Mechanisms of sleep induction by GABA(A) receptor agonists.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Clinical Psychiatry

• Publication date

  2007-05-15

• Fields of study

  Medicine, Chemistry

• Identifiers
  PMID 17539703
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The National Sleep Foundation

  2007cited by this paper
• The percipient observations of Constantin von Economo on encephalitis lethargica and sleep disruption and their lasting impact on contemporary sleep research.

  2006cited by this paper
• Age‐related Changes in the Circadian and Homeostatic Regulation of Human Sleep

  2006cited by this paper
• GABAA receptor α4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol

  2006cited by this paper
• Gaboxadol--a new awakening in sleep.

  2006influential reference
• THIP, a hypnotic and antinociceptive drug, enhances an extrasynaptic GABAA receptor-mediated conductance in mouse neocortex.

  2006cited by this paper
• Gaboxadol improves sleep onset and maintenance and enhances low frequency components of NREM sleep EEG in a model of transient insomnia

  2006cited by this paper
• GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic.

  2006cited by this paper
• The hypothalamic integrator for circadian rhythms.

  2005cited by this paper
• Distinct (cid:1) 2 Subunit Domains Mediate Clustering and Synaptic Function of Postsynaptic GABA A Receptors and Gephyrin

  2005cited by this paper
• Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors

  2005cited by this paper
• Correlates and consequences of chronic insomnia.

  2005cited by this paper
• Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle

  2005cited by this paper
• An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons.

  2005cited by this paper
• Hypothalamic regulation of sleep and circadian rhythms

  2005influential reference
• Distribution of alpha1, alpha4, gamma2, and delta subunits of GABAA receptors in hippocampal granule cells.

  2004cited by this paper
• Tonically active GABA A receptors: modulating gain and maintaining the tone.

  2004cited by this paper
• Distribution of α1, α4, γ2, and δ subunits of GABAA receptors in hippocampal granule cells

  2004cited by this paper
• Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics.

  2004influential reference
• Sleep and quantitative EEG in neurodegenerative disorders.

  2004cited by this paper
• The Pharmacology and Mechanisms of Action of New Generation, Non-Benzodiazepine Hypnotic Agents

  2004cited by this paper
• Effects of lesions of the histaminergic tuberomammillary nucleus on spontaneous sleep in rats.

  2004cited by this paper
• GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic.

  2004cited by this paper
• GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?

  2003cited by this paper
• The role of histamine and the tuberomamillary nucleus in the nervous system

  2003cited by this paper
• Changes in the sleep-wake cycle architecture and cortical nitric oxide release during ageing in the rat.

  2003cited by this paper
• Waking selective neurons in the posterior hypothalamus and their response to histamine H3-receptor ligands: an electrophysiological study in freely moving cats.

  2003cited by this paper
• Afferents to the Ventrolateral Preoptic Nucleus

  2002cited by this paper
• Pharmacological characterization of a novel cell line expressing human α4β3δ GABAA receptors

  2002cited by this paper
• Ventrolateral preoptic nucleus contains sleep-active, galaninergic neurons in multiple mammalian species.

  2002cited by this paper
• Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors.

  2002cited by this paper
• The sleep switch: hypothalamic control of sleep and wakefulness.

  2001influential reference
• Effect of the GABAA agonist gaboxadol on nocturnal sleep and hormone secretion in healthy elderly subjects.

  2001cited by this paper
• GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain.

  2000influential reference
• Inter-rater reliability for identification of REM sleep in Parkinson's disease.

  2000cited by this paper
• Effect of Lesions of the Ventrolateral Preoptic Nucleus on NREM and REM Sleep

  2000cited by this paper
• Gene expression in the brain across the sleep-waking cycle.

  2000cited by this paper
• Reduced Number of Hypocretin Clinical Study Neurons in Human Narcolepsy

  2000cited by this paper
• GABAA receptor subunit gamma2 and delta subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts.

  1999cited by this paper
• Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.

  1999cited by this paper
• Incidence and remission of insomnia among elderly adults: an epidemiologic study of 6,800 persons over three years.

  1999cited by this paper
• The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene.

