Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Molecules and Cells

• Publication date

  2015-06-18

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.molcel.2015.05.010PMID 26051179PMCID PMC4476372
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.

  2014cited by this paper
• Autophagy in human health and disease.

  2013cited by this paper
• Autophagy Promotes Primary Ciliogenesis by Removing OFD1 from Centriolar Satellites

  2013cited by this paper
• Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression.

  2013cited by this paper
• Functional interaction between autophagy and ciliogenesis

  2013cited by this paper
• Autophagy in human health and disease.

  2013cited by this paper
• A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

  2013influential reference
• mTOR signaling in growth control and disease.

  2012cited by this paper
• The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis.

  2012influential reference
• Guidelines for the use and interpretation of assays for monitoring autophagy

  2012cited by this paper
• Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.

  2012cited by this paper
• Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

  2012influential reference
• Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation

  2012cited by this paper
• Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

  2011cited by this paper
• Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice.

  2010cited by this paper
• Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

  2010influential reference
• Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

  2010cited by this paper
• GTPase Activity Plays a Key Role in the Pathobiology of LRRK2

  2010cited by this paper
• mTOR: from growth signal integration to cancer, diabetes and ageing

  2010cited by this paper
• The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

  2009cited by this paper
• Centrioles, centrosomes, and cilia in health and disease.

  2009cited by this paper
• Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

  2009cited by this paper
• Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

  2008cited by this paper
• Regulation of TORC1 by Rag GTPases in nutrient response

  2008influential reference
• The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

  2008influential reference
• The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway

  2008cited by this paper
• Defining the role of mTOR in cancer.

  2007cited by this paper
• Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity.

  2007cited by this paper
• Regulation of the small GTPase Rheb by amino acids

  2006cited by this paper
• Nutrients Suppress Phosphatidylinositol 3-Kinase/Akt Signaling via Raptor-Dependent mTOR-Mediated Insulin Receptor Substrate 1 Phosphorylation

  2006cited by this paper
• Growing roles for the mTOR pathway.

  2005cited by this paper
• The Tuberous Sclerosis Protein TSC2 Is Not Required for the Regulation of the Mammalian Target of Rapamycin by Amino Acids and Certain Cellular Stresses*

  2005cited by this paper
• Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

  2005cited by this paper
• Skp2-mediated degradation of p27 regulates progression into mitosis.

  2004cited by this paper
• Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

  2004cited by this paper
• Skp2-dependent degradation of p27kip1 is essential for cell cycle progression.

  2004cited by this paper
• Novel G Proteins, Rag C and Rag D, Interact with GTP-binding Proteins, Rag A and Rag B*

  2001cited by this paper
• Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication

  2000cited by this paper
• RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway.

  1998cited by this paper

• Targeting ubiquitination in disease and therapy

  2025cites this paper
• Potential biomarkers in early detection of gastric cancer

  2025cites this paper
• Targeting mTOR Kinase for Cancer Treatment: A Comprehensive Review With Clinical Insights

  2025cites this paper
• Inhibition of Skp2 enhances anti-tumor immunity of macrophages by regulating CD47 in gastric cancer.

  2025cites this paper
• Systemic identification of functionally conserved lncRNA metabolic regulators in human and mouse livers.

  2025cites this paper
• mTor limits autophagy to facilitate cell volume expansion and rapid wound repair in Drosophila embryos.

  2025cites this paper
• Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation

  2025cites this paper
• FBXO2-mediated KPTN ubiquitination promotes amino acid–dependent mTORC1 signaling and tumor growth

  2025cites this paper
• The Role of the PI3K/Akt/mTOR Pathway in Atherosclerosis: Mechanisms, Therapeutic Potential, and Emerging Targeted Treatments

  2025cites this paper
• CUL1 variants cause severe neurodevelopmental disorders: Insights from human genetics and a zebrafish model of microcephaly

  2025cites this paper
• TRAF4‐Mediated LAMTOR1 Ubiquitination Promotes mTORC1 Activation and Inhibits the Inflammation‐Induced Colorectal Cancer Progression

  2024cites this paper
• Nutrient Sensing of mTORC1 signaling in cancer and aging.

  2024cites this paper
• mTOR in metabolic homeostasis and disease.

  2024cites this paper
• SUMO modifies GβL and mediates mTOR signaling

  2024cites this paper
• Post-translational regulation of the mTORC1 pathway: A switch that regulates metabolism-related gene expression.

  2024cites this paper
• HSP70 promotes amino acid‐dependent mTORC1 signaling by mediating CHIP‐induced NPRL2 ubiquitination and degradation

  2024cites this paper
• Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells

  2023cites this paper
• α-hederin regulates glucose metabolism in intestinal epithelial cells by increasing SNX10 expression.

  2023cites this paper
• mTOR inhibits autophagy to facilitate cell swelling and rapid wound repair

  2023cites this paper
• Novel insights into mTOR signalling pathways: A paradigm for targeted tumor therapy

  2023cites this paper
• RAGA prevents tumor immune evasion of LUAD by promoting CD47 lysosome degradation

  2023cites this paper
• NUMB facilitates autophagy initiation through targeting SCFβ-TrCP2 complex

  2022cites this paper
• A negative feedback loop of TOR signaling balances growth and stress-response trade-offs in plants.

