectal neoplasia.

  1998cited by this paper
• Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes.

  1998cited by this paper
• Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.

  1998cited by this paper
• Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration.

  1997cited by this paper
• Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene.

  1997cited by this paper
• Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis.

  1997cited by this paper
• Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC

  1997cited by this paper
• Morphological and molecular processes of polyp formation in Apc(delta716) knockout mice.

  1997cited by this paper
• Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

  1997cited by this paper
• Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice.

  1996cited by this paper
• Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice.

  1996cited by this paper
• APC gene: database of germline and somatic mutations in human tumors and cell lines

  1996cited by this paper
• Meiotic pachytene arrest in MLH1-deficient mice.

  1996cited by this paper
• Variants at the secretory phospholipase A2 (PLA2G2A) locus: analysis of associations with familial adenomatous polyposis and sporadic colorectal tumours

  1996cited by this paper
• Lessons from Hereditary Review Colorectal Cancer

  1996cited by this paper
• MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis.

  1996cited by this paper
• Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis.

  1995cited by this paper
• Attenuated familial adenomatous polyposis (AFAP) a phenotypically and genotypically distinctive variant of FAP

  1995cited by this paper
• The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia.

  1995cited by this paper
• Alternatively spliced adenomatous polyposis coli (APC) gene transcripts that delete exons mutated in attenuated APC.

  1995cited by this paper
• Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.

  1995cited by this paper
• MSH2 deficient mice are viable and susceptible to lymphoid tumours

  1995cited by this paper
• The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.

  1994cited by this paper
• Phenotypic expression in familial adenomatous polyposis: partial prediction by mutation analysis.

  1994cited by this paper
• A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.

  1994cited by this paper
• Wild-type but not mutant APC associates with the microtubule cytoskeleton.

  1994cited by this paper
• Multiple forms of the APC gene transcripts and their tissue-specific expression.

  1993cited by this paper
• Dimer formation by an N-terminal coiled coil in the APC protein.

  1993cited by this paper
• Identification of an alternative 5′ untranslated region of the adenomatous polyposis coli gene

  1993cited by this paper
• Mutations of the APC adenomatous polyposis coli) gene

  1993cited by this paper
• Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse.

  1993cited by this paper
• The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system

  1992cited by this paper
• Erratum: Multiple Intestinal Neoplasia Caused By a Mutation in the Murine Homolog of the APC Gene

  1992cited by this paper
• A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.

  1990cited by this paper
• The gene for familial polyposis coli maps to the long arm of chromosome 5.

  1987cited by this paper
• Localization of the gene for familial adenomatous polyposis on chromosome 5

  1987cited by this paper
• Chromosome 5 allele loss in human colorectal carcinomas

  1987cited by this paper
• A genetic linkage map of the human genome.

  1987cited by this paper
• Gardner syndrome in a man with an interstitial deletion of 5q.

  1986cited by this paper
• Hypervariable ‘minisatellite’ regions in human DNA

  1985cited by this paper
• Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types.

  1974cited by this paper

• Hereditary predispositions to tumors, tumor suppressor genes, and their clinico-genomic complexities

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• Clinical manifestations of colorectal cancer patients from a large multicenter study in Colombia

  2016cites this paper
• Etio-Pathogenesis IV: Heredity

  2015cites this paper
• Etio-Pathogenesis III

  2015cites this paper
• Hereditary Colorectal Cancer

  2010cites this paper
• Genotype Phenotype Correlation in Familial Adenomatous Polyposis

  2010cites this paper