  1999cited by this paper
• Sleep Homeostasis and Models of Sleep Regulation

  1999cited by this paper
• Molecular and Functional Diversity of the Expanding GABA‐A Receptor Gene Family

  1999cited by this paper
• Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

  1999cited by this paper
• Benzodiazepine actions mediated by specific γ-aminobutyric acidA receptor subtypes

  1999cited by this paper
• GABAA receptor subunit γ2 and δ subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts

  1999cited by this paper
• Innervation of Histaminergic Tuberomammillary Neurons by GABAergic and Galaninergic Neurons in the Ventrolateral Preoptic Nucleus of the Rat

  1998cited by this paper
• From GABAA receptor diversity emerges a unified vision of GABAergic inhibition.

  1998cited by this paper
• The GABAA agonist THIP produces slow wave sleep and reduces spindling activity in NREM sleep in humans

  1997cited by this paper
• Sleep and arousal: thalamocortical mechanisms.

  1997cited by this paper
• The GABAA agonist THIP (gaboxadol) increases non‐REM sleep and enhances delta activity in the rat

  1996cited by this paper
• Immunocytochemical localization of the alpha 1 and beta 2/3 subunits of the GABAA receptor in relation to specific GABAergic synapses in the dentate gyrus.

  1995cited by this paper
• Network modulation of a slow intrinsic oscillation of cat thalamocortical neurons implicated in sleep delta waves: cortically induced synchronization and brainstem cholinergic suppression

  1991cited by this paper
• Two sexually dimorphic cell groups in the human brain

  1989cited by this paper
• Sleep suppression following kainic acid-induced lesions of the basal forebrain.

  1986cited by this paper
• Sleep Suppression after Basal Forebrain Lesions in the Cat

  1968cited by this paper

• Sleep-promoting effects and potential mechanisms of Apocynum venetum leaf extract (VENETRON®): Effects of acute and chronic treatment on the sleep-wake profiles in mice.

  2025cites this paper
• Fly into Tranquility: GABA's role in Drosophila Sleep.

  2024cites this paper
• Production and quality evaluation of a novel γ-aminobutyric acid-enriched yogurt

  2024cites this paper
• Protein phosphatase 2A inhibitors: a possible pharmacotherapy for benzodiazepine dependence.

  2024cites this paper
• Key actors in neuropathophysiology: The role of γδ T cells

  2024cites this paper
• Increased Risk of Sudden Sensorineural Hearing Loss in Patients Receiving Sedative-Hypnotics: A Propensity Score Weighting Cohort Study

  2024cites this paper
• Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs in Drosophila

  2023cites this paper
• Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs in Drosophila

  2023cites this paper
• Glymphatic dysfunction coincides with lower GABA levels and sleep disturbances in succinic semialdehyde dehydrogenase deficiency

  2023cites this paper
• Establishment and validation of a clinical severity scoring system for succinic semialdehyde dehydrogenase deficiency

  2023cites this paper
• Voltage-clamp evidence of GABA_A receptor subunit-specific effects: pharmacodynamic fingerprint of chlornordiazepam, the major active metabolite of mexazolam, as compared to alprazolam, bromazepam, and zolpidem

  2022influential citation
• The Case for Clinical Trials with Novel GABAergic Drugs in Diabetes Mellitus and Obesity

  2022cites this paper
• A Combination of Rosa Multiflora and Zizyphus Jujuba Enhance Sleep Quality in Anesthesia-Induced Mice

  2022cites this paper
• Anthocyanin-rich fruits and mental health outcomes in an Italian cohort

  2022cites this paper
• Evaluation of Bioactive Compounds and Antioxidative Activity of Fermented Green Tea Produced via One- and Two-Step Fermentation

  2022cites this paper
• The Effects of Dietary Nutrition on Sleep and Sleep Disorders

  2020cites this paper
• The voltage-gated potassium channel Shaker promotes sleep via thermosensitive GABA transmission

  2020cites this paper
• Depressant effect of geraniol on the central nervous system of rats: Behavior and ECoG power spectra

  2018cites this paper
• The Influence of Regional Distribution and Pharmacologic Specificity of GABAAR Subtype Expression on Anesthesia and Emergence

  2017cites this paper
• Relationship of nocturnal concentrations of melatonin, gamma-aminobutyric acid and total antioxidants in peripheral blood with insomnia after stroke: study protocol for a prospective non-randomized controlled trial

  2017cites this paper
• The Evolution and Function of Sleep

  2017cites this paper
• En busqueda del hipnótico ideal: tratamiento farmacológico del insomnio

  2017cites this paper
• Biotransformation of monosodium glutamate to gamma-aminobutyric acid by isolated strain Lactobacillus brevis L-32 for potentiation of pentobarbital-induced sleep in mice

  2017cites this paper
• Chapter 42 – Clinical Pharmacology of Other Drugs Used as Hypnotics

  2017cites this paper
• Conversion factors for assessment of driving impairment after exposure to multiple benzodiazepines/z-hypnotics or opioids.

