Potent μ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Medicinal Chemistry

• Publication date

  2016-01-29

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/acs.jmedchem.5b01899PMID 26789491
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Synthesis of mixed opioid affinity cyclic endomorphin-2 analogues with fluorinated phenylalanines.

  2015cited by this paper
• Fluorescent mu selective opioid ligands from a mixture based cyclic peptide library.

  2012cited by this paper
• Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selective μ opioid receptor Agents.

  2012cited by this paper
• Lipo-Endomorphin-1 Derivatives with Systemic Activity against Neuropathic Pain without Producing Constipation

  2012cited by this paper
• The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues.

  2012cited by this paper
• Design, synthesis and pharmacological characterization of endomorphin analogues with non-cyclic amino acid residues in position 2.

  2010cited by this paper
• Synthesis of cyclic peptides through direct aminolysis of peptide thioesters catalyzed by imidazole in aqueous organic solutions.

  2009cited by this paper
• NMR spectroscopy and molecular modelling studies of nitrosylcobalamin: further evidence that the deprotonated, base-off form is important for nitrosylcobalamin in solution.

  2009cited by this paper
• Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors.

  2009cited by this paper
• Antimicrobial peptides with stability toward tryptic degradation.

  2008cited by this paper
• High throughput synthesis of peptide alpha-thioesters through the use of "volatilizable" support.

  2008cited by this paper
• Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues.

  2004cited by this paper
• Synthesis and evaluation of the affinity toward mu-opioid receptors of atypical, lipophilic ligands based on the sequence c[-Tyr-Pro-Trp-Phe-Gly-].

  2004cited by this paper
• New trends in the development of opioid peptide analogues as advanced remedies for pain relief.

  2004cited by this paper
• Membrane potential fluorescence: A rapid and highly sensitive assay for nicotinic receptor channel function

  2003cited by this paper
• Two distinct forms of desensitization of G-protein coupled inwardly rectifying potassium currents evoked by alkaloid and peptide mu-opioid receptor agonists.

  2003cited by this paper
• Dissociation of analgesic and rewarding effects of endomorphin-1 in rats.

  2000cited by this paper
• Preferred conformation of endomorphin-1 in aqueous and membrane-mimetic environments.

  1999cited by this paper
• Conformational analysis of the endogenous μ‐opioid agonist endomorphin‐1 using NMR spectroscopy and molecular modeling

  1998cited by this paper
• A potent and selective endogenous agonist for the mu-opiate receptor.

  1997cited by this paper
• Temperature dependence of 1H chemical shifts in proteins

  1997cited by this paper
• A potent and selective endogenous agonist for the µ-opiate receptor

  1997cited by this paper

• Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics

  2022cites this paper
• Biased Agonism: Lessons from Studies of Opioid Receptor Agonists.

  2022cites this paper
• Cyclizing Painkillers: Development of Backbone-Cyclic TAPS Analogs

  2020cites this paper
• A novel G protein‐biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein‐coupled receptor kinase

  2020cites this paper
• Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs.

  2019cites this paper
• Endogenous Opiates and Behavior: 2016.

  2018cites this paper
• Cyclic Opioid Peptides.

  2016cites this paper
• Synthesis, Spatial Structure and Analgesic Activity of Sodium 3-Benzylaminocarbonyl-1-methyl-2,2-dioxo-1H-2λ6,1-benzothiazin-4-olate Solvates

  2016cites this paper