Expression of Platelet-Derived Growth Factor-A (PDGF-A), PDGF-B, and PDGF Receptor-α and -β during Human Testicular Development and Disease

No abstract is available for this paper.

• Publication year

  2002

• Venue

  The Journal of Clinical Endocrinology and Metabolism

• Publication date

  2002-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/JCEM.87.5.8476
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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• Contractility and histochemistry of the myoid cell layer of the rat seminiferous tubules during postnatal development

  2004cited by this paper
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  2001cited by this paper
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  2001influential reference
• PDGF-D, a new protease-activated growth factor

  2001cited by this paper
• Nuclear Receptor Dax-1 Represses the Transcriptional Cooperation Between GATA-4 and SF-1 in Sertoli Cells1

  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
• Platelet-derived growth factor-BB stimulates hypertrophy of peritubular smooth muscle cells from rat testis in primary cultures.

  2000influential reference
• Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis.

  2000cited by this paper
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  2000influential reference
• Expression and subcellular localization of SF‐1, SOX9, WT1, and AMH proteins during early human testicular development

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Neonatal mouse gonocyte proliferation assayed by an in vitro clonogenic method.

  1999cited by this paper
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  1999cited by this paper
• Mammalian sex determination: a molecular drama.

  1999cited by this paper
• Gene interactions in gonadal development.

  1999cited by this paper
• Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice.

  1999cited by this paper
• The Wilms' tumor 1 gene: oncogene or tumor suppressor gene?

  1998cited by this paper
• Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Müllerian inhibiting substance promoter.

  1998cited by this paper
• Induction of aromatase activity in human adipose tissue stromal cells by extracellular nucleotides--evidence for P2-purinoceptors in adipose tissue.

  1998cited by this paper
• Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms.

  1998cited by this paper
• Oligodendrocyte population dynamics and the role of PDGF in vivo.

  1998cited by this paper
• A clinical overview of WT1 gene mutations

  1997cited by this paper
• Regulation of rat testis gonocyte proliferation by platelet-derived growth factor and estradiol: identification of signaling mechanisms involved.

  1997cited by this paper
• The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites.

  1997cited by this paper
• Pericyte loss and microaneurysm formation in PDGF-B-deficient mice.

  1997cited by this paper
• de la Chapelle, A.

  1997cited by this paper
• PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis.

  1996cited by this paper
• Aberrant platelet-derived growth factor alpha-receptor transcript as a diagnostic marker for early human germ cell tumors of the adult testis.

  1996cited by this paper
• Cell-type-specific expression of the platelet-derived growth factor alpha receptor: a role for GATA-binding protein

  1996cited by this paper
• The WT1 Wilms' tumor suppressor gene: how much do we really know?

  1996cited by this paper
• Platelet-derived growth factor ligand and receptor subunit mRNA in the Sertoli and Leydig cells of the rat testis.

  1995cited by this paper
• Testicular development involves the spatiotemporal control of PDGFs and PDGF receptors gene expression and action

  1995influential reference
• Platelet-derived growth factor A-chain expression in developing and mature human kidneys and in Wilms' tumor.

  1995cited by this paper
• Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing.

  1995cited by this paper
• Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

  1994cited by this paper
• RNA editing in the Wilms' tumor susceptibility gene, WT1.

  1994cited by this paper
• Growth factor expression during rat development: a comparison of TGF-beta 3, TGF-alpha, bFGF, PDGF and PDGF-R.

  1993cited by this paper
• Analysis of WT1 in granulosa cell and other sex cord-stromal tumors.

  1993cited by this paper
• The Wilms' tumor gene product WT1 activates or suppresses transcription through separate functional domains.

  1993cited by this paper
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  1993cited by this paper
• Platelet-derived growth factor effects on purified testicular peritubular myoid cells: binding, cytosolic Ca2+ increase, mitogenic activity, and extracellular matrix production enhancement.

  1993cited by this paper
• Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues.

  1993cited by this paper
• Discrete stimulatory effects of platelet-derived growth factor (PDGF-BB) on Leydig cell steroidogenesis.

  1993cited by this paper
• Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1.

  1992cited by this paper
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  1992cited by this paper
• Rat Leydig cells bind platelet-derived growth factor through specific receptors and produce platelet-derived growth factor-like molecules.

  1992cited by this paper
• Oncogenes in human testicular cancer: DNA and RNA studies.

  1991cited by this paper
• Transforming growth factor‐β and platelet‐derived growth factor synergistically stimulate contraction by testicular peritubular cells in culture in serum‐free medium

  1991cited by this paper
• Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

  1990cited by this paper
• Platelet derived growth factor inhibits 5α-reductase and Δ5-3β-hydroxysteroid dehydrogenase activities in cultured immature Leydig cells

  1990cited by this paper
• Development and regulation of growth and differentiated function in human and subhuman primate fetal gonads.

  1990cited by this paper
• Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus.

  1990cited by this paper
• Arterial smooth muscle cells express platelet-derived growth factor (PDGF) A chain mRNA, secrete a PDGF-like mitogen, and bind exogenous PDGF in a phenotype- and growth state-dependent manner

  1988cited by this paper
• Ornithine decarboxylase activity during rat spermatogenesis in vivo and in vitro: Selective effect of hormones and growth factors

  1987cited by this paper
• cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

  1986cited by this paper
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  year unknowncited by this paper
• Printed in U.S.A. Copyright © 1999 by The Endocrine Society Expression and Regulation of Transcription Factors

  year unknowncited by this paper

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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2004cites this paper
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