  2017cites this paper
• Hypocretins and Arousal.

  2016cites this paper
• Hypocretins, Neural Systems, Physiology, and Psychiatric Disorders

  2016cites this paper
• Targeting the orexinergic system: Mainly but not only for sleep-wakefulness therapies

  2015cites this paper
• Non-Benzodiazepine Receptor Agonists for Insomnia.

  2015cites this paper
• Anxiolytic-like effects of restraint during the dark cycle in adolescent mice.

  2015cites this paper
• Top-down and bottom-up control of drug-induced sleep and anaesthesia

  2015cites this paper
• Factors Associated With Drug Non-Adherence After Discharge Among Patients With Mood Disorders Hospitalized in Shahid Beheshti Hospital in Kerman: A Prospective Study

  2015cites this paper
• Context odor presentation during sleep enhances memory in honeybees.

  2015cites this paper
• Combination Treatment of Tamoxifen with Risperidone in Breast Cancer

  2014cites this paper
• The Drosophila neuropeptides PDF and sNPF have opposing electrophysiological and molecular effects on central neurons.

  2014cites this paper
• Zolpidem Reduces Hippocampal Neuronal Activity in Freely Behaving Mice: A Large Scale Calcium Imaging Study with Miniaturized Fluorescence Microscope

  2014cites this paper
• Time- and Behavioral State-Dependent Changes in Posterior Hypothalamic GABAA Receptors Contribute to the Regulation of Sleep

  2014cites this paper
• Effect of sedative-hypnotics, anesthetics and analgesics on sleep architecture in obstructive sleep apnea

  2014cites this paper
• The behavioral pharmacology of zolpidem: evidence for the functional significance of α1-containing GABAA receptors

  2014cites this paper
• Pharmacological evaluation of sedative and hypnotic effects of schizandrin through the modification of pentobarbital-induced sleep behaviors in mice.

  2014cites this paper
• Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABAergic system.

  2014cites this paper
• Bases bioquímicas implicadas en la regulación del sueño

  2013cites this paper
• Bases bioquímicas implicadas en la regulación del sueño

  2013cites this paper
• The glycolytic metabolite methylglyoxal induces changes in vigilance by generating low-amplitude non-REM sleep

  2013cites this paper
• Extrasynaptic GABAA receptors in rat pontine reticular formation increase wakefulness.

  2013cites this paper
• Avaliação dos efeitos de fármacos benzodiazepínicos sobre o catabolismo de nucleotídeos, nucleosídeos e acetilcolina em encéfalo de zebrafish adulto: (Danio rerio)

  2013cites this paper
• Concentrations of zolpidem and zopiclone in venous blood samples from impaired drivers compared with femoral blood from forensic autopsies.

  2012cites this paper
• α4βδ GABAA receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)

  2012cites this paper
• Cellular bases of focal and generalized epilepsies.

  2012cites this paper
• Complex Behaviors Related to Zolpidem: An Analysis of Published Clinical Cases from Taiwan

  2012cites this paper
• Enhanced slow wave sleep and improved sleep maintenance after gaboxadol administration during seven nights of exposure to a traffic noise model of transient insomnia

  2012cites this paper
• Endogenous GABA Levels in the Pontine Reticular Formation Are Greater during Wakefulness than during Rapid Eye Movement Sleep

  2011cites this paper
• Risk of Fractures Requiring Hospitalization After an Initial Prescription for Zolpidem, Alprazolam, Lorazepam, or Diazepam in Older Adults

  2011cites this paper
• Prospective relationships of ADHD symptoms with developing substance use in a population-derived sample

  2011cites this paper
• Recognition and subsequent treatment of patients with sub-threshold symptoms of depression in primary care.

  2011cites this paper
• GABA and Sleep: Molecular, Functional and Clinical Aspects

  2011cites this paper
• Neurosteroid Influences on Sensitivity to Ethanol

  2011cites this paper
• Testing the silence of mutations: Transcriptomic and behavioral studies of GABA(A) receptor α1 and α2 subunit knock-in mice.

