Skeletal muscle heat shock protein 70: diverse functions and therapeutic potential for wasting disorders

The stress-inducible 70-kDa heat shock protein (HSP70) is a highly conserved protein with diverse intracellular and extracellular functions. In skeletal muscle, HSP70 is rapidly induced in response to both non-damaging and damaging stress stimuli including exercise and acute muscle injuries. This upregulation of HSP70 contributes to the maintenance of muscle fiber integrity and facilitates muscle regeneration and recovery. Conversely, HSP70 expression is decreased during muscle inactivity and aging, and evidence supports the loss of HSP70 as a key mechanism which may drive muscle atrophy, contractile dysfunction and reduced regenerative capacity associated with these conditions. To date, the therapeutic benefit of HSP70 upregulation in skeletal muscle has been established in rodent models of muscle injury, muscle atrophy, modified muscle use, aging, and muscular dystrophy, which highlights HSP70 as a key therapeutic target for the treatment of various conditions which negatively affect skeletal muscle mass and function. This article will review these important findings and provide perspective on the unanswered questions related to HSP70 and skeletal muscle plasticity which require further investigation.

• Publication year

  2013

• Venue

  Frontiers in Physiology

• Publication date

  2013-10-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3389/fphys.2013.00330PMID 24273516PMCID 3822288
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• HSP70 upregulation is supported as a therapeutic target across rodent models of skeletal muscle wasting disorders.

  Confidence 0.93

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) review
• HSP70 expression decreases during muscle inactivity and aging.

  Confidence 0.95

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) review
• HSP70 contributes to muscle fiber integrity and recovery in skeletal muscle.

  Confidence 0.92

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) review
• HSP70 is rapidly induced in skeletal muscle in response to acute muscle injury.

  Confidence 0.96

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) review

• aging

  condition

  The age-related state of skeletal muscle discussed as another context for lower HSP70 expression.

  Aliases: ageing

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) review
• hsp70

  protein

  A stress-inducible 70-kDa heat shock protein that is the central molecule discussed in the abstract.

  Aliases: heat shock protein 70, HSP 70

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) review
• hsp70 upregulation

  process

  An increase in HSP70 expression or abundance in skeletal muscle.

  Aliases: HSP70 induction, upregulation of HSP70

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) review
• muscle inactivity

  condition, physiological state

  A low-use state of skeletal muscle associated with reduced HSP70 expression.

  Aliases: inactivity

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) review
• muscle injury

  injury, condition

  Acute damage to skeletal muscle used as a damaging stress stimulus.

  Aliases: acute muscle injury, acute muscle injuries

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) review
• rodent models

  model system

  Mouse and rat experimental systems used to test skeletal muscle injury, disuse, and disease states.

  Aliases: preclinical rodent models

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) review
• skeletal muscle

  tissue

  Striated muscle tissue studied here for its stress responses, maintenance, and regeneration.

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) review
• skeletal muscle wasting disorders

  condition, disease

  Conditions that reduce skeletal muscle mass and function.

  Aliases: wasting disorders

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) review

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