EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion

Metalloproteinase-mediated cleavage of EphA2 induces breast tumor cells to shift from collective invasion to single-cell invasion.

• Publication year

  2013

• Venue

  Journal of Cell Biology

• Publication date

  2013-04-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.201205176PMID 23629968PMCID 3639392
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cancer invasion and resistance: interconnected processes of disease progression and therapy failure.

  2012cited by this paper
• Clinical relevance of Ephs and ephrins in cancer: lessons from breast, colorectal, and lung cancer profiling.

  2012cited by this paper
• EphA receptor signaling--complexity and emerging themes.

  2012cited by this paper
• MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis.

  2012cited by this paper
• Concepts and consequences of Eph receptor clustering.

  2012cited by this paper
• Eph/Ephrin Profiling in Human Breast Cancer Reveals Significant Associations between Expression Level and Clinical Outcome

  2011cited by this paper
• Cell-matrix adhesions in 3D.

  2011cited by this paper
• Extracellular matrix determinants of proteolytic and non-proteolytic cell migration.

  2011cited by this paper
• Eph-dependent cell-cell adhesion and segregation in development and cancer

  2011cited by this paper
• EphA2 Induces Metastatic Growth Regulating Amoeboid Motility and Clonogenic Potential in Prostate Carcinoma Cells

  2011cited by this paper
• Cancer esearch cular and Cellular Pathobiology oblast Growth Factor Receptor 4 Regulates Tumor sion by Coupling Fibroblast Growth Factor Signaling to R acellular Matrix Degradation

  2010cited by this paper
• Mechanisms of Motility in Metastasizing Cells

  2010cited by this paper
• EphA2 Mutation in Lung Squamous Cell Carcinoma Promotes Increased Cell Survival, Cell Invasion, Focal Adhesions, and Mammalian Target of Rapamycin Activation*

  2010cited by this paper
• Architecture of Eph receptor clusters

  2010cited by this paper
• The plasticity of cytoskeletal dynamics underlying neoplastic cell migration.

  2010cited by this paper
• Dynamic interplay between the collagen scaffold and tumor evolution.

  2010cited by this paper
• Intravital imaging illuminates transforming growth factor beta signaling switches during metastasis.

  2010cited by this paper
• Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism

  2010cited by this paper
• An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly

  2010cited by this paper
• FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase–FGFR4 complex

  2010cited by this paper
• Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells

  2010cited by this paper
• Localised and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility

  2009cited by this paper
• EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts.

  2009cited by this paper
• EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt.

  2009cited by this paper
• Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1

  2009cited by this paper
• EphA2 reexpression prompts invasion of melanoma cells shifting from mesenchymal to amoeboid-like motility style.

  2009cited by this paper
• Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited

  2009cited by this paper
• MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing

  2009cited by this paper
• EphA2 as a promoter of melanoma tumorigenicity

  2009cited by this paper
• Eph-ephrin bidirectional signaling in physiology and disease.

  2008cited by this paper
• Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling.

  2008cited by this paper
• Molecular dissection of the structural machinery underlying the tissue-invasive activity of membrane type-1 matrix metalloproteinase.

  2008cited by this paper
• MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1.

  2008cited by this paper
• The EphA2 Receptor and EphrinA1 Ligand in Solid Tumors: Function and Therapeutic Targeting

  2008cited by this paper
• Microenvironmental Regulation of Membrane Type 1 Matrix Metalloproteinase Activity in Ovarian Carcinoma Cells via Collagen-induced EGR1 Expression*

  2007cited by this paper
• Src-dependent Phosphorylation of Membrane Type I Matrix Metalloproteinase on Cytoplasmic Tyrosine 573

  2007cited by this paper
• Cell-cell signaling via Eph receptors and ephrins.

  2007cited by this paper
• MT1‐MMP: A potent modifier of pericellular microenvironment

  2006cited by this paper
• A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.

  2006influential reference
• A conditional feedback loop regulates Ras activity through EphA2.

  2005cited by this paper
• Developmental cell biology: Eph receptor signalling casts a wide net on cell behaviour

  2005cited by this paper
• Expression pattern of four membrane‐type matrix metalloproteinases in the normal and diseased mouse mammary gland

  2005cited by this paper
• Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans.

  2005cited by this paper
• EphA2 as a Novel Molecular Marker and Target in Glioblastoma Multiforme

  2005cited by this paper
• An MT1-MMP-PDGF receptor-beta axis regulates mural cell investment of the microvasculature.

  2005cited by this paper
• ADAMs: key components in EGFR signalling and development

  2005cited by this paper
• Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix.

  2003cited by this paper
• The Journal of Cell Biology

  2002cited by this paper
• Oligomerization through Hemopexin and Cytoplasmic Domains Regulates the Activity and Turnover of Membrane-type 1 Matrix Metalloproteinase*

  2002cited by this paper
• E-cadherin regulates the function of the EphA2 receptor tyrosine kinase.

  1999cited by this paper
• Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas.

  1995cited by this paper
• Analysing collisions between fibroblasts and fibrosarcoma cells: fibrosarcoma cells show an active invasionary response.