  2011cites this paper
• Central nervous system sites of the sleep promoting effects of eszopiclone in rats.

  2011cites this paper
• L-ornithine attenuates corticotropin-releasing factor-induced stress responses acting at GABAA receptors in neonatal chicks.

  2011cites this paper
• Profound Desensitization by Ambient GABA Limits Activation of δ-Containing GABAA Receptors during Spillover

  2011cites this paper
• Adverse reactions to zolpidem: case reports and a review of the literature.

  2010cites this paper
• Insomnia risks and costs: health, safety, and quality of life.

  2010cites this paper
• Benzodiazepine receptor agonists cause drug-specific and state-specific alterations in EEG power and acetylcholine release in rat pontine reticular formation.

  2010cites this paper
• Limiting Activity at β1-Subunit-Containing GABAA Receptor Subtypes Reduces Ataxia

  2010cites this paper
• A population‐based association study of candidate genes for depression and sleep disturbance

  2010cites this paper
• Thermodynamic laws apply to brain function.

  2010cites this paper
• Searching for perfect sleep: the continuing evolution of GABAA receptor modulators as hypnotics

  2010cites this paper
• Adult zebrafish as a model organism for behavioural genetics

  2010cites this paper
• Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure.

  2010cites this paper
• Development of subtype-selective GABAA receptor compounds for the treatment of anxiety, sleep disorders and epilepsy

  2010cites this paper
• Zolpidem modulation of phasic and tonic GABA currents in the rat dorsal motor nucleus of the vagus.

  2010cites this paper
• Pharmacological modulation of brain levels of glutamate and GABA in rats exposed to total sleep deprivation

  2010cites this paper
• Tonic GABAA receptor-mediated inhibition in the rat dorsal motor nucleus of the vagus.

  2010influential citation
• Combining Medications to Achieve Remission

  2009cites this paper
• The regulatory properties of α5 subunit-containing γ-aminobutyric acid subtype A receptors in learning and synaptic plasticity.

  2009cites this paper
• The possible role of human milk nucleotides as sleep inducers

  2009cites this paper
• Slow intracellular accumulation of GABA(A) receptor delta subunit is modulated by brain-derived neurotrophic factor.

  2009cites this paper
• Rodent models of insomnia: a review of experimental procedures that induce sleep disturbances.

  2009influential citation
• The role of eszopiclone in the treatment of insomnia

  2009cites this paper
• Zolpidem-induced sleepwalking, sleep related eating disorder, and sleep-driving: fluorine-18-flourodeoxyglucose positron emission tomography analysis, and a literature review of other unexpected clinical effects of zolpidem.

  2009cites this paper
• Conservation of sleep: insights from non-mammalian model systems.

  2008cites this paper
• Retinopathy associated with ivermectin toxicosis in two dogs.

  2008cites this paper
• Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 394 Hormones , Mood and Cognition

  2008influential citation
• l-Serine induces sedative and hypnotic effects acting at GABA(A) receptors in neonatal chicks.

  2008cites this paper
• Hormones, Mood and Cognition

  2008influential citation
• Retinopathy associated with ivermectin toxicosis in two dogs

  year unknowncites this paper
• Retinopathy associated with ivermectin toxicosis in two dogs

  year unknowncites this paper
• Retinopathy associated with ivermectin toxicosis in two dogs

  year unknowncites this paper
• Retinopathy associated with ivermectin toxicosis in two dogs

  year unknowncites this paper
• Retinopathy associated with ivermectin toxicosis in two dogs

  year unknowncites this paper
• Retinopathy associated with ivermectin toxicosis in two dogs

  year unknowncites this paper
• Retinopathy associated with ivermectin toxicosis in two dogs

  year unknowncites this paper
• Retinopathy associated with ivermectin toxicosis in two dogs

  year unknowncites this paper
• Retinopathy associated with ivermectin toxicosis in two dogs

  year unknowncites this paper
• Retinopathy associated with ivermectin toxicosis in two dogs

  year unknowncites this paper
• Retinopathy associated with ivermectin toxicosis in two dogs

  year unknowncites this paper
• Retinopathy associated with ivermectin toxicosis in two dogs

  year unknowncites this paper