Spindle assembly requires complete disassembly of spindle remnants from the previous cell cycle

Jeffrey B. Woodruff,D. Drubin,G. Barnes

Published 2012 in Molecular Biology of the Cell

ABSTRACT

Incomplete spindle disassembly causes lethality in budding yeast. We propose that spindle disassembly is required to reinitiate the spindle cycle during the subsequent mitosis by regenerating the nuclear pool of assembly-competent tubulin.

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