  2022cites this paper
• Therapeutic role of mTOR inhibitors in control of SARS-CoV-2 viral replication

  2022cites this paper
• The central role of mTORC1 in amino acid sensing.

  2022cites this paper
• Protein post-translational modifications in the regulation of cancer hallmarks

  2022cites this paper
• The role of lysosomes in autophagy

  2022cites this paper
• The Roles of Post-Translational Modifications on mTOR Signaling

  2021cites this paper
• SEA and GATOR 10 Years Later

  2021cites this paper
• Regulation of mTORC1 by amino acids in mammalian cells: A general picture of recent advances

  2021cites this paper
• Botanical Drug Puerarin Ameliorates Liposaccharide-Induced Depressive Behaviors in Mice via Inhibiting RagA/mTOR/p70S6K Pathways

  2021cites this paper
• Combination of artesunate and WNT974 induces KRAS protein degradation by upregulating E3 ligase ANACP2 and β-TrCP in the ubiquitin–proteasome pathway

  2021cites this paper
• A Destiny for Degradation: Interplay between Cullin-RING E3 Ligases and Autophagy.

  2021cites this paper
• Recent insight into the role of FBXW7 as a tumor suppressor.

  2020cites this paper
• The Skp2 Pathway: A Critical Target for Cancer Therapy.

  2020cites this paper
• The role of ubiquitination in tumorigenesis and targeted drug discovery

  2020cites this paper
• Clinicopathological features of pseudomyogenic hemangioendothelioma and precision therapy based on whole exome sequencing

  2020cites this paper
• F-Box Proteins and Cancer

  2020cites this paper
• Crosstalk dynamics between the circadian clock and the mTORC1 pathway.

  2020cites this paper
• Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes

  2020cites this paper
• SUMO Modifies GβL and Mediates mTOR Signaling

  2020cites this paper
• A negative feedback loop of the TOR signaling moderates growth and enables rapid sensing of stress signals in plants

  2020cites this paper
• Human Cytomegalovirus Inhibits Autophagy of Renal Tubular Epithelial Cells and Promotes Cellular Enlargement

  2020cites this paper
• The role of ubiquitination and deubiquitination in cancer metabolism

  2020cites this paper
• Cross Talk Networks of Mammalian Target of Rapamycin Signaling With the Ubiquitin Proteasome System and Their Clinical Implications in Multiple Myeloma.

  2019cites this paper
• The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity

  2019cites this paper
• mTOR as a central hub of nutrient signalling and cell growth

  2019cites this paper
• Targeting mTOR for cancer therapy

  2019cites this paper
• Preeclampsia is Associated with Sex-Specific Transcriptional and Proteomic Changes in Fetal Erythroid Cells

  2019cites this paper
• Sensors for the mTORC1 pathway regulated by amino acids

  2019cites this paper
• RagC phosphorylation autoregulates mTOR complex 1

  2018cites this paper
• Ubiquitination of Rheb governs growth factor-induced mTORC1 activation

  2018cites this paper
• Amino acid starvation promotes podocyte autophagy through mammalian target of rapamycin inhibition and transcription factor EB activation

  2018cites this paper
• mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome

  2018cites this paper
• Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex

  2018cites this paper
• OTUB1 protein suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR

  2018cites this paper
• Glucose deprivation induces primary cilium formation through mTORC1 inactivation

  2018influential citation
• Control of mTOR Signaling by Ubiquitin

  2018cites this paper
• The Architecture of the Rag GTPase Signaling Network

  2017cites this paper
• Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer

  2017cites this paper
• mTORC1 as the main gateway to autophagy

  2017cites this paper
• TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling

  2017cites this paper
• MicroRNA-365 accelerates cardiac hypertrophy by inhibiting autophagy via the modulation of Skp2 expression.

  2017cites this paper
• Nutrient sensing and TOR signaling in yeast and mammals

  2017cites this paper
• MYC Modulation around the CDK2/p27/SKP2 Axis

  2017cites this paper
• Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals.

  2017cites this paper
• The Cilium: Cellular Antenna and Central Processing Unit

  2017cites this paper
• The lysosome as a command-and-control center for cellular metabolism

  2016cites this paper
• Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling

  2016cites this paper
• Rag GTPase in amino acid signaling

  2016cites this paper
• Primary-cilium-dependent autophagy controls epithelial cell volume in response to fluid flow

  2016cites this paper
• Autophagy and primary cilia: dual interplay.

  2016cites this paper
• Cullin-RING ligases in regulation of autophagy

  2016cites this paper
• Unsolved mysteries of Rag GTPase signaling in yeast

  2016cites this paper
• TOR Complexes and the Maintenance of Cellular Homeostasis.

  2016cites this paper
• The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.

  2016cites this paper
• Rags to riches: Amino acid sensing by the Rag GTPases in health and disease

  2016cites this paper
• Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism‐like phenotype in mice

  2016cites this paper
• Cullin-RING ligases in regulation

  2016cites this paper
• TOR Complexes and the Maintenance of Cellular

  2016cites this paper
• Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

  2015cites this paper
• Multiple amino acid sensing inputs to mTORC1

  2015cites this paper
• Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.

  2015influential citation