  1986cited by this paper

• Matrix Metalloproteinase 14 in Corneal Neovascularization.

  2026cites this paper
• A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer.

  2025cites this paper
• Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role

  2025cites this paper
• Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role.

  2025cites this paper
• Proteomic Analysis of PTEN-Deficient Cells Reveals Src-Mediated Upregulation of EphA2 and Therapeutic Potential of Dual Inhibition

  2025cites this paper
• Serum levels of EphA2 are elevated in knee osteoarthritis and associated with disease severity

  2025cites this paper
• Polyploidy of MDA-MB-231 cells drives increased extravasation with enhanced cell-matrix adhesion

  2025cites this paper
• Involvement of β-glucan receptors on the antitumor activity of β-glucans

  2024cites this paper
• Missense mutations of the ephrin receptor EPHA1 associated with Alzheimer’s disease disrupt receptor signaling functions

  2024cites this paper
• Extracellular proteolysis in cancer: Proteases, substrates, and mechanisms in tumor progression and metastasis

  2024cites this paper
• Recent advances of the Ephrin and Eph family in cardiovascular development and pathologies

  2024cites this paper
• EphA2 in Cancer: Molecular Complexity and Therapeutic Opportunities

  2024cites this paper
• EphA2 Proteolytic Fragment as a Sensitive Diagnostic Biomarker for Very Early-stage Pancreatic Ductal Carcinoma

  2023cites this paper
• A general approach for selection of epitope-directed binders to proteins

  2023cites this paper
• Eph receptors and ephrins in cancer progression

  2023cites this paper
• Opposite and dynamic regulation of the interferon response in metastatic and non-metastatic breast cancer

  2023influential citation
• Characterizing the function-related specific assembly pattern of matrix metalloproteinase-14 by dSTORM imaging.

  2023cites this paper
• Coordination of two kinesin superfamily motor proteins, KIF3A and KIF13A, is essential for pericellular matrix degradation by membrane-type 1 matrix metalloproteinase (MT1-MMP) in cancer cells

  2022cites this paper
• RSK-Mediated Non-canonical Activation of EphA2 by Tamoxifen.

  2022cites this paper
• Direct Identification of Proteolytic Cleavages on Living Cells Using a Glycan-Tethered Peptide Ligase

  2022cites this paper
• Proteolytic cleavage of membrane proteins by membrane type‐1 MMP regulates cancer malignant progression

  2022cites this paper
• Proteolytic modulation of tumor microenvironment signals during cancer progression

  2022cites this paper
• Pparγ1 Facilitates ErbB2-Mammary Adenocarcinoma in Mice

  2021cites this paper
• Emerging roles of MT‐MMPs in embryonic development

  2021cites this paper
• Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility

  2021cites this paper
• Advances in the study of cancer metastasis and calcium signaling as potential therapeutic targets

  2021cites this paper
• Probe the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility

  2021cites this paper
• Oncogenic Functions and Therapeutic Targeting of EphA2 in Cancer

  2021cites this paper
• Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling duality

  2021cites this paper
• Coordination of KIF3A and KIF13A regulates leading edge localization of MT1-MMP to promote cancer cell invasion

  2021cites this paper
• Adaptive RSK‐EphA2‐GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer

  2020influential citation
• High MMP14 expression is predictive of poor prognosis in resectable hepatocellular carcinoma.

  2020cites this paper
• A new scfv-based recombinant immunotoxin against EPHA2-overexpressing breast cancer cells; High in vitro anti-cancer potency.

  2020cites this paper
• PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential

  2020cites this paper
• Metalloproteinases and their roles in human cancer

  2020cites this paper
• Eph receptor signalling: from catalytic to non-catalytic functions

  2019cites this paper
• The Expanding Role of MT1-MMP in Cancer Progression

  2019cites this paper
• MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues

  2019cites this paper
• Association of BCSC-1 and MMP-14 with human breast cancer

  2018cites this paper
• Spatially modulated ephrinA1:EphA2 signaling increases local contractility and global focal adhesion dynamics to promote cell motility

  2018cites this paper
• PROX1 is a transcriptional regulator of MMP14

  2018cites this paper
• Gamma-secretase-dependent signaling of receptor tyrosine kinases

  2018cites this paper
• Potential roles of metalloproteinases of endometrium‐derived exosomes in embryo‐maternal crosstalk during implantation

  2018cites this paper
• Tyrosine kinase activity of EphA2 promotes its S897 phosphorylation and glioblastoma cell proliferation.

  2018cites this paper
• Identification of Proteolytic Cleavage Sites of EphA2 by Membrane Type 1 Matrix Metalloproteinase on the Surface of Cancer Cells.

  2018cites this paper
• Effects of Localized EphB2 Stimulation on Dendritic Filopodia of Hippocampal Neurons

  2018cites this paper
• The EphA2 receptor is activated through induction of distinct, ligand-dependent oligomeric structures

  2018cites this paper
• Making Connections: Guidance Cues and Receptors at Nonneural Cell-Cell Junctions.

  2018cites this paper
• Irreversible modifications of receptor tyrosine kinases

  2018cites this paper
• Specific detection of soluble EphA2 fragments in blood as a new biomarker for pancreatic cancer

  2017cites this paper
• Paradoxes of the EphB1 receptor in malignant brain tumors

  2017cites this paper
• Membrane-type matrix metalloproteases as diverse effectors of cancer progression.

  2017cites this paper
• Emerging and Diverse Functions of the EphA2 Noncanonical Pathway in Cancer Progression.

  2017cites this paper
• Orphan G protein-coupled receptor GPRC5A modulates integrin β1-mediated epithelial cell adhesion

  2017cites this paper
• When chemical proteomics meets medicinal chemistry: Guided drug discovery towards EPHA2 inhibitors

  2017cites this paper
• EphA2 N-TERMINUS FRAGMENT ANTIBODY

  2017cites this paper
• Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion

  2017cites this paper
• an overview of cancer-associated membrane proteins

  2017cites this paper
• Integrated functions of membrane‐type 1 matrix metalloproteinase in regulating cancer malignancy: Beyond a proteinase

  2017cites this paper
• Molecular mechanisms of EphB-ephrinB endocytosis in neural cells

  2016cites this paper
• Cell polarity signaling in the plasticity of cancer cell invasiveness

  2016cites this paper
• Protein kinase A can block EphA2 receptor–mediated cell repulsion by increasing EphA2 S897 phosphorylation

  2016cites this paper
• Downregulation of human intercellular adhesion molecule-1 attenuates the metastatic ability in human breast cancer cell lines.

  2016cites this paper
• Cross-talk between the Tissue Factor/coagulation factor VIIa complex and the tyrosine kinase receptor EphA2 in cancer

  2016cites this paper
• Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells

  2016cites this paper
• Selecting Targets for Tumor Imaging: An Overview of Cancer-Associated Membrane Proteins

  2016cites this paper
• Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin

  2016cites this paper
• Novel anti-EPHA2 antibody, DS-8895a for cancer treatment

  2016cites this paper
• Proactive for invasion: Reuse of matrix metalloproteinase for structural memory

  2016cites this paper
• Immunohistochemical demonstration of EphA2 processing by MT1-MMP in invasive cutaneous squamous cell carcinoma

  2016influential citation
• Proteolytic regulation of the EphB4-Ephrin-B2 signalling axis in prostate cancer

  2016cites this paper
• Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein.

  2015cites this paper
• Eph receptors and ephrins: therapeutic opportunities.

  2015cites this paper
• Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1075 Studies on Tissue Factor with Focus on Cell Signaling and Cancer

  2015cites this paper
• MMP-14 in skeletal muscle repair

  2015cites this paper
• MMP14 Cleavage of VEGFR1 in the Cornea Leads to a VEGF-Trap Antiangiogenic Effect.

  2015cites this paper
• Targeting tumor invasion: the roles of MDA-9/Syntenin

  2015cites this paper
• SrGAP2-Dependent Integration of Membrane Geometry and Slit-Robo-Repulsive Cues Regulates Fibroblast Contact Inhibition of Locomotion.

  2015cites this paper
• Collective cell migration: guidance principles and hierarchies.

  2015cites this paper
• Studying Signal Transduction Networks with a Probabilistic Boolean Network Approach

  2015cites this paper
• Roles of novel biomarkers in progression of cutaneous squamous cell carcinoma

  2015cites this paper
• Cytotoxic activity of Indian, Indonesian and UK plant extracts on breast cancer cells

  2015cites this paper
• MMPs in Biology and Medicine

  2015cites this paper
• An investigation into the role of Rab-Coupling Protein and EphA2 during cancer cell migration

  2015influential citation
• The Eph Receptor Family

  2015cites this paper
• Calcium Signaling and Ca 2+ /Calmodulin-Dependent Kinase II Activity in Epithelial To Mesenchymal Transition

  2015cites this paper
• Screening for tumor suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRas in promoting lung adenocarcinoma

  2015cites this paper
• MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma.

  2015cites this paper
• Implication de réseaux de récepteurs membranaires dans la signalisation du NGF et de son précurseur dans les cellules cancéreuses de sein

  2014cites this paper
• Procédé d'examen du cancer et kit d'examen

  2014cites this paper
• EphA receptors regulate prostate cancer cell dissemination through Vav2–RhoA mediated cell–cell repulsion

  2014cites this paper
• Eph- and ephrin-dependent mechanisms in tumor and stem cell dynamics

  2014influential citation
• Eph receptor and ephrin function in breast, gut, and skin epithelia

  2014influential citation
• The Eph Tyrosine Kinase Receptors EphB2 and EphA2 Are Novel Proteolytic Substrates of Tissue Factor/Coagulation Factor VIIa*

  2014cites this paper
• EphA4 receptor shedding regulates spinal motor axon guidance.

  2014cites this paper
• The role of proteases in regulating Eph/ephrin signaling

  2014influential citation
• Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton

  2014cites this paper
• EphA2 cleavage helps tumor cells go it alone

  2013cites this paper
• EphA2 bears plasticity to tumor invasion

  2013cites this paper
• World Journal of Gastrointestinal Oncology

  year unknowncites this paper